Exposome in ischaemic heart disease: beyond traditional risk factors

European Heart Journal, Год журнала: 2024, Номер 45(6), С. 419 - 438

Опубликована: Янв. 18, 2024

Abstract Ischaemic heart disease represents the leading cause of morbidity and mortality, typically induced by detrimental effects risk factors on cardiovascular system. Although preventive interventions tackling conventional have helped to reduce incidence ischaemic disease, it remains a major death worldwide. Thus, attention is now shifting non-traditional in built, natural, social environments that collectively contribute substantially burden perpetuate residual risk. Of importance, these complex interact non-linearly unpredictable ways often enhance attributable single or collection factors. For this reason, new paradigm called ‘exposome’ has recently been introduced epidemiologists order define totality exposure The purpose review outline how emerging may occurrence with particular impact long-term different environmental pollutants, socioeconomic psychological factors, along infectious diseases such as influenza COVID-19. Moreover, potential mitigation strategies for both individuals communities will be discussed.

Язык: Английский

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Environmental Pollutants as Emerging Concerns for Cardiac Diseases: A Review on Their Impacts on Cardiac Health

Biomedicines, Год журнала: 2025, Номер 13(1), С. 241 - 241

Опубликована: Янв. 20, 2025

Comorbidities related to cardiovascular disease (CVD) and environmental pollution have emerged as serious concerns. The exposome concept underscores the cumulative impact of factors, including climate change, air pollution, chemicals like PFAS, heavy metals, on health. Chronic exposure these pollutants contributes inflammation, oxidative stress, endothelial dysfunction, further exacerbating global burden CVDs. Specifically, carbon monoxide (CO), ozone, particulate matter (PM2.5), nitrogen dioxide (NO2), sulfur (SO2), pesticides, micro- nanoplastics been implicated in morbidity mortality through various mechanisms. PM2.5 leads inflammation metabolic disruptions. Ozone CO induce stress vascular dysfunction. NO2 cardiac remodeling acute events, metals exacerbate cellular damage. Pesticides microplastics pose emerging risks linked tissue Monitoring risk assessment play a crucial role identifying vulnerable populations assessing pollutant impacts, considering factors age, gender, socioeconomic status, lifestyle disorders. This review explores disease, discussing risk-assessment methods, intervention strategies, challenges clinicians face addressing pollutant-induced diseases. It calls for stronger regulatory policies, public health interventions, green urban planning.

Язык: Английский

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Neighborhoods and Cardiovascular Health: A Scientific Statement From the American Heart Association

Circulation Cardiovascular Quality and Outcomes, Год журнала: 2023, Номер 17(1)

Опубликована: Дек. 11, 2023

The neighborhoods where individuals reside shape environmental exposures, access to resources, and opportunities. inequitable distribution of resources opportunities across perpetuates exacerbates cardiovascular health inequities. Thus, interventions that address the neighborhood environment could reduce burden disease in disenfranchised populations. objective this scientific statement is provide a roadmap illustrating how current knowledge regarding effects on can be used develop implement effective improve at population, system, community, individual levels. PubMed/Medline, CINAHL, Cochrane Library reviews, ClinicalTrials.gov were identify observational studies examining or targeting conditions relation health. summarizes have been incorporated into actions care systems, community settings, policies involve modifying environment. This presents promising findings expanded implemented more broadly identifies methodological challenges designing evaluate important neighborhood-related interventions. Last, offers recommendations for areas merit further research promote deeper understanding contributions inequities stimulate development

Язык: Английский

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Pollution from fine particulate matter and atherosclerosis: A narrative review

Environment International, Год журнала: 2023, Номер 175, С. 107923 - 107923

Опубликована: Апрель 10, 2023

According to the WHO, entire global population is exposed air pollution levels higher than recommended for health preservation. Air a complex mixture of nano- micro-sized particles and gaseous components that poses major threat public health. Among most important pollutants, causal associations have been established between particulate matter (PM), mainly < 2.5 μm, cardiovascular diseases (CVD), i.e., hypertension, coronary artery disease, ischemic stroke, congestive heart failure, arrhythmias as well total mortality. Aim this narrative review describe critically discuss proatherogenic effects PM2.5 attributed many direct or indirect comprising endothelial dysfunction, chronic low-grade inflammatory state, increased production reactive oxygen species, mitochondrial dysfunction activation metalloproteases, all leading unstable arterial plaques. Higher concentrations pollutants are associated with presence vulnerable plaques plaque ruptures witnessing instability. often disregarded CVD risk factor, in spite fact it one main modifiable factors relevant prevention management CVD. Thus, not only structural actions should be taken order mitigate emissions, but professionals also take care counsel patients on risks pollution.

