The Innovation Medicine,
Год журнала:
2024,
Номер
unknown, С. 100094 - 100094
Опубликована: Янв. 1, 2024
<p>Bladder
cancer
(BCa)
is
the
most
common
and
lethal
urological
malignancy.
Lymphatic
metastasis
main
type
of
a
poor
prognostic
factor
for
bladder
patients.
Although
several
treatments
are
approved
BCa
patients,
some
patients
still
resistant
to
current
therapy.
The
tumor
microenvironment
(TME),
which
consists
diverse
cellular
components,
crucial
mediator
progression
treatment
resistance.
However,
literature
on
interactions
between
TME
lacks
coherence
systematic
analysis,
while
impact
intratumoral
heterogeneity
(ITH)
tumorigenesis
has
not
been
fully
summarized.
Iterative
insights
into
factors
intrinsic
extrinsic
cells
that
regulate
response
critically
needed.
Here,
we
provide
an
overview
knowledge
multilevel
crosstalk
TME,
including
protein-coding
genes
epigenetic
in
cells,
tumor-associated
macrophages
(TAMs),
cancer-associated
fibroblasts
(CAFs),
neutrophils
(TANs),
endothelial
(ECs),
lymphatic
(LECs)
other
play
roles
tumorigenesis,
progression,
development
drug
We
also
summarize
advanced
therapeutic
approaches
targeting
discuss
challenges
future
perspectives
associated
with
therapies.</p>
Cancer Letters,
Год журнала:
2024,
Номер
591, С. 216894 - 216894
Опубликована: Апрель 16, 2024
This
comprehensive
review
delves
into
the
pivotal
role
of
tumor
microenvironment
(TME)
in
cancer
metastasis
and
therapeutic
response,
offering
fresh
insights
intricate
interplay
between
cells
their
surrounding
milieu.
The
TME,
a
dynamic
ecosystem
comprising
diverse
cellular
acellular
elements,
not
only
fosters
progression
but
also
profoundly
affects
efficacy
conventional
emerging
therapies.
Through
nuanced
exploration,
this
illuminates
multifaceted
nature
elucidating
its
capacity
to
engender
drug
resistance
via
mechanisms
such
as
hypoxia,
immune
evasion,
establishment
physical
barriers
delivery.
Moreover,
it
investigates
innovative
approaches
aimed
at
targeting
including
stromal
reprogramming,
modulation,
extracellular
matrix
(ECM)-targeting
agents,
personalized
medicine
strategies,
highlighting
potential
augment
treatment
outcomes.
Furthermore,
critically
evaluates
challenges
posed
by
complexity
heterogeneity
which
contribute
variable
responses
potentially
unintended
consequences.
underscores
need
identify
robust
biomarkers
advance
predictive
models
anticipate
outcomes,
well
advocate
for
combination
therapies
that
address
multiple
facets
TME.
Finally,
emphasizes
necessity
an
interdisciplinary
approach
integration
cutting-edge
technologies
unravel
intricacies
thereby
facilitating
development
more
effective,
adaptable,
treatments.
By
providing
critical
current
state
TME
research
implications
future
oncology,
highlights
evolving
landscape
field.
Journal of Hematology & Oncology,
Год журнала:
2025,
Номер
18(1)
Опубликована: Янв. 13, 2025
The
tumor
microenvironment
(TME)
is
integral
to
cancer
progression,
impacting
metastasis
and
treatment
response.
It
consists
of
diverse
cell
types,
extracellular
matrix
components,
signaling
molecules
that
interact
promote
growth
therapeutic
resistance.
Elucidating
the
intricate
interactions
between
cells
TME
crucial
in
understanding
progression
challenges.
A
critical
process
induced
by
epithelial-mesenchymal
transition
(EMT),
wherein
epithelial
acquire
mesenchymal
traits,
which
enhance
their
motility
invasiveness
progression.
By
targeting
various
components
TME,
novel
investigational
strategies
aim
disrupt
TME's
contribution
EMT,
thereby
improving
efficacy,
addressing
resistance,
offering
a
nuanced
approach
therapy.
This
review
scrutinizes
key
players
emphasizing
avenues
therapeutically
components.
Moreover,
article
discusses
implications
for
resistance
mechanisms
highlights
current
toward
modulation
along
with
potential
caveats.
Advanced Therapeutics,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 6, 2025
Abstract
The
extracellular
matrix
(ECM)
serves
not
only
as
a
structural
scaffold
but
also
an
active
regulator
of
cancer
progression,
profoundly
influencing
tumor
behaviour
and
the
microenvironment
(TME).
This
review
focuses
into
pivotal
role
ECM
alterations
in
facilitating
metastasis
explores
therapeutic
strategies
aimed
at
counteracting
these
changes.
We
analyse
targeted
interventions
against
collagen,
including
approaches
to
inhibit
its
biosynthesis
disrupt
associated
signalling
pathways
critical
for
architecture
cell
migration.
