Advanced Healthcare Materials,
Год журнала:
2024,
Номер
13(18)
Опубликована: Март 23, 2024
Intense
and
persistent
oxidative
stress,
excessive
inflammation,
impaired
angiogenesis
severely
hinder
diabetic
wound
healing.
Bioactive
hydrogel
dressings
with
immunoregulatory
proangiogenic
properties
have
great
promise
in
treating
wounds.
However,
the
therapeutic
effects
of
always
depend
on
drugs
side
effects,
expensive
cytokines,
cell
therapies.
Herein,
a
novel
dynamic
borate-bonds
crosslinked
hybrid
multifunctional
photothermal
are
developed
to
regulate
microenvironment
sites
accelerate
whole
process
its
healing
without
additional
medication.
The
is
composed
phenylboronic
acid-modified
chitosan
hyaluronic
acid
(HA)
by
tannic
(TA)
through
borate
bonds
Prussian
blue
nanoparticles
(PBNPs)
response
characteristics
embedded
polymer
networks.
results
indicate
hydrogels
show
inherent
broad-spectrum
antioxidative
activities
integrated
interaction
bonds,
TA,
PBNPs.
Meanwhile,
combined
regulation
macrophage
phenotype
HA,
inflammatory
wounds
transformed.
Moreover,
then
enhanced
mild
effect
PBNPs,
followed
promoted
epithelialization
collagen
deposition.
In
summary,
this
system
accelerates
all
stages
repair
immunomodulation,
proangiogenesis,
showing
potential
applications
management.
Advanced Electronic Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 14, 2025
Abstract
As
hydrogel
research
progresses,
hydrogels
are
becoming
essential
tools
in
bioelectronics
and
biotechnology.
This
review
explores
the
diverse
range
of
natural
synthetic
gel
materials
tailored
for
specific
bioelectronic
applications,
with
a
focus
on
their
integration
electronic
components
to
create
responsive,
multifunctional
systems.
The
role
Artificial
Intelligence
(AI)
advancing
design
functionality
from
optimizing
material
properties
enabling
precise,
predictive
modeling
is
investigated.
Furthermore,
recent
innovations
that
harness
synergy
between
hydrogels,
electronics,
AI
discussed,
emphasizing
potential
these
drive
future
advances
biomedical
technologies.
AI‐driven
approaches
transforming
development
applications
wound
healing,
biosensing,
drug
delivery,
tissue
engineering.
Advanced Healthcare Materials,
Год журнала:
2023,
Номер
13(2)
Опубликована: Окт. 13, 2023
Diabetic
chronic
wounds
cause
a
significant
amount
of
pain
to
patients
because
their
low
cure
rates
and
high
recurrence
rates.
Traditional
approaches
treating
diabetic
often
involve
the
delivery
drugs
or
cytokines
that
regulate
microenvironment
eliminate
bacterial
infection
in
wound
area,
but
they
are
passive
controlling
cell
behaviors
may
lead
drug
resistance.
Emerging
drug-free
treatments
important
for
convenient,
effective,
safe
treatment
strategies.
However,
current
cannot
fully
promote
tissue
regeneration
prevent
infections.
Here,
efficacy
negatively
charged
fiber
dressing
promoting
healing
is
investigated.
The
can
generate
reactive
oxygen
species
inhibit
reproduction
with
assistance
ultrasound
during
inflammatory
phase.
Furthermore,
provides
an
electrostatic
field
regulates
cellular
behavior
proliferative
phases.
In
particular,
fibroblast
migration
induce
macrophage
polarization
neovascularization
without
any
additional
drugs.
It
demonstrated
this
strategy
enables
mouse
model,
achieving
effective
closure
over
12-day
cycle
providing
therapeutic
care.
