Daratumumab for autoimmune diseases: a systematic review

RMD Open, Год журнала: 2023, Номер 9(4), С. e003604 - e003604

Опубликована: Дек. 1, 2023

Refractory autoimmune diseases remain a significant challenge in clinical practice and new therapeutic options are needed. This systematic review evaluates the existing reported data on CD38-targeting antibody daratumumab as approach autoantibody-mediated diseases.A protocolised literature according to Preferred Reporting Items for Systematic Reviews Meta-Analyses guidelines was performed. Two databases (Medline Embase) were searched suitable studies. Usage of non-oncological or non-transplantation associated with pathophysiology analysed including patient characteristics, regimen, adverse events outcome.38 publications reporting course 83 patients met inclusion criteria. Daratumumab usage therapy-refractory cases (median 5 different previous therapies) 24 diseases. The median number applications 4, mainly via intravenous (87%). Concomitant treatment included glucocorticoids 64% patients, immunoglobulins (33%) rituximab (17%). Remission improvement disease 81% patients. Autoantibody depletion reduction stated 52% Death occurred three (3%). Adverse 45% application-associated reaction (20%), infection (19%) hypogammaglobulinaemia (33%).Targeting CD38 is promising option therapy refractory Efficacy well optimal regimen management prevention require further investigation. Therefore, trials this

Язык: Английский

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The molecular subtypes of autoimmune diseases

Computational and Structural Biotechnology Journal, Год журнала: 2024, Номер 23, С. 1348 - 1363

Опубликована: Март 28, 2024

Autoimmune diseases (ADs) are characterized by their complexity and a wide range of clinical differences. Despite patients presenting with similar symptoms disease patterns, reactions to treatments may vary. The current approach personalized medicine, which relies on molecular data, is seen as an effective method address the variability in these diseases. This review examined pathologic classification ADs, such multiple sclerosis lupus nephritis, over time. Acknowledging limitations inherent classification, focus shifted achieve deeper insight into heterogeneity. study outlined established methods findings from categorizing systemic erythematosus (SLE) four subtypes, inflammatory bowel (IBD) two, rheumatoid arthritis (RA) three, (MS) single subtype. It was observed that high inflammation subtype IBD, RA subtype, MS "inflammation & EGF" share similarities. These subtypes all display consistent pattern primarily driven activation JAK-STAT pathway, drugs being those target this signaling pathway. Additionally, identifying markers uniquely associated various within same disease, able describe differences between detail. expected contribute development treatment plans for establish strong basis tailored approaches treating autoimmune

Язык: Английский

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Application of artificial intelligence in rheumatic disease: a bibliometric analysis

Clinical and Experimental Medicine, Год журнала: 2024, Номер 24(1)

Опубликована: Авг. 23, 2024

The utilization of artificial intelligence (AI) in rheumatic diseases has enhanced the diagnostic accuracy diseases, enabled prediction patient outcomes, expanded treatment options, and facilitated provision individualized medical solutions. research this field been progressively growing recent years. Consequently, there is a need for bibliometric analysis to elucidate current state advancement predominant foci AI applications within diseases. Additionally, it crucial identify key contributors their interrelations field. This study aimed conduct investigate hotspots collaborative networks application disease A comprehensive search was conducted Web Science articles on published SSCI SCI-EXPANDED until January 1, 2024. Utilizing software tools like VOSviewers CiteSpace, we analyzed various parameters including publication year, journal, country, institution, authorship. extended examining cited authors, generating reference citation network graphs, creating co-citation keyword maps. trends domain were evaluated. As 2024, total 3508 have disease, exhibiting steady rise both annual frequency rate. "Scientific Reports" emerged as leading journal terms relevant publications. United States stood out country volume papers, with University California, San Francisco (UCSF) being most prolific frequently institution. Among Young Ho Lee Valentina Pedoia noted significant contributions, achieving highest average count per publication. Machine learning prominent central keyword. trend indicates interest rheumatologic its role expected become increasingly pivotal presents summary developments It offers insights into potential collaborations prospects future research, clarifying frontiers emerging directions findings serve valuable scholars studying rheumatology immunology.

Язык: Английский

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B cell metabolism in autoimmune diseases: signaling pathways and interventions

Frontiers in Immunology, Год журнала: 2023, Номер 14

Опубликована: Авг. 23, 2023

Autoimmune diseases are heterogeneous disorders believed to stem from the immune system’s inability distinguish between auto- and foreign- antigens. B lymphocytes serve a crucial role in humoral immunity as they generate antibodies present Dysregulation of cell function induce onset autoimmune by generating autoantibodies pro-inflammatory cytokines, resulting an imbalance regulation. New research immunometabolism shows that cellular metabolism plays essential controlling reactions providing energy substrates for activation, differentiation, function. However, dysregulated lead disrupting self-tolerance mechanisms. This review summarizes latest on metabolic reprogramming diseases, identifying pathways regulatory factors. Moreover, we consider potential interventions promising therapeutic strategy. Understanding mechanisms cells brings us closer developing novel therapies disorders.

