ACS Applied Materials & Interfaces,
Год журнала:
2024,
Номер
16(27), С. 34720 - 34731
Опубликована: Июнь 27, 2024
Anti-inflammatory
and
angiogenesis
are
two
important
factors
in
wound
healing.
Wound
dressings
with
anti-inflammation
vascularization
essential
to
address
complex
interventions,
expensive
treatments,
uncontrolled
release
mechanisms.
Based
on
the
above
considerations,
we
designed
a
near-infrared
(NIR)-responsive
hydrogel
dressing,
which
is
composed
of
mPDA-DFO@LA
nanoparticles
(mPDA:
dopamine
hydrochloride
nanoparticles,
DFO:
deferoxamine,
LA:
lauric
acid),
valsartan
(abbreviated
as
Va),
dopamine–hyaluronic
acid
hydrogel.
The
dressing
demonstrated
injectability,
bioadhesive,
photothermal
properties.
results
indicated
obtained
by
releasing
Va
can
appropriately
regulate
macrophage
phenotype
transformation
from
M1
M2,
resulting
an
anti-inflammatory
environment.
In
addition,
DFO
encapsulated
LA
be
sustainably
released
into
site
NIR
irradiation,
further
prevents
excessive
neovascularization.
Notably,
vivo
mPDA-DFO@LA/Va
significantly
enhanced
recovery,
achieving
healing
rate
up
96%
after
11
days
treatment.
Therefore,
this
NIR-responsive
anti-inflammation,
vascularization,
on-demand
programmed
drug
will
promising
for
infection.
A
prominent
research
topic
in
contemporary
advanced
functional
materials
science
is
the
production
of
smart
based
on
polymers
that
may
independently
adjust
their
physical
and/or
chemical
characteristics
when
subjected
to
external
stimuli.
Smart
hydrogels
poly(N-isopropylacrylamide)
(PNIPAM)
demonstrate
distinct
thermoresponsive
features
close
a
lower
critical
solution
temperature
(LCST)
enhance
capability
various
biomedical
applications
such
as
drug
delivery,
tissue
engineering,
and
wound
dressings.
Nevertheless,
they
have
intrinsic
shortcomings
poor
mechanical
properties,
limited
loading
capacity
actives,
biodegradability.
Formulation
PNIPAM
with
diverse
constituents
develop
hydrogel
composites
an
efficient
scheme
overcome
these
defects,
which
can
significantly
help
for
practicable
application.
This
review
reports
latest
developments
PNIPAM-based
applications.
The
first
section
describes
properties
hydrogels,
followed
by
potential
fields.
Ultimately,
this
summarizes
challenges
opportunities
emerging
area
development
concerning
fascinating
polymer-based
system
deep-rooted
chemistry
material
science.
Materials Today Bio,
Год журнала:
2022,
Номер
18, С. 100508 - 100508
Опубликована: Ноя. 30, 2022
Poor
wound
healing
after
diabetes
mellitus
remains
a
challenging
problem,
and
its
pathophysiological
mechanisms
have
not
yet
been
fully
elucidated.
Persistent
bleeding,
disturbed
regulation
of
inflammation,
blocked
cell
proliferation,
susceptible
infection
impaired
tissue
remodeling
are
the
main
features
diabetic
healing.
Conventional
dressings,
including
gauze,
films
bandages,
limited
function.
They
generally
act
as
physical
barriers
absorbers
exudates,
which
fail
to
meet
requirements
whol
process.
Wounds
in
patients
typically
heal
slowly
due
hyperglycemia
within
bed.
Once
bacterial
cells
develop
into
biofilms,
wounds
will
exhibit
robust
drug
resistance.
Recently,
application
stimuli-responsive
hydrogels,
also
known
"smart
hydrogels",
for
has
attracted
particular
attention.
