A systematic review and meta-analysis on the transcriptomic signatures in alcohol use disorder DOI Creative Commons
Marion M. Friske,

Eva C Torrico,

Maximilian J W Haas

et al.

Molecular Psychiatry, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 6, 2024

Language: Английский

PCSK9 exacerbates sevoflurane-induced neuroinflammatory response and apoptosis by up-regulating cGAS-STING signal DOI Creative Commons
Tao Su, Y. Si

Tissue and Cell, Journal Year: 2025, Volume and Issue: 93, P. 102739 - 102739

Published: Jan. 14, 2025

Language: Английский

Citations

0
Targeting Oxidative Stress in Neurodegenerative Disorders: A Novel Role for PCSK9 Inhibition? DOI
Lauren M. Park, Pál Pacher, Falk W. Lohoff

et al.

ACS Chemical Neuroscience, Journal Year: 2024, Volume and Issue: 15(15), P. 2662 - 2664

Published: July 18, 2024

Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a protein that regulates cholesterol levels by lysosomal low-density lipoprotein receptor (LDLR) degradation and has recently been associated with the production of neuronal oxidative stress age-associated cardiovascular dysfunction. Since increased vascular dysfunction are implicated in pathology aging various neurodegenerative disorders, targeting PCSK9 may offer promising therapeutic avenue for addressing these conditions. While precise mechanisms through which contributes to brain remain elusive, preclinical studies have highlighted neuroprotective effect linked inhibition. This inhibition shown promise reducing stress, mitigating neuroinflammation, alleviating neuropathological changes, thus underscoring potential this approach

Language: Английский

Citations

4
Biological age construction for prediction of mortality in the Chinese population DOI

Kaiyue Wang,

Xiang Gao, Ying Liu

et al.

GeroScience, Journal Year: 2025, Volume and Issue: unknown

Published: March 28, 2025

Language: Английский

Citations

0
PCSK9 in Vascular Aging and Age-Related Diseases DOI Creative Commons

Dong Tan,

Xin Yang, Jing Yang

et al.

Aging and Disease, Journal Year: 2025, Volume and Issue: unknown, P. 0 - 0

Published: Jan. 1, 2025

Language: Английский

Citations

0
Buyang Huanwu Decoction prevents hemorrhagic transformation after delayed t-PA infusion via inhibiting NLRP3 inflammasome/pyroptosis associated with microglial PGC-1α DOI

Ya‐Ru Pan,

Linlin Nie,

Weitao Chen

et al.

Journal of Ethnopharmacology, Journal Year: 2024, Volume and Issue: unknown, P. 119275 - 119275

Published: Dec. 1, 2024

Language: Английский

Citations

1
A systematic review and meta-analysis on the transcriptomic signatures in alcohol use disorder DOI Creative Commons
Marion M. Friske,

Eva C Torrico,

Maximilian J W Haas

et al.

Molecular Psychiatry, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 6, 2024

Language: Английский

Citations

0