Poultry Science,
Год журнала:
2023,
Номер
103(1), С. 103218 - 103218
Опубликована: Окт. 20, 2023
Heat
stress
(HS)
is
still
the
essential
environmental
agent
influencing
poultry
industry.
Research
on
HS
in
has
progressively
acquired
growing
interest
because
of
increased
attention
to
climate
alteration.
Poultry
can
survive
at
certain
zone
temperatures,
so
it
could
be
considered
homoeothermic.
In
poultry,
normal
body
temperature
enhance
internal
environment
for
growth,
which
achieved
by
temperature.
Recently,
many
studies
have
revealed
that
cause
mitochondrial
dysfunction
broilers
inducing
redox
dysfunction,
increasing
uncoupling
protein,
boosting
lipid
and
protein
oxidation,
oxidative
stress.
Moreover,
diminished
energy
suppliers
supported
mitochondria
activity.
A
novel
strategy
combating
negative
influences
via
function
through
enrichment
diets
with
enhancers
was
also
described
this
review.
Finally,
current
review
highlights
induced
attempts
boost
functionality
enriching
broiler
diets.
Cells,
Год журнала:
2023,
Номер
12(11), С. 1545 - 1545
Опубликована: Июнь 4, 2023
Placentation
is
a
key
and
tightly
regulated
process
that
ensures
the
normal
development
of
placenta
fetal
growth.
Preeclampsia
(PE)
hypertensive
pregnancy-related
disorder
involving
about
5–8%
all
pregnancies
clinically
characterized
by
de
novo
maternal
hypertension
proteinuria.
In
addition,
PE
are
also
increased
oxidative
stress
inflammation.
The
NRF2/KEAP1
signaling
pathway
plays
an
important
role
in
protecting
cells
against
damage
due
to
reactive
oxygen
species
(ROS)
levels.
ROS
activate
NRF2,
allowing
its
binding
antioxidant
response
element
(ARE)
region
present
promoter
several
genes
such
as
heme
oxygenase,
catalase,
glutathione
peroxidase
superoxide
dismutase
neutralize
ROS,
damages.
this
review,
we
analyze
current
literature
regarding
preeclamptic
pregnancies,
discussing
main
cellular
modulators
pathway.
Moreover,
discuss
natural
synthetic
compounds
can
regulate
vivo
vitro
models.
Scientific Reports,
Год журнала:
2024,
Номер
14(1)
Опубликована: Март 4, 2024
Abstract
Arterial
occlusion-induced
ischemic
stroke
(IS)
is
a
highly
frequent
subtype.
Nuclear
factor
erythroid
2-related
2
(NRF2)
transcription
that
modulates
antioxidant
genes.
Its
role
in
IS
still
unelucidated.
The
current
study
focused
on
constructing
transient
middle
cerebral
artery
occlusion
(tMCAO)
model
for
investigating
the
NRF2-related
mechanism
underlying
ischemia/reperfusion
(I/R)
injury.
Each
male
C57BL/6
mouse
was
injected
with/with
no
specific
NRF2
activator
post-tMCAO.
Changes
blood–brain
barrier
(BBB)-associated
molecule
levels
were
analyzed
using
western-blotting,
PCR,
immunohistochemistry,
and
immunofluorescence
analysis.
within
I/R
decreased
at
24-h
post-ischemia.
activation
improved
brain
edema,
infarct
volume,
neurological
deficits
after
MCAO/R.
Similarly,
sulforaphane
(SFN)
prevented
down-regulated
tight
junction
proteins
occludin
zonula
occludens
1
(ZO-1)
reduced
up-regulated
aquaporin
4
(AQP4)
matrix
metalloproteinase
9
(MMP9)
tMCAO.
Collectively,
exerted
critical
effect
preserving
BBB
integrity
modulating
ferroptosis
inflammation.
Because
related
to
injury
regulation
following
I/R,
this
provides
potential
therapeutic
target
throws
light
clinically
treating
IS.
Current Research in Food Science,
Год журнала:
2025,
Номер
10, С. 100972 - 100972
Опубликована: Янв. 1, 2025
Resveratrol
(RES),
a
natural
polyphenolic
compound,
has
shown
promise
in
enhancing
skeletal
muscle
regeneration
and
metabolic
function.
This
study
aims
to
explore
the
impact
of
RES
on
after
injury
through
regulation
antioxidant
capacity
mitochondrial
biogenesis.
treatment
significantly
increased
ratio
tibialis
anterior
mass
body
weight,
alongside
reduced
fasting
glucose
levels.
