Biomaterials, Год журнала: 2022, Номер 287, С. 121656 - 121656
Опубликована: Июнь 28, 2022
Язык: Английский
Signal Transduction and Targeted Therapy, Год журнала: 2023, Номер 8(1)
Опубликована: Май 22, 2023
Abstract Macrophages exist in various tissues, several body cavities, and around mucosal surfaces are a vital part of the innate immune system for host defense against many pathogens cancers. possess binary M1/M2 macrophage polarization settings, which perform central role an array tasks via intrinsic signal cascades and, therefore, must be precisely regulated. Many crucial questions about signaling modulation yet to uncovered. In addition, clinical importance tumor-associated macrophages is becoming more widely recognized as significant progress has been made understanding their biology. Moreover, they integral tumor microenvironment, playing regulation wide variety processes including angiogenesis, extracellular matrix transformation, cancer cell proliferation, metastasis, immunosuppression, resistance chemotherapeutic checkpoint blockade immunotherapies. Herein, we discuss signaling, mechanical stresses modulation, metabolic pathways, mitochondrial transcriptional, epigenetic regulation. Furthermore, have broadly extended traps essential roles autophagy aging regulating functions. discussed recent advances macrophages-mediated autoimmune diseases tumorigenesis. Lastly, targeted therapy portray prospective targets therapeutic strategies health diseases.
Язык: Английский
Процитировано
750
Advanced Materials, Год журнала: 2022, Номер 34(35)
Опубликована: Апрель 26, 2022
Abstract Ischemic heart disease (IHD) is the leading cause of disability and mortality worldwide. Reactive oxygen species (ROS) have been shown to play key roles in progression diabetes, hypertension, hypercholesterolemia, which are independent risk factors that lead atherosclerosis development IHD. Engineered biomaterial‐based nanomedicines under extensive investigation exploration, serving as smart multifunctional nanocarriers for synergistic therapeutic effect. Capitalizing on cell/molecule‐targeting drug delivery, present enhanced specificity safety with favorable pharmacokinetics pharmacodynamics. Herein, ROS both IHD its discussed, highlighting cardiovascular medications antioxidant properties, summarizing advantages, recent achievements scavenging capacity treatment atherosclerosis, ischemia/reperfusion, myocardial infarction. Finally, current challenges ROS‐scavenging possible future directions discussed from a clinical perspective.
Язык: Английский
Процитировано
105
Bioactive Materials, Год журнала: 2022, Номер 22, С. 141 - 167
Опубликована: Сен. 29, 2022
Currently, there are no clinical drugs available to treat acute kidney injury (AKI). Given the high prevalence and mortality rate of AKI, development effectively AKI is a huge unmet medical need research hotspot. Although existing evidence fully demonstrates that reactive oxygen nitrogen species (RONS) burst at site major contributor progression, heterogeneity, complexity, unique physiological structure make most antioxidant anti-inflammatory small molecule ineffective because lack targeting side effects. Recently, nanodrugs with intrinsic through control size, shape, surface properties have opened exciting prospects for treatment AKI. Many emerged address limitations current treatments. In this review, we systematically summarized first time about emerging exploit pathological features overcome traditional small-molecule achieve efficacy. First, analyzed structural characteristics main mechanism AKI: hypoxia, harmful substance accumulation-induced RONS renal despite multifactorial initiation heterogeneity Subsequently, introduced strategies used improve reviewed advances nano-RONS-sacrificial agents, nanozymes, nanocarriers antioxidants drugs. These demonstrated excellent therapeutic effects, such as greatly reducing oxidative stress damage, restoring function, low Finally, discussed challenges future directions translating into treatment.
Язык: Английский
Процитировано
82
Chemical Engineering Journal, Год журнала: 2022, Номер 449, С. 137889 - 137889
Опубликована: Июль 4, 2022
Язык: Английский
Процитировано
71
ACS Nano, Год журнала: 2023, Номер 17(3), С. 2053 - 2066
Опубликована: Янв. 25, 2023
Injectable functional biomaterials have made significant progress in cardiac regenerative. In addition, how to adjust the abominable infarction microenvironment and introduce therapeutic stem cells improve healing effect has become a hotspot. Herein, injectable cell vector is prepared by combining natural alginate hydrogel Au@Pt nanoparticles (Au@Pt/Alg hydrogel) encapsulate brown adipose (BASCs). with both antioxidative conductive properties could effectively eliminate reactive oxygen species, enhance frequency of action potential release cardiomyocytes, further reduce inflammatory factors macrophage vitro. The Au@Pt/Alg enhances antioxidant, differentiation, paracrine capability BASCs. BASCs loaded evaluated rat myocardial (MI) model. anti-inflammatory, heart electrical integration are showed MI More interestingly, can maintain efficiency pro-angiogenesis effects infarcted area. This study led us recognize great value hydrogels for their ability actively regulate carry treatment.
