A systematic review and meta-analysis on the transcriptomic signatures in alcohol use disorder DOI Creative Commons
Marion M. Friske,

Eva C Torrico,

Maximilian J W Haas

и другие.

Molecular Psychiatry, Год журнала: 2024, Номер unknown

Опубликована: Сен. 6, 2024

Язык: Английский

PCSK9 exacerbates sevoflurane-induced neuroinflammatory response and apoptosis by up-regulating cGAS-STING signal DOI Creative Commons
Tao Su, Y. Si

Tissue and Cell, Год журнала: 2025, Номер 93, С. 102739 - 102739

Опубликована: Янв. 14, 2025

Язык: Английский

Процитировано

0
Targeting Oxidative Stress in Neurodegenerative Disorders: A Novel Role for PCSK9 Inhibition? DOI
Lauren M. Park, Pál Pacher, Falk W. Lohoff

и другие.

ACS Chemical Neuroscience, Год журнала: 2024, Номер 15(15), С. 2662 - 2664

Опубликована: Июль 18, 2024

Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a protein that regulates cholesterol levels by lysosomal low-density lipoprotein receptor (LDLR) degradation and has recently been associated with the production of neuronal oxidative stress age-associated cardiovascular dysfunction. Since increased vascular dysfunction are implicated in pathology aging various neurodegenerative disorders, targeting PCSK9 may offer promising therapeutic avenue for addressing these conditions. While precise mechanisms through which contributes to brain remain elusive, preclinical studies have highlighted neuroprotective effect linked inhibition. This inhibition shown promise reducing stress, mitigating neuroinflammation, alleviating neuropathological changes, thus underscoring potential this approach

Язык: Английский

Процитировано

4
Biological age construction for prediction of mortality in the Chinese population DOI

Kaiyue Wang,

Xiang Gao, Ying Liu

и другие.

GeroScience, Год журнала: 2025, Номер unknown

Опубликована: Март 28, 2025

Язык: Английский

Процитировано

0
PCSK9 in Vascular Aging and Age-Related Diseases DOI Creative Commons

Dong Tan,

Xin Yang, Jing Yang

и другие.

Aging and Disease, Год журнала: 2025, Номер unknown, С. 0 - 0

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

0
Buyang Huanwu Decoction prevents hemorrhagic transformation after delayed t-PA infusion via inhibiting NLRP3 inflammasome/pyroptosis associated with microglial PGC-1α DOI

Ya‐Ru Pan,

Linlin Nie,

Weitao Chen

и другие.

Journal of Ethnopharmacology, Год журнала: 2024, Номер unknown, С. 119275 - 119275

Опубликована: Дек. 1, 2024

Язык: Английский

Процитировано

1
A systematic review and meta-analysis on the transcriptomic signatures in alcohol use disorder DOI Creative Commons
Marion M. Friske,

Eva C Torrico,

Maximilian J W Haas

и другие.

Molecular Psychiatry, Год журнала: 2024, Номер unknown

Опубликована: Сен. 6, 2024

Язык: Английский

Процитировано

0