Unleashing the potential of Genistein and its derivatives as effective therapeutic agents for breast cancer treatment DOI
Eskandar Qaed, Wu Liu,

Marwan Almoiliqy

et al.

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 16, 2024

Language: Английский

Theoretical Framework and Emerging Challenges of Lipid Metabolism in Cancer DOI Creative Commons
Qiuying Gu, Yuan Wang, Ping Yi

et al.

Seminars in Cancer Biology, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 1, 2024

Elevated lipid metabolism is one of hallmarks malignant tumors. Lipids not only serve as essential structural components biological membranes but also provide energy and substrates for the proliferation cancer cells tumor growth. Cancer meet their needs by coordinating processes absorption, synthesis, transport, storage, catabolism. As research in this area continues to deepen, numerous new discoveries have emerged, making it crucial scientists stay informed about developments metabolism. In review, we first discuss relevant concepts theories or assumptions that help us understand -based therapies. We then systematically summarize latest advancements including mechanisms, novel targets, up-to-date pre-clinical clinical investigations anti-cancer treatment with targeted drugs. Finally, emphasize emerging directions therapeutic strategies, future prospective challenges. This review aims insights guidance field

Language: Английский

Citations

5
The Essential Role of Sphingolipids in TRPC5 Ion Channel Localization and Functionality within Lipid Rafts DOI Creative Commons

Junliang Wan,

Zhenying Hu, Huaiyi Zhu

et al.

Pharmacological Research, Journal Year: 2025, Volume and Issue: unknown, P. 107648 - 107648

Published: Feb. 1, 2025

Language: Английский

Citations

0
Lipidome atlas of p53 mutant variants in pancreatic cancer DOI Creative Commons

Kian Cotton,

Charley Comer, Sabrina Caporali

et al.

Biology Direct, Journal Year: 2025, Volume and Issue: 20(1)

Published: April 11, 2025

Language: Английский

Citations

0
Drug Resistance: The Role of Sphingolipid Metabolism DOI Open Access
Assem Zhakupova,

Adelina Zeinolla,

Kamilya Kokabi

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(8), P. 3716 - 3716

Published: April 15, 2025

A significant challenge in cancer treatment is the rising problem of drug resistance that reduces effectiveness therapeutic strategies. Current knowledge shows multiple mechanisms play a role resistance. Another mechanism has gained attention alteration sphingolipid trafficking and dysregulation its metabolism, which was reported to cause cancer-associated Sphingolipids are lipids containing sphingosine have roles, ranging from lipid raft formation, apoptosis, cell signaling immune trafficking. Recent studies show developing cells, altered or dysregulated sphingolipids associated with efflux promote survival cells by bypassing apoptosis. Upregulated levels glucosylceramide synthase (GCS), an enzyme functions lead upregulated ABCB1 gene induces cells. These bypass make drugs induce apoptosis tumor ineffective. By highlighting current findings, this review aims provide caused synthase, kinase, acid ceramidase enzymes as possible targets enhance currently used chemotherapeutic agents.

Language: Английский

Citations

0
Research advances in traditional Chinese medicine formulae and active components targeting lipid metabolism for hepatocellular carcinoma therapy DOI Creative Commons
Liu Yang, Jie Yang,

YU Feng-hua

et al.

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: April 25, 2025

Hepatocellular carcinoma (HCC) has a relatively poor prognosis and high degree of malignancy. However, the therapeutic drugs are limited. In recent years, abnormal lipid metabolism its important role in HCC been reported, emerging studies found that some formulae active components traditional Chinese medicine (TCM) can regulate HCC, showing their good application prospects. Therefore, this article summarizes changes roles metabolites progression, discusses TCM for treatment based on regulation metabolism. A deeper understanding relationship may help precise use these HCC.

Language: Английский

Citations

0
The role of ACER2 in intestinal sphingolipid metabolism and gastrointestinal cancers DOI Creative Commons

Binggang Liu,

Zhou Junfeng,

Biao Jiang

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Nov. 22, 2024

Sphingolipids, particularly sphingosine-1-phosphate (S1P), are bioactive lipids involved in regulating cellular processes such as proliferation, apoptosis, inflammation, and tumor progression. Alkaline ceramidase 2 (ACER2) plays a critical role sphingolipid metabolism by catalyzing the hydrolysis of ceramide to sphingosine, which is subsequently converted S1P. Dysregulation ACER2 has been implicated various gastrointestinal cancers, including colorectal cancer, gastric hepatocellular carcinoma. ACER2-mediated signaling, through SphK/S1P pathway, influences cancer development modulating immune responses, balance between cell survival death. This review examines physiological functions ACER2, its metabolism, contribution pathogenesis cancers. Understanding mechanisms regulates progression modulation may open new avenues for targeted therapies malignancies.

Language: Английский

Citations

1
Unleashing the potential of Genistein and its derivatives as effective therapeutic agents for breast cancer treatment DOI
Eskandar Qaed, Wu Liu,

Marwan Almoiliqy

et al.

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 16, 2024

Language: Английский

Citations

0