The
basic
feature
this
system
is
capacities
change
mechanical
properties,
swelling
ability,
hydrophilicity,
permeability
biologically
active
molecules,
etc.,
response
various
stimuli,
temperature,
potential
hydrogen
(pH),
protease
other
biological
factors.
Smart
hydrogels
can
improve
therapeutic
efficacy
limit
total
toxicity
according
characteristics
wounds.
In
review,
we
summarized
mechanism
It
hoped
that
work
provide
some
inspiration
suggestions
research
field.
Advanced Healthcare Materials,
Год журнала:
2023,
Номер
13(1)
Опубликована: Сен. 13, 2023
Abstract
The
healing
of
diabetic
wounds
is
hindered
by
various
factors,
including
bacterial
infection,
macrophage
dysfunction,
excess
proinflammatory
cytokines,
high
levels
reactive
oxygen
species,
and
sustained
hypoxia.
These
factors
collectively
impede
cellular
behaviors
the
process.
Consequently,
this
review
presents
intelligent
hydrogels
equipped
with
multifunctional
capacities,
which
enable
them
to
dynamically
respond
microenvironment
accelerate
wound
in
ways,
stimuli
‐responsiveness,
injectable
self‐healing,
shape
‐memory,
conductive
real‐time
monitoring
properties.
relationship
between
multiple
functions
also
discussed.
Based
on
wounds,
antibacterial,
anti‐inflammatory,
immunomodulatory,
antioxidant,
pro‐angiogenic
strategies
are
combined
hydrogels.
application
repair
systematically
discussed,
aiming
provide
guidelines
for
fabricating
exploring
role
therapeutic
processes.
Abstract
Due
to
global
aging
problems,
the
rising
number
of
patients
suffering
from
chronic
or
hard‐to‐heal
acute
wounds
imposes
a
significant
burden
on
healthcare
systems.
Wound
healing
is
complicated
and
dynamic
physiological
process
with
distinct
molecular
cellular
levels
at
each
phase.
Despite
numerous
strategies
advanced
wound
dressings
being
developed,
successful
management
through
smart
dressing
materials
that
can
adapt
changing
microenvironments
address
needs
different
stages
remains
big
challenge.
Over
last
decade,
hydrogel‐based
have
emerged
as
one
most
potent
biomaterials
for
treatment
favorable
biological
characteristics
high
potential
active
intervention
during
wound‐curing
process.
In
current
contribution,
we
present
recent
progress
in
hydrogel
regulate
release
therapeutics
response
external
stimuli
(such
light)
well
endogenous
changes
environments
(e.g.,
temperature,
pH,
glucose,
reactive
oxygen
species)
facilitate
healing.
We
also
introduce
cutting‐edge
technologies
intelligent
“sense‐and‐treat”
combination
built‐in
sensors
sensing
molecules
responsive
hydrogels,
which
enable
real‐time
monitoring
conditions
prompt
on‐demand
therapy.
ACS Nano,
Год журнала:
2023,
Номер
17(2), С. 1393 - 1402
Опубликована: Янв. 9, 2023
Among
the
increasingly
popular
miniature
and
flexible
smart
electronics,
two-dimensional
materials
show
great
potential
in
development
of
electronics
owing
to
their
layered
structures
outstanding
electrical
properties.
MXenes
have
attracted
much
attention
excellent
hydrophilicity
metallic
conductivity.
However,
limited
interlayer
spacing
tendency
for
self-stacking
lead
changes
electron
channels
under
external
pressure,
making
it
difficult
exploit
surface
metal
We
propose
a
strategy
rapid
gas
foaming
construct
tunable
MXene
aerogels.
aerogels
with
rich
network
generate
maximized
facilitating
effective
utilization
properties
MXene;
this
forms
self-healable
pressure
sensor
sensing
such
as
high
sensitivity
(1,799.5
kPa–1),
fast
response
time
(11
ms),
good
cycling
stability
(>25,000
cycles).
This
has
applications
human
body
detection,
human–computer
interaction,
self-healing,
remote
monitoring,
distribution
identification.
