Macromolecular Bioscience,
Год журнала:
2023,
Номер
23(11)
Опубликована: Июнь 2, 2023
Abstract
Bacterial
adhesion
and
subsequent
biofilm
formation
on
the
surfaces
of
synthetic
materials
imposes
a
significant
burden
in
various
fields,
which
can
lead
to
infections
patients
or
reduce
service
life
industrial
devices.
Therefore,
there
is
increasing
interest
imbuing
with
antibacterial
properties.
Bioinspired
superhydrophobic
high
water
contact
angles
(>150°)
exhibit
excellent
surface
repellency
against
contaminations,
thereby
preventing
initial
bacterial
inhibiting
formation.
However,
conventional
typically
lack
long‐term
durability
are
incapable
achieving
persistent
efficacy
adhesion.
To
overcome
these
limitations,
recent
decades,
dual‐function
both
bacteria‐repelling
bacteria‐killing
properties
have
been
developed
by
introducing
bactericidal
components.
These
demonstrated
improved
performance
addressing
issues
associated
surface‐attached
bacteria.
This
review
summarizes
advancements
surfaces.
First,
brief
overview
fabrication
strategies
mechanism
provided
then
classified
into
three
types
based
mechanism:
i)
mechanotherapy,
ii)
chemotherapy,
iii)
phototherapy.
Finally,
limitations
challenges
current
research
discussed
future
perspectives
this
promising
area
proposed.
Biomaterials Science,
Год журнала:
2023,
Номер
11(15), С. 5108 - 5128
Опубликована: Янв. 1, 2023
This
review
mainly
summarises
the
recent
progress
in
development
of
organic
photosensitizers,
including
porphyrins,
chlorophyll,
phenothiazines,
xanthenes
and
aggregation-induced
emission
for
antimicrobial
photodynamic
therapy.
Bioengineering,
Год журнала:
2023,
Номер
10(2), С. 165 - 165
Опубликована: Янв. 27, 2023
A
myocardial
infarction
(MI)
is
the
leading
cause
of
morbidity
and
mortality,
seriously
threatens
human
health,
becomes
a
major
health
burden
our
society.
It
urgent
to
pursue
effective
therapeutic
strategies
for
regeneration
restore
function
after
MI.
This
review
discusses
role
hydrogel
in
cardiac
repair
Hydrogel-based
patches
injectable
hydrogels
are
most
commonly
used
applications
medicine.
With
hydrogels,
bioactive
compounds
cells
can
be
delivered
situ,
promoting
situ
regeneration,
while
hydrogel-based
reduce
wall
stress,
which
passively
inhibits
ventricular
expansion.
work
as
mechanically
supportive
biomaterials.
In
medicine,
clinical
trials
commercial
products
limited.
Biomaterials,
biochemistry,
biological
actives,
such
intelligent
exosome
patches,
may
serve
an
treatment
MI
future,
still
under
development.
Further
investigation
feasibility
warranted.
We
anticipate
having
immense
translational
potential
near
future.
Molecules,
Год журнала:
2023,
Номер
28(16), С. 6085 - 6085
Опубликована: Авг. 16, 2023
Indocyanine
green
(ICG)
is
an
important
kind
of
near
infrared
(NIR)
photosensitive
molecules
for
PTT/PDT
therapy
as
well
imaging.
When
exposed
to
NIR
light,
ICG
can
produce
reactive
oxygen
species
(ROS),
which
kill
cancer
cells
and
pathogenic
bacteria.
Moreover,
the
absorbed
light
also
be
converted
into
heat
by
eliminate
cells.
In
addition,
it
performs
exceptionally
in
optical
imaging-guided
tumor
antimicrobial
due
its
deeper
tissue
penetration
low
photobleaching
properties
near-infrared
region
compared
other
dyes.
order
solve
problems
water
stability
multi-function
problem
molecules,
composite
nanomaterials
based
on
have
been
designed
widely
used,
especially
fields
tumors
sterilization.
So
far,
their
materials
become
one
most
famous
sensitive
materials.
