Naunyn-Schmiedeberg s Archives of Pharmacology, Год журнала: 2024, Номер unknown
Опубликована: Ноя. 16, 2024
Язык: Английский
Seminars in Cancer Biology, Год журнала: 2024, Номер unknown
Опубликована: Дек. 1, 2024
Elevated lipid metabolism is one of hallmarks malignant tumors. Lipids not only serve as essential structural components biological membranes but also provide energy and substrates for the proliferation cancer cells tumor growth. Cancer meet their needs by coordinating processes absorption, synthesis, transport, storage, catabolism. As research in this area continues to deepen, numerous new discoveries have emerged, making it crucial scientists stay informed about developments metabolism. In review, we first discuss relevant concepts theories or assumptions that help us understand -based therapies. We then systematically summarize latest advancements including mechanisms, novel targets, up-to-date pre-clinical clinical investigations anti-cancer treatment with targeted drugs. Finally, emphasize emerging directions therapeutic strategies, future prospective challenges. This review aims insights guidance field
Язык: Английский
Процитировано
5
Pharmacological Research, Год журнала: 2025, Номер unknown, С. 107648 - 107648
Опубликована: Фев. 1, 2025
Язык: Английский
Процитировано
0
Biology Direct, Год журнала: 2025, Номер 20(1)
Опубликована: Апрель 11, 2025
Язык: Английский
Процитировано
0
International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(8), С. 3716 - 3716
Опубликована: Апрель 15, 2025
A significant challenge in cancer treatment is the rising problem of drug resistance that reduces effectiveness therapeutic strategies. Current knowledge shows multiple mechanisms play a role resistance. Another mechanism has gained attention alteration sphingolipid trafficking and dysregulation its metabolism, which was reported to cause cancer-associated Sphingolipids are lipids containing sphingosine have roles, ranging from lipid raft formation, apoptosis, cell signaling immune trafficking. Recent studies show developing cells, altered or dysregulated sphingolipids associated with efflux promote survival cells by bypassing apoptosis. Upregulated levels glucosylceramide synthase (GCS), an enzyme functions lead upregulated ABCB1 gene induces cells. These bypass make drugs induce apoptosis tumor ineffective. By highlighting current findings, this review aims provide caused synthase, kinase, acid ceramidase enzymes as possible targets enhance currently used chemotherapeutic agents.
Язык: Английский
Процитировано
0
Frontiers in Pharmacology, Год журнала: 2025, Номер 16
Опубликована: Апрель 25, 2025
Hepatocellular carcinoma (HCC) has a relatively poor prognosis and high degree of malignancy. However, the therapeutic drugs are limited. In recent years, abnormal lipid metabolism its important role in HCC been reported, emerging studies found that some formulae active components traditional Chinese medicine (TCM) can regulate HCC, showing their good application prospects. Therefore, this article summarizes changes roles metabolites progression, discusses TCM for treatment based on regulation metabolism. A deeper understanding relationship may help precise use these HCC.
Язык: Английский
Процитировано
0
Frontiers in Immunology, Год журнала: 2024, Номер 15
Опубликована: Ноя. 22, 2024
Sphingolipids, particularly sphingosine-1-phosphate (S1P), are bioactive lipids involved in regulating cellular processes such as proliferation, apoptosis, inflammation, and tumor progression. Alkaline ceramidase 2 (ACER2) plays a critical role sphingolipid metabolism by catalyzing the hydrolysis of ceramide to sphingosine, which is subsequently converted S1P. Dysregulation ACER2 has been implicated various gastrointestinal cancers, including colorectal cancer, gastric hepatocellular carcinoma. ACER2-mediated signaling, through SphK/S1P pathway, influences cancer development modulating immune responses, balance between cell survival death. This review examines physiological functions ACER2, its metabolism, contribution pathogenesis cancers. Understanding mechanisms regulates progression modulation may open new avenues for targeted therapies malignancies.
Язык: Английский
Процитировано
1
Naunyn-Schmiedeberg s Archives of Pharmacology, Год журнала: 2024, Номер unknown
Опубликована: Ноя. 16, 2024
Язык: Английский
Процитировано
0