Sleep disorders increase the risk of dementia, Alzheimer’s disease, and cognitive decline: a meta-analysis

GeroScience, Journal Year: 2025, Volume and Issue: unknown

Published: April 11, 2025

Abstract Sleep disorders, particularly insomnia and obstructive sleep apnea, are increasingly implicated as significant contributors to cognitive decline, dementia, neurodegenerative diseases such Alzheimer’s disease (AD) vascular impairment dementia (VCID). However, the extent specificity of these associations remain uncertain. This meta-analysis evaluates impact common disorders on risk developing decline. A comprehensive search literature was conducted identify prospective cohort studies assessing risk. Studies reporting estimates for AD, or decline associated with insomnia, other (e.g., restless legs syndrome, circadian rhythm excessive daytime sleepiness) were included. Meta-analyses performed using a random-effects model calculate pooled hazard ratios (HRs) 95% confidence intervals (CIs). Thirty-nine included, subgroup analyses showing between all-cause apnea (HR 1.33, CI 1.09–1.61), 1.36, 1.19–1.55), 1.24–1.43). Obstructive increased AD 1.45, 1.24–1.69), though its association did not reach statistical significance 1.35, 0.99–1.84). Insomnia significantly both 1.59, 1.01–2.51) 1.49, 1.27–1.74). highlights critical role in risk, emphasizing need early detection management disturbances. Targeted interventions could play pivotal reducing among high-risk populations.

Language: Английский

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OLFACTORY INTERVENTIONS FOR SLEEP ENHANCEMENT: A REVIEW

Universal Journal of Pharmaceutical Research, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 15, 2025

Sleep is essential for cognitive function, emotional balance, and overall well-being. Disruptions like insomnia or poor sleep quality can have negative consequences. Various methods, including bedtime perfumes, been studied to improve sleep. This review examines the scientific basis of scent-based enhancement, focusing on olfactory system effects specific aromatic compounds The plays a crucial role in how scents influence Odor molecules bind receptors nasal cavity, sending signals bulb, which processes these relays them limbic system. connection allows evoke responses impact Historically, scent therapy has used across cultures. effectiveness perfumes depends their delivery methods. Diffusers, sprays roll-on oils are common ways disperse oils. Incorporating into comprehensive hygiene routine, consistent schedule calming environment, maximizes benefits. Future research should identify that induce sleep, explore interaction between stimuli stages investigate long-term safety efficacy perfumes. In conclusion, through power scent. Understanding pathways, historical context helps individuals make informed choices about using fragrances. Peer Review History: Received 2 October 2024; Reviewed 11 November; Accepted 20 December; Available online 15 January 2025 Academic Editor: Dr. Gehan Fawzy Abdel Raoof Kandeel, Pharmacognosy Department, National Research Centre, Dokki, 12622, Giza, Egypt, [email protected] Average marks at initial stage: 6.5/10 publication 7.0/10

Language: Английский

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Exploring the effects of combined nostalgic activities and music therapy on Alzheimer's disease outcomes

Frontiers in Psychology, Journal Year: 2025, Volume and Issue: 16

Published: Jan. 30, 2025

Objective Exploring the effects of combination nostalgic activity-based therapies, including music therapy on cognitive function, negative emotions, and sleep quality in patients with mild to moderate Alzheimer's disease. Methods A total 63 disease who were treated at Sichuan Provincial Psychiatric Center People's Hospital Province from January June 2023 selected as research subjects. They randomly divided into a study group ( n = 31) control 32) using random number table method. The received routine treatment nursing care, while intervention basis group. Mini Mental State Examination (MMSE), Montreal Cognitive Assessment Scale (MOCA), Self Rating Anxiety Depression (SAS, SDS), Pittsburgh Sleep Quality Index (PSQI) two groups compared. Results 30 cases each completed study. After 12 weeks intervention, MMSE MOCA scores both increased, was higher than P < 0.05); SAS, SDS PSQI decreased compared those before lower 0.05). Conclusion Nostalgic can improve alleviate

Language: Английский

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Decoding Multifaceted Roles of Sleep-Related Genes as Molecular Bridges in Chronic Disease Pathogenesis

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(7), P. 2872 - 2872

Published: March 21, 2025

Sleep is a fundamental process essential for all organisms. deprivation can lead to significant detrimental effects, contributing various physiological disorders and elevating the risk of several diseases. Investigating relationship between sleep human diseases offers valuable insights into molecular mechanisms governing regulation, potentially guiding development more effective treatments associated This study explored roles sleep-related genes in biological processes their associations with chronic diseases, mainly including neurological, metabolic, cardiovascular cancer. Additionally, an analysis on was also performed understand potential role tumorigenesis. review aims enhance understanding link novel therapeutic approaches targeting circadian rhythm-related

Language: Английский

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