Язык: Английский
Процитировано
56
Phytotherapy Research, Год журнала: 2023, Номер 37(4), С. 1590 - 1605
Опубликована: Фев. 8, 2023
Abstract Usually, in aerobic metabolism, natural materials including nucleic acids, proteins, and lipids can experience auxiliary injury by oxidative responses. This damage produced reactive oxygen/nitrogen species has been identified as “oxidative stress.” As a polyphenol got from red wine peanuts, resveratrol is one of the most eminent anti‐aging mixtures. Based on many studies', hinders destructive effects inflammatory causes oxygen radicals several tissues. The nuclear erythroid 2‐related factor 2 related to transcription with anti‐inflammatory, antioxidant possessions which complicated enzyme biotransformation biosynthesis carbohydrates. review provides current understanding information about character against stress regulation inflammation via Nrf2 signaling pathway.
Язык: Английский
Процитировано
55
Theranostics, Год журнала: 2023, Номер 13(8), С. 2721 - 2733
Опубликована: Янв. 1, 2023
Rationale: Myocardial injury triggers intense oxidative stress, inflammatory response, and cytokine release, which are essential for myocardial repair remodeling.Excess reactive oxygen species (ROS) scavenging inflammation elimination have long been considered to reverse injuries.However, the efficacy of traditional treatments (antioxidant, anti-inflammatory drugs natural enzymes) is still poor due their intrinsic defects such as unfavorable pharmacokinetics bioavailability, low biological stability, potential side effects.Nanozyme represents a candidate effectively modulate redox homeostasis treatment ROS related diseases.Methods: We develop an integrated bimetallic nanozyme derived from metal-organic framework (MOF) eliminate alleviate inflammation.The (Cu-TCPP-Mn) synthesized by embedding manganese copper into porphyrin followed sonication, could mimic cascade activities superoxide dismutase (SOD) catalase (CAT) transform radicals hydrogen peroxide, catalysis peroxide water.Enzyme kinetic analysis oxygen-production velocities were performed evaluate enzymatic Cu-TCPP-Mn.We also established infarction (MI) ischemia-reperfusion (I/R) animal models verify anti-inflammation effect Cu-TCPP-Mn.Results: As demonstrated analysis, Cu-TCPP-Mn possesses good performance in both SOD-and CAT-like achieve synergistic provide protection injury.In MI I/R models, this promising reliable technology protect heart tissue stress inflammation-induced injury, enables function recover otherwise severe damage.Conclusions: This research provides facile applicable method MOF nanozyme, alternative injuries.
Язык: Английский
Процитировано
55
Nano Letters, Год журнала: 2023, Номер 23(14), С. 6544 - 6552
Опубликована: Июль 4, 2023
As a ROS scavenger, resveratrol exerts neuroprotective effect by polarizing the M1 microglia to anti-inflammatory M2 phenotype for ischemic stroke treatment. However, obstruction of blood–brain barrier (BBB) seriously impairs efficacy resveratrol. Herein, we develop stepwise targeting nanoplatform enhanced therapy, which is fabricated pH-responsive poly(ethylene glycol)-acetal-polycaprolactone-poly(ethylene glycol) (PEG-Acetal-PCL-PEG) and modified with cRGD triphenylphosphine (TPP) on long PEG chain short chain, respectively. The as-designed micelle system features effective BBB penetration through cRGD-mediated transcytosis. Once entering brain tissues endocytosed microglia, shell can be detached from micelles in acidic lysosomes, subsequently exposing TPP target mitochondria. Thus, effectively alleviate oxidative stress inflammation delivery mitochondria, reversing scavenging ROS. This work offers promising strategy treat ischemia-reperfusion injury.
Язык: Английский
Процитировано
46
Advanced Materials, Год журнала: 2023, Номер 36(10)
Опубликована: Апрель 5, 2023
Metabolism is the sum of enzyme-dependent chemical reactions, which produces energy in catabolic process and synthesizes biomass anabolic process, exhibiting high similarity mammalian cell, microbial plant cell. Consequently, loss or gain metabolic enzyme activity greatly affects cellular metabolism. Nanozymes, as emerging mimics with diverse functions adjustable catalytic activities, have shown attractive potential for regulation. Although basic tasks are highly similar cells from different species, concrete pathway varies intracellular structure species. Here, metabolism living organisms described similarities differences pathways among mammalian, microbial, regulation mechanism discussed. The recent progress on mainly including nutrient uptake utilization, production, accompanied redox reactions by kinds oxidoreductases their applications field disease therapy, antimicrobial sustainable agriculture systematically reviewed. Furthermore, prospects challenges nanozymes regulating cell also discussed, broaden application scenarios.
Язык: Английский
Процитировано
45
Pharmacological Research, Год журнала: 2023, Номер 199, С. 106957 - 106957
Опубликована: Окт. 10, 2023
SIRT1 is a highly conserved nicotinamide adenine dinucleotide (NAD
Язык: Английский
Процитировано
44