Nicotine dependence is associated with an increased risk of developing chronic, non-communicable inflammatory disease: a large-scale retrospective cohort study DOI Creative Commons

Khalaf Kridin,

Cristian Papara, Katja Bieber

et al.

Frontiers in Psychiatry, Journal Year: 2025, Volume and Issue: 16

Published: Feb. 12, 2025

Introduction Chronic, non-communicable inflammatory diseases (CIDs) affect a large portion of the population, imposing significant morbidity, encompassing substantial mortality. Thus, they are major medical burden with high unmet need. CIDs develop over span several years, and risk developing has been linked to genetic environmental factors. modification factors is promising approach for prevention CIDs. Among modifiable that have CID nicotine dependence. However, only few CIDs, compelling evidence suggests dependence increases (e.g., rheumatoid arthritis asthma) or decreases pemphigus) risk. For most there inconsistent, scant, no reports on associated Methods To address this gap, we leveraged TriNetX, analyzing data from 120 million electronic health records (EHRs). Using propensity score matching (PSM) control age, sex, ethnicity, other factors, contrasted any 38 in 881,192 EHRs individuals PSM-matched unexposed counterparts. Results The analytical pipeline was validated by demonstrating an increased exposed subsequent diagnosis myocardial infarction, malignant neoplasm lung, chronic obstructive pulmonary disease. Overall, 16.8% developed compared 9.6% not (hazard ratio 2.12, confidence interval 2.10–2.14, p < 0.0001). Investigating single imposed risks 23 investigated diseases, i.e., dermatomyositis, granulomatosis polyangiitis, pyoderma gangrenosum, immune thrombocytopenic purpura. sex-stratified analysis revealed sex-specific differences Discussion Our study emphasizes importance preventive measures targeting addiction reduce global

Language: Английский

Daratumumab for autoimmune diseases: a systematic review DOI Creative Commons
Marie-Therese Holzer, Nikolas Ruffer, Tobias B. Huber

et al.

RMD Open, Journal Year: 2023, Volume and Issue: 9(4), P. e003604 - e003604

Published: Dec. 1, 2023

Refractory autoimmune diseases remain a significant challenge in clinical practice and new therapeutic options are needed. This systematic review evaluates the existing reported data on CD38-targeting antibody daratumumab as approach autoantibody-mediated diseases.A protocolised literature according to Preferred Reporting Items for Systematic Reviews Meta-Analyses guidelines was performed. Two databases (Medline Embase) were searched suitable studies. Usage of non-oncological or non-transplantation associated with pathophysiology analysed including patient characteristics, regimen, adverse events outcome.38 publications reporting course 83 patients met inclusion criteria. Daratumumab usage therapy-refractory cases (median 5 different previous therapies) 24 diseases. The median number applications 4, mainly via intravenous (87%). Concomitant treatment included glucocorticoids 64% patients, immunoglobulins (33%) rituximab (17%). Remission improvement disease 81% patients. Autoantibody depletion reduction stated 52% Death occurred three (3%). Adverse 45% application-associated reaction (20%), infection (19%) hypogammaglobulinaemia (33%).Targeting CD38 is promising option therapy refractory Efficacy well optimal regimen management prevention require further investigation. Therefore, trials this

Language: Английский

Citations

21
The molecular subtypes of autoimmune diseases DOI Creative Commons

Xiangshu Cheng,

Xin Meng, Rui Chen

et al.

Computational and Structural Biotechnology Journal, Journal Year: 2024, Volume and Issue: 23, P. 1348 - 1363

Published: March 28, 2024

Autoimmune diseases (ADs) are characterized by their complexity and a wide range of clinical differences. Despite patients presenting with similar symptoms disease patterns, reactions to treatments may vary. The current approach personalized medicine, which relies on molecular data, is seen as an effective method address the variability in these diseases. This review examined pathologic classification ADs, such multiple sclerosis lupus nephritis, over time. Acknowledging limitations inherent classification, focus shifted achieve deeper insight into heterogeneity. study outlined established methods findings from categorizing systemic erythematosus (SLE) four subtypes, inflammatory bowel (IBD) two, rheumatoid arthritis (RA) three, (MS) single subtype. It was observed that high inflammation subtype IBD, RA subtype, MS "inflammation & EGF" share similarities. These subtypes all display consistent pattern primarily driven activation JAK-STAT pathway, drugs being those target this signaling pathway. Additionally, identifying markers uniquely associated various within same disease, able describe differences between detail. expected contribute development treatment plans for establish strong basis tailored approaches treating autoimmune

