Damage
to
bones
resulting
from
trauma
and
tumors
poses
a
significant
challenge
human
health.
Consequently,
current
research
in
bone
damage
healing
centers
on
developing
three-dimensional
(3D)
scaffolding
materials
that
facilitate
enhance
the
regeneration
of
fractured
tissues.
In
this
context,
careful
selection
preparation
processes
is
essential
for
creating
demanding
scaffolds
tissue
engineering.
This
done
optimize
bones.
study
comprehensively
analyses
latest
scientific
advancements
difficulties
creation.
Initially,
we
clarified
composition
process
by
which
repairs
itself.
The
review
summarizes
primary
uses
materials,
both
inorganic
organic,
addition,
present
comprehensive
most
recent
mainstream
techniques
used
prepare
We
also
examine
distinct
advantages
each
method
great
detail.
article
thoroughly
examines
potential
paths
obstacles
engineering
clinical
applications.
Biomacromolecules,
Год журнала:
2024,
Номер
25(2), С. 564 - 589
Опубликована: Янв. 4, 2024
As
a
biodegradable
and
biocompatible
protein
derived
from
collagen,
gelatin
has
been
extensively
exploited
as
fundamental
component
of
biological
scaffolds
drug
delivery
systems
for
precise
medicine.
The
easily
engineered
holds
great
promise
in
formulating
various
to
protect
enhance
the
efficacy
drugs
improving
safety
effectiveness
numerous
pharmaceuticals.
remarkable
biocompatibility
adjustable
mechanical
properties
permit
construction
active
3D
accelerate
regeneration
injured
tissues
organs.
In
this
Review,
we
delve
into
diverse
strategies
fabricating
functionalizing
gelatin-based
structures,
which
are
applicable
gene
well
tissue
engineering.
We
emphasized
advantages
derivatives,
including
methacryloyl
gelatin,
polyethylene
glycol-modified
thiolated
alendronate-modified
gelatin.
These
derivatives
exhibit
excellent
physicochemical
properties,
allowing
fabrication
tailor-made
structures
biomedical
applications.
Additionally,
explored
latest
developments
modulation
their
by
combining
additive
materials
manufacturing
platforms,
outlining
design
multifunctional
micro-,
nano-,
macrostructures.
While
discussing
current
limitations,
also
addressed
challenges
that
need
be
overcome
clinical
translation,
high
costs,
limited
application
scenarios,
potential
immunogenicity.
This
Review
provides
insight
how
structural
chemical
engineering
can
leveraged
pave
way
significant
advancements
applications
improvement
patient
outcomes.
Journal of Nanobiotechnology,
Год журнала:
2024,
Номер
22(1)
Опубликована: Авг. 27, 2024
With
the
accelerated
aging
tendency,
osteoarthritis
(OA)
has
become
an
intractable
global
public
health
challenge.
Stem
cells
and
their
derivative
exosome
(Exo)
have
shown
great
potential
in
OA
treatment.
Research
this
area
tends
to
develop
functional
microcarriers
for
stem
cell
Exo
delivery
improve
therapeutic
effect.
Herein,
we
a
novel
system
of
Exo-encapsulated
cell-recruitment
hydrogel
from
liquid
nitrogen-assisted
microfluidic
electrospray
Benefited
advanced
droplet
generation
capability
microfluidics
mild
cryogelation
procedure,
resultant
particles
show
uniform
size
dispersion
excellent
biocompatibility.
Moreover,
acryloylated
recruitment
peptides
SKPPGTSS
are
directly
crosslinked
within
by
ultraviolet
irradiation,
thus
simplifying
peptide
coupling
process
preventing
its
premature
release.
The
SKPPGTSS-modified
can
recruit
endogenous
promote
cartilage
repair
released
further
enhances
performance
through
synergistic
effects.
These
features
suggest
that
proposed
microcarrier
is
promising
candidate
Biomacromolecules,
Год журнала:
2024,
Номер
25(4), С. 2243 - 2260
Опубликована: Март 25, 2024
Cartilage
repair
has
been
a
significant
challenge
in
orthopedics
that
not
yet
fully
resolved.
Due
to
the
absence
of
blood
vessels
and
almost
cell-free
nature
mature
cartilage
tissue,
limited
ability
resulted
socioeconomic
pressures.
Polysaccharide
materials
have
recently
widely
used
for
tissue
due
their
excellent
cell
loading,
biocompatibility,
chemical
modifiability.
They
also
provide
suitable
microenvironment
regeneration.
In
this
Review,
we
summarize
techniques
clinically
repair,
focusing
on
polysaccharides,
polysaccharides
differences
between
these
other
materials.
addition,
engineering
strategies
an
outlook
developing
next-generation
regeneration
from
polysaccharides.
This
Review
will
theoretical
guidance
polysaccharide-based
with
clinical
applications
International Journal of Surgery,
Год журнала:
2024,
Номер
110(10), С. 6748 - 6762
Опубликована: Июнь 21, 2024
The
advent
of
personalized
bone
prosthesis
materials
and
their
integration
into
orthopedic
surgery
has
made
a
profound
impact,
primarily
as
result
the
incorporation
three-dimensional
(3D)
printing
technology.
By
leveraging
digital
models
additive
manufacturing
techniques,
3D
enables
creation
customized,
high-precision
implants
tailored
to
address
complex
anatomical
variabilities
challenging
defects.
In
this
review,
we
highlight
significant
progress
in
utilizing
printed
prostheses
across
wide
range
procedures,
including
pelvis,
hip,
knee,
foot,
ankle,
spine
surgeries,
tumor
resections.
preoperative
planning,
surgical
navigation,
postoperative
rehabilitation
not
only
enhances
treatment
outcomes
but
also
reduces
risks,
accelerates
recovery,
optimizes
cost-effectiveness.
Emphasizing
potential
for
care
improved
patient
outcomes,
review
underscores
pivotal
role
advancing
practice
towards
precision,
efficiency,
patient-centric
solutions.
evolving
landscape
holds
promise
revolutionizing
approaches,
enhancing
ultimately
improving
quality
patients.
