Nanozyme-Engineered Hydrogels for Anti-Inflammation and Skin Regeneration

Nano-Micro Letters, Год журнала: 2024, Номер 16(1)

Опубликована: Фев. 6, 2024

Inflammatory skin disorders can cause chronic scarring and functional impairments, posing a significant burden on patients the healthcare system. Conventional therapies, such as corticosteroids nonsteroidal anti-inflammatory drugs, are limited in efficacy associated with adverse effects. Recently, nanozyme (NZ)-based hydrogels have shown great promise addressing these challenges. NZ-based possess unique therapeutic abilities by combining benefits of redox nanomaterials enzymatic activity water-retaining capacity hydrogels. The multifaceted effects include scavenging reactive oxygen species other inflammatory mediators modulating immune responses toward pro-regenerative environment enhancing regenerative potential triggering cell migration differentiation. This review highlights current state art NZ-engineered (NZ@hydrogels) for regeneration applications. It also discusses underlying chemo-mechano-biological mechanisms behind their effectiveness. Additionally, challenges future directions this ground, particularly clinical translation, addressed. insights provided aid design engineering novel hydrogels, offering new possibilities targeted personalized skin-care therapies.

Язык: Английский

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Bioorthogonal Cu Single‐atom Nanozyme for Synergistic Nanocatalytic Therapy, Photothermal Therapy, Cuproptosis, and Immunotherapy

Angewandte Chemie International Edition, Год журнала: 2024, Номер 63(27)

Опубликована: Апрель 24, 2024

Single-atom nanozymes (SAzymes) with atomically dispersed active sites are potential substitutes for natural enzymes. A systematic study of its multiple functions can in-depth understand SAzymes's nature, which remains elusive. Here, we develop a novel ultrafast synthesis sputtered SAzymes by in situ bombarding-embedding technique. Using this method, copper (Cu) (CuSA) is developed unreported unique planar Cu-C

Язык: Английский

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2D Catalytic Nanozyme Enables Cascade Enzyodynamic Effect‐Boosted and Ca²⁺ Overload‐Induced Synergistic Ferroptosis/Apoptosis in Tumor

Advanced Materials, Год журнала: 2024, Номер 36(24)

Опубликована: Март 19, 2024

Abstract The introduction of glucose oxidase, exhibiting characteristics consumption and H 2 O production, represents an emerging antineoplastic therapeutic approach that disrupts nutrient supply promotes efficient generation reactive oxygen species (ROS). However, the instability natural enzymes their low efficacy significantly impede broader application. In this context, 2D Ca Mn 8 16 nanosheets (CMO NSs) designed engineered to serve as a high‐performance nanozyme, enhancing enzyodynamic effect for ferroptosis–apoptosis synergistic tumor therapy, are presented. addition mimicking activities glutathione peroxidase, catalase, CMO NSs exhibit oxidase‐mimicking activities. This feature contributes antitumor performance through cascade catalytic reactions, involving disruption supply, self‐supply , subsequent ROS generation. exogenous 2+ released from NSs, along with endogenous enrichment induced by peroxidase‐ collectively mediate overload, leading apoptosis. Importantly, ferroptosis process is triggered synchronously output consumption. application ultrasound stimulation further enhances efficiency treatment. work underscores crucial role in therapy against tumors.

Язык: Английский

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Stabilizer-free MnO2 nanozyme with singlet-oxygen conducted high oxidase-like activity and fast catalysis capability for improving alkaline phosphatase assay

Sensors and Actuators B Chemical, Год журнала: 2024, Номер 404, С. 135280 - 135280

Опубликована: Янв. 13, 2024

Язык: Английский

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Biomedical applications of cerium vanadate nanoparticles: a review

Journal of Materials Chemistry B, Год журнала: 2023, Номер 12(3), С. 609 - 636

Опубликована: Дек. 11, 2023

Cerium vanadate nanoparticles (CeVO

Язык: Английский

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Cerium dioxide nanozyme doped hybrid hydrogel with antioxidant and antibacterial abilities for promoting diabetic wound healing

Chemical Engineering Journal, Год журнала: 2024, Номер 497, С. 154517 - 154517

Опубликована: Авг. 3, 2024

Язык: Английский

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Multifunctional nanozymes for disease diagnosis and therapy

Biomedical Journal, Год журнала: 2024, Номер 47(4), С. 100699 - 100699

Опубликована: Янв. 24, 2024

The development of nanotechnology has brought about groundbreaking advancements in diseases' diagnostics and therapeutics. Among them, multifunctional nanomaterials with enzyme-like activities (i.e., nanozymes) featured high stability, large surface area for bioconjugation, easy storage, offer unprecedented opportunities disease treatment. Recent years have witnessed the great progress nanozyme-based theranostics. To highlight these achievements, this review first introduces recent on nanozymes biosensing diagnostics. Then, it summarizes applications therapeutics including anti-tumor antibacterial treatment, anti-inflammatory other diseases In addition, several targeted strategies to improve therapeutic efficacy nanozyme are discussed. Finally, challenges field diagnosis therapy summarized.

