Schizophrenia Bulletin, Год журнала: 2024, Номер unknown
Опубликована: Ноя. 13, 2024
The complex immune-brain interactions and the regulatory role of mitochondria in immune response suggest that mitochondrial damage reported schizophrenia (SZ) may be related to abnormalities observed brain functions.
Язык: Английский
Functional & Integrative Genomics, Год журнала: 2025, Номер 25(1)
Опубликована: Янв. 23, 2025
Язык: Английский
Процитировано
3
GeroScience, Год журнала: 2024, Номер 46(5), С. 4275 - 4314
Опубликована: Апрель 1, 2024
Down syndrome (DS) is a genetic condition where the person born with an extra chromosome 21. DS associated accelerated aging; people are prone to age-related neurological conditions including early-onset Alzheimer's disease. Using Dp(17)3Yey/ + mice, which overexpresses portion of mouse 17, encodes for transsulfuration enzyme cystathionine β-synthase (CBS), we investigated functional role CBS/hydrogen sulfide (H
Язык: Английский
Процитировано
8
Molecular Neurodegeneration, Год журнала: 2025, Номер 20(1)
Опубликована: Март 4, 2025
The relationship between Alzheimer's disease (AD) and neuroimmunity has gradually begun to be unveiled. Emerging evidence indicates that cyclic GMP-AMP synthase (cGAS) acts as a cytosolic DNA sensor, recognizing damage-associated molecular patterns (DAMPs), inducing the innate immune response by activating stimulator of interferon genes (STING). Dysregulation this pathway culminates in AD-related neuroinflammation neurodegeneration. A substantial body mitochondria are involved critical pathogenic mechanisms AD, whose damage leads release mitochondrial (mtDNA) into extramitochondrial space. This leaked mtDNA serves DAMP, various pattern recognition receptors defense networks brain, including cGAS-STING pathway, ultimately leading an imbalance homeostasis. Therefore, modulation mtDNA-cGAS-STING restore neuroimmune homeostasis may offer promising prospects for improving AD treatment outcomes. In review, we focus on during stress activation pathway. Additionally, delve research progress further discuss primary directions potential hurdles developing targeted therapeutic drugs, gain deeper understanding pathogenesis provide new approaches its therapy.
Язык: Английский
Процитировано
1
Journal of Ethnopharmacology, Год журнала: 2025, Номер unknown, С. 119424 - 119424
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0
Cells, Год журнала: 2025, Номер 14(3), С. 206 - 206
Опубликована: Янв. 30, 2025
Multiple sclerosis (MS) is an inflammatory autoimmune disease of the central nervous system (CNS) linked to many neurological disabilities. The visual frequently impaired in MS. In previous studies, we observed early malfunctions rod photoreceptor ribbon synapses EAE mouse model MS that included alterations synaptic vesicle cycling and disturbances presynaptic Ca2+ homeostasis. Since these events are highly energy-demanding, analyzed whether mitochondria, which play a major role energy metabolism, might be involved at stage. Rod terminals contain single large mitochondrion next ribbon. present study, expression functionally relevant mitochondrial proteins (MIC60, ATP5B, COX1, PINK1, DRP1) by high-resolution qualitative quantitative immunofluorescence microscopy, immunogold electron microscopy Western blot experiments. We decreased mitochondria photoreceptors stage, suggesting dysfunctions important synapse pathology. Interestingly, were strongly compromised EAE, whereas extra-synaptic inner segments remained unchanged, demonstrating functional heterogeneity mitochondria.