Additionally,
therapies
addressing
hyaluronan
are
reviewed,
highlighting
methods
suppress
synthesis
enzymatic
degrade
it,
thereby
mitigating
tumor‐promoting
effects.
discussion
extends
innovative
modulating
stiffness,
focusing
on
roles
cancer‐associated
fibroblasts
lysyl
oxidases,
which
key
contributors
remodelling
mechanical
signalling.
By
strategically
modifying
components,
aim
enhance
efficacy
existing
treatments,
tackle
resistance
mechanisms,
achieve
more
durable
outcomes.
Insights
from
recent
studies
clinical
trials
highlight
promise
overcoming
treatment
improving
patient
Advancing
our
understanding
biology
leads
development
effective
therapies.
Frontiers in Immunology,
Год журнала:
2024,
Номер
15
Опубликована: Апрель 2, 2024
Background
T
cell
exhaustion
in
the
tumor
microenvironment
has
been
demonstrated
as
a
substantial
contributor
to
immunosuppression
and
progression.
However,
correlation
between
osteosarcoma
(OS)
remains
unclear.
Methods
In
our
present
study,
single-cell
RNA-seq
data
for
OS
from
GEO
database
was
analysed
identify
CD8+
cells
discern
subsets
objectively.
Subgroup
differentiation
trajectory
then
used
pinpoint
genes
altered
response
exhaustion.
Subsequently,
six
machine
learning
algorithms
were
applied
develop
prognostic
model
linked
with
This
subsequently
validated
TARGETs
Meta
cohorts.
Finally,
we
examined
disparities
immune
infiltration,
checkpoints,
immune-related
pathways,
efficacy
of
immunotherapy
high
low
TEX
score
groups.
Results
The
findings
unveiled
differential
within
microenvironment.
Three
related
(RAD23A,
SAC3D1,
PSIP1)
identified
employed
formulate
model.
exhibited
robust
predictive
capabilities
prognosis,
patients
group
demonstrating
more
favorable
increased
heightened
responsiveness
treatment
compared
those
group.
Conclusion
summary,
research
elucidates
role
progression
OS,
constructed
based
on
exhaustion-related
holds
promise
potential
method
prognostication
management
patients.
Expert Opinion on Therapeutic Targets,
Год журнала:
2023,
Номер
27(6), С. 447 - 457
Опубликована: Июнь 3, 2023
Introduction
Cancer
development
and
progression
is
a
complex
process
influenced
by
co-evolution
of
the
cancer
cells
their
microenvironment.
However,
traditional
anti-cancer
therapy
mostly
targeted
toward
cells.
To
improve
efficacy
drugs,
interactions
between
tumor
(T)
microenvironment
(TME)
should
be
considered
while
developing
therapeutics.
Scientific Reports,
Год журнала:
2025,
Номер
15(1)
Опубликована: Фев. 19, 2025
Topoisomerases
are
critical
nuclear
enzymes
that
resolve
DNA
topological
challenges
during
genetic
processes.
However,
there
is
currently
a
lack
of
comprehensive
multi-omics
analysis
TOP2A
from
pan-cancer
perspective,
despite
its
significance.
A
multiomics
was
conducted
to
investigate
across
various
cancer
types.
This
study
involved
the
integration
over
10,000
multidimensional
genomic
datasets
33
distinct
types,
obtained
The
Cancer
Genome
Atlas
(TCGA).
focused
on
evaluating
overall
activity
levels
in
pan-cancers,
which
encompassed
differential
expression,
clinical
significance,
immune
cell
infiltration,
and
regulation
pathways
related
cancer.
Aberrant
epigenetic
modifications
alterations
have
been
identified
as
being
associated
with
dysregulation
expression
levels.
These
molecular
changes
substantial
impacts
progression,
intratumoral
heterogeneity,
immunological
status,
biomarkers.
Consequently,
patient
prognosis
varies
significantly
based
presence
specific
nature
these
alterations.
potential
serve
novel
biomarker
for
may
offer
valuable
insights
into
diagnosis
treatment
Cell Death and Disease,
Год журнала:
2024,
Номер
15(9)
Опубликована: Сен. 20, 2024
Mesenchymal
stem
cells
(MSCs)
in
tumor
microenvironment
(TME)
are
crucial
for
the
initiation,
development,
and
metastasis
of
cancer.
The
impact
mechanism
MSCs
on
bladder
cancer
uncertain.
Here
we
analyzed
205
patient
samples
to
explore
relationships
between
tumor-stroma
ratio
clinicopathological
features.
A
co-culture
model
nude
mouse
transplantation
were
used
biological
roles
molecular
mechanisms
cells.
We
found
that
a
high
was
significantly
associated
with
larger
size
higher
T
stage,
pathological
grade,
number
vascular
invasions,
poor
overall
survival.
TME
promoted
ability
proliferate,
migrate,
invade
vitro
vivo.
Next,
demonstrated
enhance
mitochondrial
autophagy
biogenesis
cells,
increase
energy
production,
thereby
promoting
cell
progression.
Kynurenine
(Kyn)
produced
by
could
function
activating
AMPK
pathway.
IDO1
inhibitor
reverse
tumor‑promoting
effects
Our
results
tryptophan
metabolites
Kyn
pathway,