Язык: Английский

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Bioactive Decellularized Extracellular Matrix Platform Integrating Multifunctional Nanozymes and Cell-Laden Microgels for Acute Liver Failure Treatment

ACS Nano, Год журнала: 2025, Номер unknown

Опубликована: Фев. 14, 2025

Mesenchymal stem cell (MSC) therapy has emerged as a promising alternative approach for treating acute liver failure (ALF) while confronting the shortage of low efficiency and poor engraftment within hostile milieu. In this study, we establish bioactive decellularized extracellular matrix (dECM) platform that incorporates dihydrolipoic acid (DHLA)-protected Pt nanoclusters doped with Cu (PtCu-DHLA) nanozymes cell-laden microgels. The PtCu-DHLA nanozymes, selected their versatility, function antioxidant, anti-inflammatory, pro-proliferative, pro-angiogenic agents, enhancing ALF alleviation providing an optimal microenvironment MSC transplantation. Additionally, methacrylic anhydride (MA)-modified porcine liver-derived (PLdECM) hydrogel (PLdECMMA) been developed construction microgels via microfluidic devices. Interferon γ (IFNγ) preconditioned MSCs encapsulated in PLdECMMA exhibit enhanced immunomodulating activity prolonged survival. are codelivered by leveraging PLdECM orthotopic transplanted dECM enables efficient successful rescue CCl4-induced counteracting oxidative stress, suppressing inflammatory storms, promoting cellular regeneration. Overall, study highlights synergistic reinforced strategy combines biomimetic therapy, offering significant potential treatment broader applications regenerative medicine.

Язык: Английский

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A Versatile Nanozyme‐Based NADH Circulating Oxidation Reactor for Tumor Therapy through Triple Cellular Metabolism Disruption

Small, Год журнала: 2024, Номер 20(26)

Опубликована: Янв. 23, 2024

Nanozyme-based metabolic regulation triggered by tumor-specific endogenous stimuli has emerged as a promising therapeutic strategy for tumors. The current efficacy, however, is constrained the limited concentration of substrates and plasticity Consequently, implementation efficient in tumor therapy urgently needed. Herein, versatile nanozyme-based nicotinamide adenine dinucleotide (NADH) circulating oxidation nanoreactor reported. First, synthesized cobalt-doped hollow carbon spheres (Co-HCS) possess NADH oxidase (NOX)-mimicking activity to disrupt oxidative phosphorylation (OXPHOS) pathway cells. Second, substrate-cycle manner Co-HCS can be used overcome limitation substrate deficiency. Finally, 2-Deoxy-D-glucose (2-DG) 6-aminonicotinamide (6-AN) are introduced block glycolysis pentose phosphate (PPP), thus creating (Co-HCS/D/A) through triple cellular metabolism disruption. In vitro vivo results demonstrate that designed not only enhances catalytic efficiency but also disrupts homeostasis, leading outcome. This study develops novel disruption, which addresses limitations therapy.

Язык: Английский

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Bioorthogonal Cu Single‐Atom Nanozyme for Synergistic Nanocatalytic Therapy, Photothermal Therapy, Cuproptosis and Immunotherapy

Angewandte Chemie, Год журнала: 2024, Номер 136(27)

Опубликована: Апрель 24, 2024

Abstract Single‐atom nanozymes (SAzymes) with atomically dispersed active sites are potential substitutes for natural enzymes. A systematic study of its multiple functions can in‐depth understand SAzymes's nature, which remains elusive. Here, we develop a novel ultrafast synthesis sputtered SAzymes by in situ bombarding‐embedding technique. Using this method, copper (Cu) (CuSA) is developed unreported unique planar Cu‐C 3 coordinated configuration. To enhance the tumor‐specific targeting, employ bioorthogonal approach to engineer CuSA, denoted as CuSACO. CuSACO not only exhibits minimal off‐target toxicity but also possesses exceptional ultrahigh catalase‐, oxidase‐, peroxidase‐like multienzyme activities, resulting reactive oxygen species (ROS) storm generation effective tumor destruction. Surprisingly, release Cu ions presence glutathione (GSH) induce cuproptosis, enhancing treatment efficacy. Notably, CuSACO′s remarkable photothermal properties enables precise therapy (PTT) on tumors. This, combined nanozyme catalytic cuproptosis and immunotherapy, efficiently inhibiting growth orthotopic breast tumors gliomas, lung metastasis. Our research highlights an innovative strategy utilize mechanism therapeutic efficacy, broadening exploration development enzyme‐like behavior physiological action SAzymes.

Язык: Английский

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