Язык: Английский
Процитировано
0
Open Medicine, Год журнала: 2024, Номер 19(1)
Опубликована: Янв. 1, 2024
Abstract Mitochondria-derived reactive oxygen species production at a moderate physiological level plays fundamental role in the anti-aging signaling, due to their action as redox-active sensors for maintenance of optimal mitochondrial balance between intracellular energy status and hormetic nutrients. Iron regulatory protein dysregulation, systematically increased iron levels, dysfunction, consequent oxidative stress are recognized underlie pathogenesis multiple neurodegenerative diseases, such Parkinson’s disease Alzheimer’s disease. Central pathogenesis, Nrf2 signaling dysfunction occurs with disruption metabolic homeostasis. We highlight potential therapeutic importance nutritional polyphenols substantive regulators pathway. Here, we discuss common mechanisms targeting Nrf2/vitagene pathway, novel strategies minimize consequences neuroinflammation, generally associated cognitive demonstrate its key neuroprotective anti-neuroinflammatory properties, summarizing pharmacotherapeutic aspects relevant brain pathophysiology.
Язык: Английский
Процитировано
3
Brain, Год журнала: 2024, Номер 147(8), С. 2691 - 2705
Опубликована: Июль 5, 2024
Early pathological upregulation of adenosine A2A receptors (A2ARs), one the caffeine targets, by neurons is thought to be involved in development synaptic and memory deficits Alzheimer's disease (AD) but mechanisms remain ill-defined. To tackle this question, we promoted a neuronal A2AR hippocampus APP/PS1 mice developing AD-like amyloidogenesis. Our findings revealed that early presence an ongoing amyloid pathology exacerbates impairments mice. These behavioural changes were not linked major change rather associated with increased phosphorylated tau at neuritic plaques. Moreover, proteomic transcriptomic analyses coupled quantitative immunofluorescence studies indicated receptor both non-neuronal autonomous alterations, i.e. enhanced neuroinflammatory response also loss excitatory synapses impaired mitochondrial function, presumably accounting for detrimental effect on memory. Overall, our results provide compelling evidence dysfunction, as seen brain patients, contributes amyloid-related pathogenesis underscores potential relevant therapeutic target mitigating cognitive neurodegenerative disorder.
Язык: Английский
Процитировано
3
Molecular Neurobiology, Год журнала: 2024, Номер 61(10), С. 8320 - 8343
Опубликована: Март 16, 2024
Язык: Английский
Процитировано
2
Reproductive Biology and Endocrinology, Год журнала: 2024, Номер 22(1)
Опубликована: Июнь 7, 2024
Abstract Fatigue, an increasingly acknowledged symptom in various chronic diseases, has garnered heightened attention, during the medical era of bio-psycho-social model. Its persistence not only significantly compromises individual’s quality life but also correlates with organ damage. Surprisingly, intricate relationship between fatigue and female reproductive health, specifically infertility, remains largely unexplored. Our exploration into existing body evidence establishes a compelling link uterine ovarian as well conditions associated such rheumatism. This observation suggests potentially pivotal role influencing overall fertility. Furthermore, we propose hypothetical mechanism elucidating impact on infertility from multiple perspectives, postulating that neuroendocrine, neurotransmitter, inflammatory immune, mitochondrial dysfunction resulting its co-factors may further contribute to endocrine disorders, menstrual irregularities, sexual dysfunction, ultimately leading infertility. In addition providing this comprehensive theoretical framework, summarize anti-fatigue strategies accentuate current knowledge gaps. By doing so, our aim is offer novel insights, stimulate research, advance understanding crucial interplay health.
Язык: Английский
Процитировано
2
Biomedicine & Pharmacotherapy, Год журнала: 2024, Номер 177, С. 117011 - 117011
Опубликована: Июнь 24, 2024
Microglia are essential for maintaining homeostasis and responding to pathological events in the central nervous system (CNS). Their dynamic multidimensional states different environments pivotal factors various CNS disorders. However, therapeutic modulation of microglial is challenging due intricate balance these cells maintain environment blood-brain barrier's restriction drug delivery. Nanomedicine presents a promising avenue addressing challenges, offering method targeted efficient states. This review covers challenges faced potential use nanoparticle-based delivery systems. We provide an in-depth examination nanoparticle applications modulating range disorders, encompassing neurodegenerative autoimmune diseases, infections, traumatic injuries, stroke, tumors, chronic pain, psychiatric conditions. highlights recent advancements future prospects nanomedicine modulation, paving way research clinical interventions
Язык: Английский
Процитировано
2