Cardiovascular Drugs and Therapy, Год журнала: 2023, Номер 38(5), С. 885 - 893
Опубликована: Июнь 8, 2023
To date, therapies for endothelial dysfunction have primarily focused on ameliorating identified atherosclerosis (AS) risk factors rather than explicitly addressing endothelium-based mechanism. An in-depth exploration of the pathological mechanisms injury was performed herein.
Язык: Английский
International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(20), С. 15200 - 15200
Опубликована: Окт. 15, 2023
Nitric oxide (NO) plays an important and diverse signalling role in the cardiovascular system, contributing to regulation of vascular tone, endothelial function, myocardial haemostasis, thrombosis, amongst many other roles. NO is synthesised through nitric synthase (NOS)-dependent L-arginine-NO pathway, as well nitrate-nitrite-NO pathway. The three isoforms NOS, namely neuronal (NOS1), inducible (NOS2), (NOS3), have different localisation functions human body, are consequently thought differing pathophysiological Furthermore, we continue develop a deepened understanding roles NOS disease, possibility therapeutically modulating activity has emerged. Indeed, impaired (or dysfunctional), overactive dysregulated) attractive therapeutic targets disease. This review aims describe recent advances elucidating physiological within mechanisms dysfunctional dysregulated We then discuss modulation target development novel therapeutics.
Язык: Английский
Процитировано
46
Biomaterials Research, Год журнала: 2023, Номер 27(1)
Опубликована: Фев. 9, 2023
Diabetic ulcers (DUs) are one of the most serious complications diabetes mellitus. The application a functional dressing is crucial step in DU treatment and associated with patient's recovery prognosis. However, traditional dressings simple structure single function cannot meet clinical requirements. Therefore, researchers have turned their attention to advanced polymer hydrogels solve therapeutic bottleneck treatment. Hydrogels class gels three-dimensional network that good moisturizing properties permeability promote autolytic debridement material exchange. Moreover, mimic natural environment extracellular matrix, providing suitable surroundings for cell proliferation. Thus, different mechanical strengths biological been extensively explored as platforms. In this review, we define types elaborate mechanisms by which they repair DUs. summarize pathological process DUs review various additives used Finally, examine limitations obstacles exist development clinically relevant applications these appealing technologies. This defines carefully diabetic (DUs), summarizes DUs, reviews bioactivators
Язык: Английский
Процитировано
31
Опубликована: Авг. 12, 2024
The triad of vascular impairment, muscle atrophy, and cognitive decline represents critical age-related conditions that significantly impact health. Vascular impairment disrupts blood flow, precipitating mass reduction seen in sarcopenia the neuronal functions characteristic neurodegeneration. Our limited understanding intricate relationships within this hinders accurate diagnosis effective treatment strategies. This review ana-lyzes interrelated mechanisms contribute to these conditions, with a specific focus on ox-idative stress, chronic inflammation, impaired nutrient delivery. aim is understand common pathways involved suggest comprehensive therapeutic approaches. dysfunctions hinder circulation transportation nutrients, resulting sar-copenia characterized by atrophy weakness. dysfunction have negative physical function quality life. Neurodegenerative diseases exhibit comparable pathophysiological affect motor functions. Preventive approaches encompass lifestyle adjustments, addressing oxidative in-flammation, integrated therapies improving muscular well-being. Better links can refine strategies yield better patient out-comes. study emphasizes complex interplay between dysfunction, de-generation, decline, highlighting necessity for multidisciplinary ap-proaches. Advances domain promise improved diagnostic accuracy, more thera-peutic options, enhanced preventive measures, all contributing higher life elderly population.
Язык: Английский
Процитировано
10
Frontiers in Pharmacology, Год журнала: 2024, Номер 15
Опубликована: Фев. 14, 2024
Shenfu injection (SFI), composed of ginseng and aconite, is a Chinese patent developed from the classic traditional prescription Decoction created more than 700 years ago. SFI has been widely used in China for over 30 treating cardiovascular diseases. The main components it include ginsenosides aconitum alkaloids. In recent years, role treatment diseases attracted much attention. pharmacological effects therapeutic applications are summarized here, highlighting features potential mechanisms developments, confirming that can play multiple ways promising drug
Язык: Английский
Процитировано
7
Biomedicines, Год журнала: 2024, Номер 12(9), С. 2096 - 2096
Опубликована: Сен. 13, 2024
The triad of vascular impairment, muscle atrophy, and cognitive decline represents critical age-related conditions that significantly impact health. Vascular impairment disrupts blood flow, precipitating the mass reduction seen in sarcopenia neuronal function characteristic neurodegeneration. Our limited understanding intricate relationships within this hinders accurate diagnosis effective treatment strategies. This review analyzes interrelated mechanisms contribute to these conditions, with a specific focus on oxidative stress, chronic inflammation, impaired nutrient delivery. aim is understand common pathways involved suggest comprehensive therapeutic approaches. dysfunctions hinder circulation transportation nutrients, resulting characterized by atrophy weakness. dysfunction have negative physical quality life. Neurodegenerative diseases exhibit comparable pathophysiological affect motor functions. Preventive approaches encompass lifestyle adjustments, addressing integrated therapies improving muscular well-being. Better links can refine strategies yield better patient outcomes. study emphasizes complex interplay between dysfunction, degeneration, decline, highlighting necessity for multidisciplinary Advances domain promise improved diagnostic accuracy, more options, enhanced preventive measures, all contributing higher life elderly population.