The
channel
design
provides
simple,
efficient,
scalable
method
effectively
conduction
2D
materials.
ACS Materials Letters,
Год журнала:
2023,
Номер
5(7), С. 1787 - 1830
Опубликована: Май 26, 2023
Due
to
the
good
reliability
and
long-term
stability,
self-healing
hydrogels
have
emerged
as
promising
soft
materials
for
tissue
engineering,
smart
wearable
sensors,
bioelectronics,
energy
storage
devices.
The
mechanism
depends
on
reversible
chemical
or
physical
cross-linking
interactions.
Self-healing
with
fascinating
features
(including
mechanical
performances,
biocompatibility,
conductivity,
antibacterial
ability,
responsiveness,
etc.)
are
being
designed
developed
according
practical
application
requirements.
In
this
review,
recent
progress
in
their
synthesis
strategies
multiple
applications
is
summarized.
Their
involve
processes
a
combination
of
two.
include
flexible
strain
supercapacitors,
actuators,
adhesives,
wound
healing,
drug
delivery,
tumor
treatment,
3D
printing,
etc.
Finally,
current
challenges,
future
development,
opportunities
discussed.
Bioactive Materials,
Год журнала:
2023,
Номер
32, С. 66 - 97
Опубликована: Сен. 29, 2023
Ferroptosis
offers
a
novel
method
for
overcoming
therapeutic
resistance
of
cancers
to
conventional
cancer
treatment
regimens.
Its
effective
use
as
therapy
requires
precisely
targeted
approach,
which
can
be
facilitated
by
using
nanoparticles
and
nanomedicine,
their
enhance
ferroptosis
is
indeed
growing
area
research.
While
few
review
papers
have
been
published
on
iron-dependent
mechanism
inducers
that
partly
covers
nanoparticles,
there
need
comprehensive
focusing
the
design
magnetic
typically
supply
iron
ions
promote
simultaneously
enable
nanomedicine.
Furthermore,
locally
induce
combinational
with
diagnostic
resonance
imaging
(MRI).
The
remotely
controllable
nanocarriers
offer
highly
localized
image-guided
Here,
recent
developments
in
magnetically
manipulable
nanomedicine
medical
are
summarized.
This
also
highlights
advantages
current
state-of-the-art
Finally,
image
guided
apoptosis-based
enables
synergistic
tumor
discussed
clinical
translations.
ACS Applied Materials & Interfaces,
Год журнала:
2023,
Номер
15(6), С. 7725 - 7734
Опубликована: Фев. 2, 2023
Oxygen
plays
an
important
role
in
diabetic
chronic
wound
healing
by
regulating
various
life
activities
such
as
cell
proliferation,
migration,
and
angiogenesis.
Therefore,
oxygen-delivering
systems
have
drawn
much
attention
evolved
continuously.
Here,
we
propose
that
active
Chlorella
vulgaris
(Cv)-loaded
separable
microneedle
(MN)
can
be
used
to
control
oxygen
delivery,
which
then
promotes
healing.
The
Cv-loaded
microneedles
(CvMN)
consist
of
a
polyvinyl
acetate
(PVA)
substrate
gelatin
methacryloyl
(GelMA)
tips
with
encapsulated
Cv.
Once
CvMN
is
applied
wound,
the
PVA
basal
layer
rapidly
dissolved
short
time,
while
noncytotoxic
biocompatible
GelMA
remain
skin.
By
taking
advantage
photosynthesis
Cv,
would
continuously
produced
green
way
released
from
controlled
manner.
Both
vitro
vivo
results
showed
could
promote
angiogenesis
enhance
mice
effectively.
remarkable
therapeutic
effect
mainly
attributed
continuous
generation
presence
antioxidant
vitamins,
γ-linolenic
acid,
linoleic
acid
Thus,
provides
promising
strategy
for
more
possibility
clinical
transformations.