Following
cardiotoxin-induced
injury,
improved
regeneration,
characterized
by
greater
formation
new
fibers
better
structural
repair
compared
control.
Notably,
gene
expression
analyses
demonstrated
that
RES-treated
mice
exhibited
elevated
levels
myogenic
markers,
such
as
paired
box
7
(Pax7),
factor
5
(Myf5),
myoblast
determination
protein
(MyoD),
Myogenin
(MyoG).
Concurrently,
yes-associated
(YAP)
increased,
underscoring
its
role
regulating
satellite
cell
activity.
Transcriptomic
analysis
identified
enriched
pathways
related
biogenesis,
with
transcription
factors
higher
DNA
content
mice.
Furthermore,
enhanced
via
Kelch-like
ECH-associated
1
(KEAP-1)/nuclear
erythroid
2-related
2
(NRF2)/heme
oxygenase-1
(HO-1)
signaling
pathway,
indicated
activities
total
capacity,
Glutathione
peroxidase
(GSH-PX),
superoxidase
dismutase
(SOD).
Collectively,
these
findings
suggest
not
only
promotes
but
also
supports
function
defenses,
positioning
it
food-derived
pharmaceutical
for
targeting
injury.
Frontiers in Pharmacology,
Год журнала:
2025,
Номер
15
Опубликована: Янв. 13, 2025
Resveratrol,
a
polyphenolic
compound
known
for
its
diverse
biological
activities,
has
demonstrated
multiple
pharmacological
effects,
including
anti-inflammatory,
anti-aging,
anti-diabetic,
anti-cancer,
and
cardiovascular
protective
properties.
Recent
studies
suggest
that
these
effects
are
partly
mediated
through
the
regulation
of
macrophage
polarization,
wherein
macrophages
differentiate
into
pro-inflammatory
M1
or
anti-inflammatory
M2
phenotypes.
Our
review
highlights
how
resveratrol
modulates
polarization
various
signaling
pathways
to
achieve
therapeutic
effects.
For
example,
can
activate
senescence-associated
secretory
phenotype
(SASP)
pathway
inhibit
signal
transducer
activator
transcription
(STAT3)
sphingosine-1-phosphate
(S1P)-YAP
axes,
promoting
suppressing
thereby
inhibiting
tumor
growth.
Conversely,
it
promote
suppress
by
NF-κB
activating
PI3K/Akt
AMP-activated
protein
kinase
(AMPK)
pathways,
thus
alleviating
inflammatory
responses.
Notably,
effect
on
is
concentration-dependent;
moderate
concentrations
tend
while
higher
may
favor
polarization.
This
concentration
dependence
offers
new
perspectives
clinical
treatment
but
also
underscores
necessity
precise
dosage
control
when
using
resveratrol.
In
summary,
exhibits
significant
potential
in
regulating
treating
related
diseases.
Environmental Toxicology,
Год журнала:
2023,
Номер
39(4), С. 2052 - 2063
Опубликована: Дек. 14, 2023
Abstract
Imidacloprid
(IMI)
is
a
neonicotinoid
insecticide
with
the
highest
global
market
share,
and
IMI
exposure
in
environment
can
negatively
affect
many
nontarget
organisms
(a
general
term
for
affected
by
drugs
other
than
target
organisms).
Resveratrol
(RSV),
non‐flavonoid
polyphenolic
organic
compound
derived
from
peanuts,
grapes,
plants,
has
anti‐inflammatory
antioxidant
effects.
It
currently
unclear
how
RSV
protects
against
cell
damage
caused
IMI.
Therefore,
we
established
an
experimental
model
of
chicken
lymphocyte
lines
exposed
to
110
μg/mL
and/or
0.5
μM
24
h.
According
results,
markedly
raised
intracellular
reactive
oxygen
species
levels
diminished
activity
cellular
enzymes
(CAT,
SOD,
GPx),
leading
MDA
accumulation
decreased
T‐AOC.
JNK
,
ERK
P38
essential
components
mitogen‐activated
protein
kinase
(MAPK)
signaling
pathway,
were
also
expressed
more
when
was
present.
Additionally,
resulted
upregulation
mitochondrial
apoptosis
(
Caspase
3
9
Bax
Cyt‐c
)
necroptosis
8
RIPK1
RIPK3
MLKL
related
factors
expression,
downregulation
Bcl‐2
induction
cytokine
IL‐6
TNF‐α
IFN‐γ
expression.
