Oxidative stress in Alzheimer’s disease: current knowledge of signaling pathways and therapeutics

Molecular Biology Reports, Год журнала: 2024, Номер 51(1)

Опубликована: Янв. 2, 2024

Язык: Английский

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Mitochondria in Alzheimer’s Disease Pathogenesis

Life, Год журнала: 2024, Номер 14(2), С. 196 - 196

Опубликована: Янв. 30, 2024

Alzheimer’s disease (AD) is a progressive and incurable neurodegenerative disorder that primarily affects persons aged 65 years above. It causes dementia with memory loss deterioration in thinking language skills. AD characterized by specific pathology resulting from the accumulation brain of extracellular plaques amyloid-β intracellular tangles phosphorylated tau. The importance mitochondrial dysfunction pathogenesis, while previously underrecognized, now more appreciated. Mitochondria are an essential organelle involved cellular bioenergetics signaling pathways. Mitochondrial processes crucial for synaptic activity such as mitophagy, trafficking, fission, fusion dysregulated brain. Excess fission fragmentation yield mitochondria low energy production. Reduced glucose metabolism also observed hypometabolic state, particularly temporo-parietal regions. This review addresses multiple ways which abnormal structure function contribute to AD. Disruption electron transport chain ATP production neurotoxic because cells have disproportionately high demands. In addition, oxidative stress, extremely damaging nerve cells, rises dramatically dyshomeostasis. Restoring health may be viable approach treatment.

Язык: Английский

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The interplay between mitochondrial dynamics and autophagy: From a key homeostatic mechanism to a driver of pathology

Seminars in Cell and Developmental Biology, Год журнала: 2024, Номер 161-162, С. 1 - 19

Опубликована: Март 1, 2024

The complex relationship between mitochondrial dynamics and autophagy illustrates how two cellular housekeeping processes are intimately linked, illuminating fundamental principles of homeostasis shedding light on disparate pathological conditions including several neurodegenerative disorders. Here we review the basic tenets i.e., concerted balance fusion fission organelle, its interplay with macroautophagy selective autophagy, also dubbed mitophagy, in maintenance quality control ultimately cell viability. We illustrate altered reverberate vice versa. Finally, these key participates pathogenesis human disorders affecting multiple organs systems.

Язык: Английский

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Endoplasmic reticulum stress in Alzheimer's disease: Molecular mechanisms and therapeutic prospects

Life Sciences, Год журнала: 2023, Номер 330, С. 121983 - 121983

Опубликована: Июль 29, 2023

Язык: Английский

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The link between metabolic syndrome and Alzheimer disease: A mutual relationship and long rigorous investigation

Ageing Research Reviews, Год журнала: 2023, Номер 91, С. 102084 - 102084

Опубликована: Окт. 5, 2023

Язык: Английский

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Drp1 and neuroinflammation: Deciphering the interplay between mitochondrial dynamics imbalance and inflammation in neurodegenerative diseases

Neurobiology of Disease, Год журнала: 2024, Номер 198, С. 106561 - 106561

Опубликована: Июнь 9, 2024

Neuroinflammation and mitochondrial dysfunction are closely intertwined with the pathophysiology of neurological disorders. Recent studies have elucidated profound alterations in dynamics across a spectrum Dynamin-related protein 1 (DRP1) emerges as pivotal regulator fission, its dysregulation disrupting homeostasis fueling neuroinflammation, thereby exacerbating disease severity. In addition to role dynamics, DRP1 plays crucial modulating inflammation-related pathways. This review synthesizes important functions central nervous system (CNS) impact epigenetic modification on progression neurodegenerative diseases. The intricate interplay between neuroinflammation microglia astrocytes, contributors is expounded upon. Furthermore, use inhibitors influence activation well their involvement processes such mitophagy, oxidative stress, calcium ion transport CNS-mediated scrutinized. modulation astrocyte crosstalk by inflammatory neurodegeneration also highlighted. Overall, targeting presents promising avenue for ameliorating enhancing therapeutic management

Язык: Английский

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Advancements in autophagy perturbations in Alzheimer’s disease: Molecular aspects and therapeutics

Brain Research, Год журнала: 2025, Номер 1851, С. 149494 - 149494

Опубликована: Фев. 6, 2025

Язык: Английский

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Understanding the neuronal synapse and challenges associated with the mitochondrial dysfunction in mild cognitive impairment and Alzheimer’s disease

Mitochondrion, Год журнала: 2023, Номер 73, С. 19 - 29

Опубликована: Сен. 12, 2023

Язык: Английский

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Implicative role of cytokines in neuroinflammation mediated AD and associated signaling pathways: Current progress in molecular signaling and therapeutics

Ageing Research Reviews, Год журнала: 2023, Номер 92, С. 102098 - 102098

Опубликована: Окт. 30, 2023

Язык: Английский

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The Potential of Mitochondrial Therapeutics in the Treatment of Oxidative Stress and Inflammation in Aging

Molecular Neurobiology, Год журнала: 2024, Номер unknown

Опубликована: Сен. 4, 2024

Язык: Английский

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