Language: Английский

Citations

6
Application of artificial intelligence in rheumatic disease: a bibliometric analysis DOI Creative Commons
Junkang Zhao, Linxin Li, Jie Li

et al.

Clinical and Experimental Medicine, Journal Year: 2024, Volume and Issue: 24(1)

Published: Aug. 23, 2024

The utilization of artificial intelligence (AI) in rheumatic diseases has enhanced the diagnostic accuracy diseases, enabled prediction patient outcomes, expanded treatment options, and facilitated provision individualized medical solutions. research this field been progressively growing recent years. Consequently, there is a need for bibliometric analysis to elucidate current state advancement predominant foci AI applications within diseases. Additionally, it crucial identify key contributors their interrelations field. This study aimed conduct investigate hotspots collaborative networks application disease A comprehensive search was conducted Web Science articles on published SSCI SCI-EXPANDED until January 1, 2024. Utilizing software tools like VOSviewers CiteSpace, we analyzed various parameters including publication year, journal, country, institution, authorship. extended examining cited authors, generating reference citation network graphs, creating co-citation keyword maps. trends domain were evaluated. As 2024, total 3508 have disease, exhibiting steady rise both annual frequency rate. "Scientific Reports" emerged as leading journal terms relevant publications. United States stood out country volume papers, with University California, San Francisco (UCSF) being most prolific frequently institution. Among Young Ho Lee Valentina Pedoia noted significant contributions, achieving highest average count per publication. Machine learning prominent central keyword. trend indicates interest rheumatologic its role expected become increasingly pivotal presents summary developments It offers insights into potential collaborations prospects future research, clarifying frontiers emerging directions findings serve valuable scholars studying rheumatology immunology.

Language: Английский

Citations

6
B cell metabolism in autoimmune diseases: signaling pathways and interventions DOI Creative Commons
Jingyue Li,

Mingjiu Zhao,

Wenjun Luo

et al.

Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14

Published: Aug. 23, 2023

Autoimmune diseases are heterogeneous disorders believed to stem from the immune system’s inability distinguish between auto- and foreign- antigens. B lymphocytes serve a crucial role in humoral immunity as they generate antibodies present Dysregulation of cell function induce onset autoimmune by generating autoantibodies pro-inflammatory cytokines, resulting an imbalance regulation. New research immunometabolism shows that cellular metabolism plays essential controlling reactions providing energy substrates for activation, differentiation, function. However, dysregulated lead disrupting self-tolerance mechanisms. This review summarizes latest on metabolic reprogramming diseases, identifying pathways regulatory factors. Moreover, we consider potential interventions promising therapeutic strategy. Understanding mechanisms cells brings us closer developing novel therapies disorders.

Language: Английский

Citations

16
Modern concept of autoimmunity in rheumatology DOI Creative Commons
Е. Л. Насонов

Rheumatology Science and Practice, Journal Year: 2023, Volume and Issue: 61(4), P. 397 - 420

Published: Aug. 31, 2023

Two fundamental pathologic processes are central to the spectrum of chronic inflammation mechanisms: autoimmunity and autoinflammation. Autoimmunity autoinflammation mutually potent processes; their development is considered within framework “immunoinflammatory” continuum, reflecting close relationship between innate acquired types immune response. leading mechanism pathogenesis a large group inflammatory human diseases, defined as autoimmune frequency which in population exceeds 10%. Advances molecular biology, pharmacogenetics bioinformatics have created prerequisites for individualization therapy rheumatic diseases concept personalized medicine. The study immunopathogenesis mechanisms, improvement diagnostics, deciphering nature taxonomy, approaches prevention among priority directions medicine 21st century.