However,
there
no
corresponding
review
articles
focused
molecules.
this
review,
molecular
structure
ICG,
material
design,
light-
triggered
anti-tumor,
antibacterial,
clinical
applications
are
reviewed
detail,
great
significance
related
research.
Advanced Functional Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Июнь 14, 2024
Abstract
Antimicrobial
photodynamic
therapy
(aPDT)
has
emerged
as
an
appealing
therapeutic
option
against
biofilm
infections.
However,
effectively
penetrating
the
dense
barrier
of
and
anchoring
bacteria
to
achieve
elimination
wound
healing
under
hypoxic
environments
remains
a
challenge
for
aPDT.
Herein,
three
type
I/II
Hypocrellin
B
(HB)‐cationic
photosensitizers
(HB‐P,
HB‐TP,
HB‐TTP)
are
designed
based
on
multi‐cationic
long
chains
molecular
engineering
strategy.
With
increasing
number
introduced
cations,
reactive
oxygen
species
(ROS)
production
bacterial‐anchoring
abilities
HB‐cationic
greatly
enhanced.
Notably,
HB‐TTP
demonstrates
higher
aPDT
activity
broad‐spectrum
antibacterial
properties.
Furthermore,
address
conundrum
biofilm‐infected
wounds,
ROS‐responsive
core‐shell
microneedle
(HB‐TTP&EGF@MN)
is
by
biphasically
integrating
growth
factor.
When
penetrates
biofilm,
shell
quickly
dissolves
releases
removal
laser
irradiation.
The
core
subsequently
degraded
slowly
in
presence
endogenous
ROS
within
wound,
facilitating
sustained
release
factor
promote
tissue
regeneration.
This
work
not
only
provides
effective
strategy
rational
design
efficient
antimicrobial
agents
but
also
proposes
innovative
ideas
development
controlled‐release
pharmaceutical
materials
synergize
Advanced Healthcare Materials,
Год журнала:
2024,
Номер
13(27)
Опубликована: Июль 27, 2024
Abstract
The
threat
posed
by
antibiotic‐resistant
bacteria
and
the
challenge
of
biofilm
formation
has
highlighted
inadequacies
conventional
antibacterial
therapies,
leading
to
increased
interest
in
photodynamic
therapy
(aPDT)
recent
years.
This
approach
offers
advantages
such
as
minimal
invasiveness,
low
systemic
toxicity,
notable
effectiveness
against
drug‐resistant
bacterial
strains.
Porphyrins
their
derivatives,
known
for
high
molar
extinction
coefficients
singlet
oxygen
quantum
yields,
have
emerged
crucial
photosensitizers
aPDT.
However,
practical
application
is
hindered
challenges
poor
water
solubility
aggregation‐induced
quenching.
To
address
these
limitations,
extensive
research
focused
on
development
porphyrin‐based
nanomaterials
aPDT,
enhancing
efficacy
sterilization
broadening
range
antimicrobial
activity.
review
provides
an
overview
various
utilized
aPDT
eradication
years,
including
porphyrin‐loaded
inorganic
nanoparticles,
polymer
assemblies,
supramolecular
metal–organic
frameworks
(MOFs),
covalent
organic
(COFs).
Additionally,
insights
into
prospects
offered,
highlighting
its
potential
implementation.
Advanced Functional Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 23, 2025
Abstract
In
the
face
of
escalating
antibiotic
resistance
crisis,
world
is
embroiled
in
a
silent
“antibacterial
war”.
Scientists
are
actively
searching
for
innovative
antibacterial
materials
that
can
be
used
as
effective
weapons
against
bacterial
infections.
As
promising
new
crystalline
porous
polymer
materials,
covalent
organic
frameworks
(COFs)
gradually
revealing
their
vast
potential
applications.
This
study
investigates
classification
COF‐based
agents,
provides
comprehensive
overview
applications
and
research
advancements,
explores
strategies
employed
by
COF
materials.
Furthermore,
challenges
outlined
lie
ahead
future
application
agents
insights
into
prospects
within
field
offered.
Through
these
efforts,
aim
to
accelerate
advancements
COFs
manufacturing
technology,
promote
innovation
applications,
contribute
public
health.