Язык: Английский

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Modern concept of autoimmunity in rheumatology

Rheumatology Science and Practice, Год журнала: 2023, Номер 61(4), С. 397 - 420

Опубликована: Авг. 31, 2023

Two fundamental pathologic processes are central to the spectrum of chronic inflammation mechanisms: autoimmunity and autoinflammation. Autoimmunity autoinflammation mutually potent processes; their development is considered within framework “immunoinflammatory” continuum, reflecting close relationship between innate acquired types immune response. leading mechanism pathogenesis a large group inflammatory human diseases, defined as autoimmune frequency which in population exceeds 10%. Advances molecular biology, pharmacogenetics bioinformatics have created prerequisites for individualization therapy rheumatic diseases concept personalized medicine. The study immunopathogenesis mechanisms, improvement diagnostics, deciphering nature taxonomy, approaches prevention among priority directions medicine 21st century.

Язык: Английский

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A review on pharmacokinetics of sinomenine and its anti-inflammatory and immunomodulatory effects

International Immunopharmacology, Год журнала: 2023, Номер 119, С. 110227 - 110227

Опубликована: Апрель 27, 2023

Язык: Английский

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Beyond very early systemic sclerosis: deciphering pre‑scleroderma and its trajectories to open new avenues for preventive medicine

The Lancet Rheumatology, Год журнала: 2023, Номер 5(11), С. e683 - e694

Опубликована: Сен. 26, 2023

Язык: Английский

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Immunosensors for Autoimmune-Disease-Related Biomarkers: A Literature Review

Sensors, Год журнала: 2023, Номер 23(15), С. 6770 - 6770

Опубликована: Июль 28, 2023

Immunosensors are a special class of biosensors that employ specific antibodies for biorecognition the target analyte. disease biomarkers may be exploited as tools diagnosis and/or follow-up, offering several advantages over conventional analytical techniques, such rapid and easy analysis patients’ samples at point-of-care. Autoimmune diseases have been increasingly prevalent worldwide in recent years, while COVID-19 pandemic has also associated with autoimmunity. Consequently, demand enabling early reliable autoimmune is expected to increase near future. To this end, interest immunosensors targeting biomarkers, mainly, various autoantibodies pro-inflammatory proteins (e.g., cytokines), rekindled. This review article presents most proposed date potential diseases, type 1 diabetes, rheumatoid arthritis, multiple sclerosis. The signal transduction immunoassay principles each immunosensor suitably classified briefly presented along certain sensor elements, e.g., nano-sized materials used construction immunosensing surface. main concluding remarks future perspectives field discussed.

Язык: Английский

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Artemisinins: Promising drug candidates for the treatment of autoimmune diseases

Medicinal Research Reviews, Год журнала: 2023, Номер 44(2), С. 867 - 891

Опубликована: Дек. 6, 2023

Abstract Autoimmune diseases are characterized by the immune system's attack on one's own tissues which highly diverse and differ in severity, causing damage virtually all human systems including connective tissue (e.g., rheumatoid arthritis), neurological system multiple sclerosis) digestive inflammatory bowel disease). Historically, treatments normally include pain‐killing medication, anti‐inflammatory drugs, corticosteroids, immunosuppressant drugs. However, given above characteristics, treatment of autoimmune has always been a challenge. Artemisinin is natural sesquiterpene lactone initially extracted separated from Chinese medicine Artemisia annua L., long history curing malaria. Artemisinin's derivatives such as artesunate, dihydroartemisinin, artemether, artemisitene, so forth, family artemisinins with antimalarial activity. Over past decades, accumulating evidence have indicated promising therapeutic potential diseases. Herein, we systematically summarized research regarding immunoregulatory properties artemisinin its derivatives, discussing their viability toward major underlying mechanisms. This review will provide new directions for basic clinical translational artemisinins.

Язык: Английский

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Coenzyme Q10 and Autoimmune Disorders: An Overview

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(8), С. 4576 - 4576

Опубликована: Апрель 22, 2024

Some 90 autoimmune disorders have been described in medical literature, affecting most of the tissues within body. Autoimmune may be difficult to treat, and there is a need develop novel therapeutic strategies for these disorders. are characterised by mitochondrial dysfunction, oxidative stress, inflammation; therefore rationale role coenzyme Q10 management disorders, on basis its key normal function, as an antioxidant, anti-inflammatory agent. In this article, we reviewed potential CoQ10, terms both deficiency and/or supplementation, range

Язык: Английский

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