Shedding light on microglial dysregulation in Alzheimer’s disease: exploring molecular mechanisms and therapeutic avenues DOI
Vinay Bhardwaj, Sneha Kumari,

Rishika Dhapola

et al.

Inflammopharmacology, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 28, 2024

Language: Английский

Exploring Retinal Neurodegeneration in Alzheimer’s Disease: A Molecular and Cellular Perspective DOI

Rishika Dhapola,

Prajjwal Sharma,

Sneha Kumari

et al.

Neurotoxicity Research, Journal Year: 2025, Volume and Issue: 43(2)

Published: April 1, 2025

Language: Английский

Citations

0
Unraveling the Immune Puzzle: Role of Immunomodulation in Alzheimer’s Disease DOI

Ashvin,

Rishika Dhapola,

Sneha Kumari

et al.

Journal of Neuroimmune Pharmacology, Journal Year: 2025, Volume and Issue: 20(1)

Published: April 29, 2025

Language: Английский

Citations

0
Design, Synthesis, and Biological Evaluation of Imidazolylacetophenone Oxime Derivatives as Novel Brain-Penetrant Agents for Alzheimer’s Disease Treatment DOI

Zhao-Yuan Bian,

Peng‐Xiao Li,

Xu-Yao Feng

et al.

European Journal of Medicinal Chemistry, Journal Year: 2024, Volume and Issue: 278, P. 116794 - 116794

Published: Aug. 30, 2024

Language: Английский

Citations

3
Association Between the Gut Microbiota and Alzheimer’s Disease: An Update on Signaling Pathways and Translational Therapeutics DOI
Rahul Kulkarni, Sneha Kumari,

Rishika Dhapola

et al.

Molecular Neurobiology, Journal Year: 2024, Volume and Issue: 62(4), P. 4499 - 4519

Published: Oct. 26, 2024

Language: Английский

Citations

3
Decoding Paradoxical Links of Cytokine Markers in Cognition: Cross talk between Physiology, Inflammaging, and Alzheimer’s Disease- Related Cognitive Decline DOI
Hiba Khan,

Talib Naseem,

Pooja Kaushik

et al.

Ageing Research Reviews, Journal Year: 2024, Volume and Issue: 101, P. 102535 - 102535

Published: Oct. 6, 2024

Language: Английский

Citations

2
From Plaques to Pathways in Alzheimer’s Disease: The Mitochondrial-Neurovascular-Metabolic Hypothesis DOI Open Access
Sarah Kazemeini, Ahmed Nadeem-Tariq, Ryan M. Shih

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(21), P. 11720 - 11720

Published: Oct. 31, 2024

Alzheimer's disease (AD) presents a public health challenge due to its progressive neurodegeneration, cognitive decline, and memory loss. The amyloid cascade hypothesis, which postulates that the accumulation of amyloid-beta (Aβ) peptides initiates leading AD, has dominated research therapeutic strategies. failure recent Aβ-targeted therapies yield conclusive benefits necessitates further exploration AD pathology. This review proposes Mitochondrial-Neurovascular-Metabolic (MNM) integrates mitochondrial dysfunction, impaired neurovascular regulation, systemic metabolic disturbances as interrelated contributors pathogenesis. Mitochondrial hallmark leads oxidative stress bioenergetic failure. Concurrently, breakdown blood-brain barrier (BBB) cerebral blood flow, characterize dysregulation, accelerate neurodegeneration. Metabolic such glucose hypometabolism insulin resistance impair neuronal function survival. hypothesis highlights interconnectedness these pathways suggests strategies targeting health, integrity, regulation may offer more effective interventions. MNM addresses multifaceted aspects providing comprehensive framework for understanding progression developing novel approaches. approach paves way innovative could significantly improve outcomes millions affected worldwide.

Language: Английский

Citations

2
Shedding light on microglial dysregulation in Alzheimer’s disease: exploring molecular mechanisms and therapeutic avenues DOI
Vinay Bhardwaj, Sneha Kumari,

Rishika Dhapola

et al.

Inflammopharmacology, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 28, 2024

Language: Английский

Citations

2