The
combined
treatment
significantly
reduced
oxidative
stress
levels,
inhibited
MAPK
alleviated
IMI‐induced
apoptosis,
necroptosis,
immune
dysfunction.
To
summarize,
antagonized
dysfunction
inhibiting
ROS/MAPK
pathway.
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(5), С. 2671 - 2671
Опубликована: Фев. 25, 2024
The
prevalence
and
incidence
of
obesity
the
comorbidities
linked
to
it
are
increasing
worldwide.
Current
therapies
for
associated
pathologies
have
proven
cause
a
broad
number
adverse
effects,
often,
they
overpriced
or
not
affordable
all
patients.
Among
alternatives
currently
available,
natural
bioactive
compounds
stand
out.
These
frequently
contained
in
pharmaceutical
presentations,
nutraceutical
products,
supplements,
functional
foods.
clinical
evidence
these
molecules
is
increasingly
solid,
among
which
epigallocatechin-3-gallate,
ellagic
acid,
resveratrol,
berberine,
anthocyanins,
probiotics,
carotenoids,
curcumin,
silymarin,
hydroxy
citric
α-lipoic
acid
molecular
mechanisms
signaling
pathways
been
shown
interact
with
endocrine,
nervous,
gastroenteric
systems.
They
can
regulate
expression
multiple
genes
proteins
involved
starvation–satiety
processes,
activate
brown
adipose
tissue,
decrease
lipogenesis
inflammation,
increase
lipolysis,
improve
insulin
sensitivity.
This
review
provides
comprehensive
view
nature-based
therapeutic
options
address
obesity.
It
offers
valuable
perspective
future
research
subsequent
practice,
addressing
everything
from
molecular,
genetic,
physiological
bases
study
compounds.
Stroke
is
a
cerebrovascular
disease
that
the
main
cause
of
death
and
disability
worldwide.
Hypoxia
major
factor
causes
neuronal
damage
even
cellular
death.
However,
mechanism
therapeutic
drugs
for
hypoxia
are
not
completely
understood.
In
this
study,
PC12
cells
(a
rat
adrenal
pheochromocytoma
cell
line)
were
exposed
to
Cobalt
chloride
(CoCl2)
induce
hypoxia.
Using
model,
impacts
on
viability,
proliferation,
reactive
oxygen
species
(ROS),
levels
lysine
β-hydroxybutyrylation
(Kbhb)
inflammatory
signaling
P65
examined.
addition,
we
explored
ability
resveratrol
(RES)
alleviate
CoCl2-induced
damage.
RES
attenuated
decreases
viability
proliferation
increase
ROS
production
in
cells.
CoCl2
downregulated
Kbhb
cells,
but
alleviated
effect.
upregulated
by
3-hydroxybutyric
acid
sodium
could
partially
recover
including
oxidative
stress,
protein
level
P65.
Our
results
indicate
protects
against
modulating
Kbhb,
novel
post-translational
modification.
Frontiers in Immunology,
Год журнала:
2023,
Номер
14
Опубликована: Окт. 23, 2023
Osteoporosis
is
a
common
metabolic
disease
in
middle-aged
and
elderly
people.
It
characterized
by
reduction
bone
mass,
compromised
microstructure,
heightened
fragility,
an
increased
susceptibility
to
fractures.
The
dynamic
imbalance
between
osteoblast
osteoclast
populations
decisive
factor
the
occurrence
of
osteoporosis.
With
increase
population
society,
incidence
osteoporosis,
disability,
mortality
have
gradually
increased.
Polyphenols
are
fascinating
class
compounds
that
found
both
food
medicine
exhibit
variety
biological
activities
with
significant
health
benefits.
As
component
food,
polyphenols
not
only
provide
color,
flavor,
aroma
but
also
act
as
potent
antioxidants,
protecting
our
cells
from
oxidative
stress
reducing
risk
chronic
disease.
Moreover,
these
natural
anti-inflammatory
properties,
which
aid
immune
response
regulation
potentially
alleviate
symptoms
diverse
ailments.
gut
microbiota
can
degrade
into
more
absorbable
metabolites,
thereby
increasing
their
bioavailability.
shape
its
abundance.
Therefore,
studying
synergistic
effect
may
help
treatment
prevention
By
delving
how
enhance
bioavailability
abundance,
this
review
offers
valuable
information
references
for