Language: Английский

Citations

16
A review on pharmacokinetics of sinomenine and its anti-inflammatory and immunomodulatory effects DOI
Siwei Wang, Lvzhuo Zhang,

Yanhua Zhou

et al.

International Immunopharmacology, Journal Year: 2023, Volume and Issue: 119, P. 110227 - 110227

Published: April 27, 2023

Language: Английский

Citations

15
Beyond very early systemic sclerosis: deciphering pre‑scleroderma and its trajectories to open new avenues for preventive medicine DOI Creative Commons

Alain Lescoat,

Silvia Bellando-Randone, Corrado Campochiaro

et al.

The Lancet Rheumatology, Journal Year: 2023, Volume and Issue: 5(11), P. e683 - e694

Published: Sept. 26, 2023

Language: Английский

Citations

15
Immunosensors for Autoimmune-Disease-Related Biomarkers: A Literature Review DOI Creative Commons
Chrysoula‐Evangelia Karachaliou, Evangelia Livaniou

Sensors, Journal Year: 2023, Volume and Issue: 23(15), P. 6770 - 6770

Published: July 28, 2023

Immunosensors are a special class of biosensors that employ specific antibodies for biorecognition the target analyte. disease biomarkers may be exploited as tools diagnosis and/or follow-up, offering several advantages over conventional analytical techniques, such rapid and easy analysis patients’ samples at point-of-care. Autoimmune diseases have been increasingly prevalent worldwide in recent years, while COVID-19 pandemic has also associated with autoimmunity. Consequently, demand enabling early reliable autoimmune is expected to increase near future. To this end, interest immunosensors targeting biomarkers, mainly, various autoantibodies pro-inflammatory proteins (e.g., cytokines), rekindled. This review article presents most proposed date potential diseases, type 1 diabetes, rheumatoid arthritis, multiple sclerosis. The signal transduction immunoassay principles each immunosensor suitably classified briefly presented along certain sensor elements, e.g., nano-sized materials used construction immunosensing surface. main concluding remarks future perspectives field discussed.

Language: Английский

Citations

11
Artemisinins: Promising drug candidates for the treatment of autoimmune diseases DOI

Xu Gao,

Xian Lin, Qingwen Wang

et al.

Medicinal Research Reviews, Journal Year: 2023, Volume and Issue: 44(2), P. 867 - 891

Published: Dec. 6, 2023

Abstract Autoimmune diseases are characterized by the immune system's attack on one's own tissues which highly diverse and differ in severity, causing damage virtually all human systems including connective tissue (e.g., rheumatoid arthritis), neurological system multiple sclerosis) digestive inflammatory bowel disease). Historically, treatments normally include pain‐killing medication, anti‐inflammatory drugs, corticosteroids, immunosuppressant drugs. However, given above characteristics, treatment of autoimmune has always been a challenge. Artemisinin is natural sesquiterpene lactone initially extracted separated from Chinese medicine Artemisia annua L., long history curing malaria. Artemisinin's derivatives such as artesunate, dihydroartemisinin, artemether, artemisitene, so forth, family artemisinins with antimalarial activity. Over past decades, accumulating evidence have indicated promising therapeutic potential diseases. Herein, we systematically summarized research regarding immunoregulatory properties artemisinin its derivatives, discussing their viability toward major underlying mechanisms. This review will provide new directions for basic clinical translational artemisinins.

Language: Английский

Citations

11
Coenzyme Q10 and Autoimmune Disorders: An Overview DOI Open Access

David Mantle,

Iain P. Hargreaves

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(8), P. 4576 - 4576

Published: April 22, 2024

Some 90 autoimmune disorders have been described in medical literature, affecting most of the tissues within body. Autoimmune may be difficult to treat, and there is a need develop novel therapeutic strategies for these disorders. are characterised by mitochondrial dysfunction, oxidative stress, inflammation; therefore rationale role coenzyme Q10 management disorders, on basis its key normal function, as an antioxidant, anti-inflammatory agent. In this article, we reviewed potential CoQ10, terms both deficiency and/or supplementation, range

Language: Английский

Citations

4