Язык: Английский
Процитировано
5
Frontiers in Endocrinology, Год журнала: 2023, Номер 14
Опубликована: Июнь 27, 2023
Vascular endothelial injury in diabetes mellitus (DM) is the major cause of vascular disease, which closely related to occurrence and development a series complications has serious negative impact on patient’s health quality life. The primary function normal endothelium as barrier function. However, presence DM, glucose lipid metabolism disorders, insulin resistance, inflammatory reactions, oxidative stress, other factors injury, leading lesions from morphology Recently, numerous studies have found that autophagy plays vital role regulating progression injury. Therefore, this article compares diabetic focuses current regulatory mechanisms important caused by different signal pathways. We aim provide some references for future research mechanism investigate autophagy’s protective or injurious effect, study potential drugs using target.
Язык: Английский
Процитировано
11
Journal of Adolescent Health, Год журнала: 2025, Номер unknown
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0
Frontiers in Endocrinology, Год журнала: 2024, Номер 15
Опубликована: Май 21, 2024
Hypertension, a multifaceted cardiovascular disorder influenced by genetic, epigenetic, and environmental factors, poses significant risk for the development of coronary artery disease (CAD) in individuals with type 2 diabetes mellitus (T2DM). Epigenetic alterations, particularly histone modifications, DNA methylation, microRNAs, play pivotal role unraveling complex molecular underpinnings blood pressure regulation. This review emphasizes crucial interplay between epigenetic attributes hypertension, shedding light on prominence both globally at gene-specific level, essential hypertension. Additionally, including acetylation emerge as markers linked to Furthermore, microRNAs exert regulatory influence homeostasis, targeting key genes within aldosterone renin-angiotensin pathways. Understanding intricate crosstalk genetics epigenetics hypertension is pertinent context its interaction T2DM, where serves notable factor CAD. These findings not only contribute comprehensive elucidation but also offer promising avenues innovative strategies prevention treatment complications, especially T2DM.
Язык: Английский
Процитировано
3
Burns & Trauma, Год журнала: 2023, Номер 11
Опубликована: Янв. 1, 2023
Multidrug-resistant (MDR) gram-negative bacteria-related infectious diseases have caused an increase in the public health burden and mortality. Moreover, formation of biofilms makes these bacteria difficult to control. Therefore, developing novel interventions combat MDR their biofilms-related infections are urgently needed. The purpose this study was develop a multifunctional nanoassembly (IRNB) based on IR-780 N, N'-di-sec-butyl-N, N'- dinitroso-1,4-phenylenediamine (BNN6) for synergistic effect infected wounds subcutaneous abscesses by bacteria. characterization bacteria-targeting ability IRNB were investigated. bactericidal efficacy against demonstrated crystal violet staining assay, plate counting method live/dead vitro. antibacterial efficiency examined abscess cutaneous wound model vivo. A cell kit-8 Calcein/PI cytotoxicity hemolysis assay intravenous injection performed detect biocompatibility vitro Herein, we successfully developed BNN6 photothermal therapy (PTT), photodynamic (PDT) nitric oxide (NO) triggered 808 nm laser. This could accumulate specifically at sites via covalent coupling effect. Upon irradiation with laser, activated produced both reactive oxygen species (ROS) hyperthermia. local hyperthermia induce NO generation, which further reacted ROS generate ONOO-, leading enhancement efficacy. Furthermore, ONOO- disrupt membrane, converts extremely susceptible state enhances In study, showed superior photothermal-photodynamic-chemo therapeutic resulted effective control associated infections, relief inflammation, promotion re-epithelization collagen deposition, regulation angiogenesis during healing. exhibited excellent biocompatibility, present research suggests that can be considered promising alternative treating biofilms.
Язык: Английский
Процитировано
8
Pharmacological Research - Natural Products, Год журнала: 2024, Номер 3, С. 100034 - 100034
Опубликована: Март 22, 2024
Язык: Английский
Процитировано
2