Язык: Английский

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Long-term ambient air pollution and coronary atherosclerosis: Results from the Swedish SCAPIS study

Atherosclerosis, Год журнала: 2024, Номер 397, С. 117576 - 117576

Опубликована: Май 8, 2024

Язык: Английский

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Association Between Short-Term Exposure to Ambient PM2.5 and Its Components with Hospital Admissions for Patients with Coronary Heart Disease and Comorbid Diabetes Mellitus in Beijing, China.

Environmental Research, Год журнала: 2025, Номер unknown, С. 120729 - 120729

Опубликована: Янв. 1, 2025

Язык: Английский

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Self-powered exhaust gas purification by negative ions and photoelectric catalysis based on triboelectric nanogenerator

Nano Energy, Год журнала: 2023, Номер 115, С. 108677 - 108677

Опубликована: Июль 6, 2023

Язык: Английский

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Environmental challenges facing athletes, stakeholders and spectators at Paris 2024 Olympic and Paralympic Games: an evidence-based review of mitigation strategies and recommendations

British Journal of Sports Medicine, Год журнала: 2024, Номер 58(15), С. 870 - 881

Опубликована: Июль 2, 2024

The upcoming Paris 2024 Olympic and Paralympic Games could face environmental challenges related to heat, air quality water quality. These will pose potential threats athletes impact thousands of stakeholders millions spectators. Recognising the multifaceted nature these challenges, a range strategies be essential for mitigating adverse effects on participants, spectators alike. From personalised interventions attendees comprehensive measures implemented by organisers, holistic approach is crucial address possible interplay factors during event. This evidence-based review highlights various anticipated at 2024, offering applicable athletes, Additionally, it provides recommendations Local Organising Committees International Committee that may future Games. In summary, offers solutions consideration responsible affected 2024.

Язык: Английский

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Short-term air pollution exposure and mechanisms of plaque instability in acute coronary syndromes: An optical coherence tomography study

Atherosclerosis, Год журнала: 2023, Номер 390, С. 117393 - 117393

Опубликована: Ноя. 24, 2023

Background and aimsAir pollution is emerging as an important risk factor for acute coronary syndrome (ACS). In this study we investigated the association between short-term air exposure mechanisms of plaque instability evaluated by optical coherence tomography (OCT) imaging in ACS patients.MethodsPatients with undergoing OCT were retrospectively selected. Mechanism culprit lesion was classified rupture (PR) or intact fibrous cap (IFC) OCT. Based on each case's home address, mean daily exposures to several pollutants, including particulate matter 2.5 (PM2.5), same day immediate days (up 6 days) prior index collected.Results139 patients included [69 (49.6 %) had PR 70 (50.4 IFC]. Patients PR, compared those IFC, higher PM2.5 levels ACS, without differences before ACS. At multivariate analysis, only independent predictor [OR = 1.912 per SD (8.6 μg/m3), CI95 % (1.087–3.364), p 0.025]. presented a steady increase preceding occurrence peak (p trend 0.042)ConclusionsThis demonstrates first time that exposure, associated increased pathobiological mechanism instability.

Язык: Английский

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Spatio-temporal correlation between admissions for ruptured abdominal aortic aneurysms and levels of atmospheric pollution in Italy

Current Problems in Cardiology, Год журнала: 2023, Номер 49(2), С. 102249 - 102249

Опубликована: Ноя. 29, 2023

The aim of our study was to determine a correlation between rates and number patients admitted with ruptured abdominal aortic aneurysms (rAAA) in Italian regions different levels atmospheric pollution. We analyzed possible the rate (ruptured versus not ruptured) rAAA eight Number were statistically correlated air pollution low temperature (RR = 1.90, 95% CI: 1.42, 2.1.0) (p<0.01). Even if temperatures amplified admissions for PMs exposure, also during Summer Spring there sudden increases periods higher high had comparison level However, no difference very Mean age, sex distribution, exposure established risk factors similar population regions. findings this highlight potential reduce AAA related mortality burden by addressing negative effects possibility dose-dependent effect on cardiovascular system opens research initiatives discussions about when how modulate interventions pollutants..

Язык: Английский

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