Journal of Composites Science,
Год журнала:
2024,
Номер
8(11), С. 457 - 457
Опубликована: Ноя. 4, 2024
Hydrogels
play
a
crucial
role
due
to
their
high-water
content
and
3D
structure,
which
make
them
ideal
for
various
applications
in
biomedicine,
sensing,
beyond.
They
can
be
prepared
from
variety
of
biomaterials,
polymers,
combinations,
allowing
versatility
properties
applications.
include
natural
types
derived
collagen,
gelatin,
alginate,
hyaluronic
acid,
as
well
synthetic
based
on
polyethylene
glycol
(PEG),
polyvinyl
alcohol
(PVA),
polyacrylamide
(PAAm).
Each
type
possesses
distinct
properties,
such
mechanical
strength,
biodegradability,
biocompatibility,
tailored
wound
healing,
contact
lenses,
bioprinting,
tissue
engineering.
The
hydrogels
mimics
environments,
promoting
cell
growth
nutrient
waste
exchange,
supports
the
development
functional
tissues.
serve
scaffolds
engineering
applications,
including
cartilage
bone
regeneration,
vascular
engineering,
organ-on-a-chip
systems.
Additionally,
encapsulate
deliver
therapeutic
agents,
factors
or
drugs,
specific
target
sites
body.
through
three
primary
methods:
physical
crosslinking,
relies
non-covalent
interactions
entanglements
hydrogen
bonding;
chemical
forms
covalent
bonds
between
polymer
chains
create
stable
structure;
irradiation-based
where
UV
irradiation
induces
rapid
hydrogel
formation.
choice
crosslinking
method
depends
desired
hydrogel.
By
providing
biomimetic
environment,
facilitate
differentiation,
support
formation,
aid
regeneration
damaged
diseased
tissues
while
delivering
agents.
This
review
focuses
critical
advancements
processing
routes
development,
summarizing
characterization
application
hydrogels.
It
also
details
key
healing
challenges
future
perspectives
field.
Bioactive Materials,
Год журнала:
2023,
Номер
31, С. 475 - 496
Опубликована: Сен. 9, 2023
In
the
human
body,
almost
all
cells
interact
with
extracellular
matrices
(ECMs),
which
have
tissue
and
organ-specific
compositions
architectures.
These
ECMs
not
only
function
as
cellular
scaffolds,
providing
structural
support,
but
also
play
a
crucial
role
in
dynamically
regulating
various
functions.
This
comprehensive
review
delves
into
examination
of
biofabrication
strategies
used
to
develop
bioactive
materials
that
accurately
mimic
one
or
more
biophysical
biochemical
properties
ECMs.
We
discuss
potential
integration
these
ECM-mimics
range
physiological
pathological
vitro
models,
enhancing
our
understanding
behavior
organization.
Lastly,
we
propose
future
research
directions
for
context
engineering
organ-on-a-chip
applications,
offering
advancements
therapeutic
approaches
improved
patient
outcomes.
Materials Today Bio,
Год журнала:
2024,
Номер
25, С. 101014 - 101014
Опубликована: Фев. 29, 2024
Traditional
hydrogel
design
and
optimization
methods
usually
rely
on
repeated
experiments,
which
is
time-consuming
expensive,
resulting
in
a
slow-moving
of
advanced
development.
With
the
rapid
development
artificial
intelligence
(AI)
technology
increasing
material
data,
AI-energized
hydrogels
for
biomedical
applications
has
emerged
as
revolutionary
breakthrough
materials
science.
This
review
begins
by
outlining
history
AI
potential
advantages
using
hydrogels,
such
prediction
properties,
multi-attribute
optimization,
high-throughput
screening,
automated
discovery,
optimizing
experimental
design,
etc.
Then,
we
focus
various
supported
biomedicine,
including
drug
delivery,
bio-inks
manufacturing,
tissue
repair,
biosensors,
so
to
provide
clear
comprehensive
understanding
researchers
this
field.
Finally,
discuss
future
directions
prospects,
new
perspective
research
novel
applications.
Journal of Nanobiotechnology,
Год журнала:
2024,
Номер
22(1)
Опубликована: Фев. 10, 2024
Abstract
Extracellular
vesicles
have
shown
promising
tissue
recovery-promoting
effects,
making
them
increasingly
sought-after
for
their
therapeutic
potential
in
wound
treatment.
However,
traditional
extracellular
vesicle
applications
suffer
from
limitations
such
as
rapid
degradation
and
short
maintenance
during
administration.
To
address
these
challenges,
a
growing
body
of
research
highlights
the
role
hydrogels
effective
carriers
sustained
release,
thereby
facilitating
healing.
The
combination
with
development
3D
bioprinting
create
composite
hydrogel
systems
boasting
excellent
mechanical
properties
biological
activity,
presenting
novel
approach
to
healing
skin
dressing.
This
comprehensive
review
explores
remarkable
hydrogels,
specifically
suited
loading
vesicles.
We
delve
into
diverse
sources
analyzing
integration
within
formulations
Different
methods
well
bioprinting,
adapted
varying
conditions
construction
strategies,
are
examined
roles
promoting
results
highlight
vesicle-laden
advanced
tools
field
treatment,
offering
both
support
bioactive
functions.
By
providing
an
in-depth
examination
various
that
can
play
healing,
this
sheds
light
on
directions
further
development.
Finally,
we
challenges
associated
application
along
emerging
trends
domain.
discussion
covers
issues
scalability,
regulatory
considerations,
translation
technology
practical
clinical
settings.
In
conclusion,
underlines
significant
contributions
hydrogel-mediated
therapy
regeneration.
It
serves
valuable
resource
researchers
practitioners
alike,
fostering
deeper
understanding
benefits,
applications,
involved
utilizing
Graphical
abstract
Journal of Functional Biomaterials,
Год журнала:
2024,
Номер
15(10), С. 280 - 280
Опубликована: Сен. 25, 2024
Bone
tissue
regeneration
is
a
rapidly
evolving
field
aimed
at
the
development
of
biocompatible
materials
and
devices,
such
as
scaffolds,
to
treat
diseased
damaged
osseous
tissue.
Functional
scaffolds
maintain
structural
integrity
provide
mechanical
support
defect
site
during
healing
process,
while
simultaneously
enabling
or
improving
through
amplified
cellular
cues
between
scaffold
native
tissues.
Ample
research
on
functionalization
has
been
conducted
improve
scaffold–host
interaction,
including
fabrication
techniques,
biomaterial
selection,
surface
modifications,
integration
bioactive
molecular
additives,
post-processing
modifications.
Each
these
methods
plays
crucial
role
in
not
only
but
actively
participate
process
bone
joint
surgery.
This
review
provides
state-of-the-art,
comprehensive
overview
scaffold-based
strategies
used
engineering,
specifically
for
regeneration.
Critical
issues
obstacles
are
highlighted,
applications
advances
described,
future
directions
identified.
Frontiers in Bioengineering and Biotechnology,
Год журнала:
2024,
Номер
12
Опубликована: Июнь 21, 2024
Amongst
the
range
of
bioprinting
technologies
currently
available,
by
material
extrusion
is
gaining
increasing
popularity
due
to
accessibility,
low
cost,
and
absence
energy
sources,
such
as
lasers,
which
may
significantly
damage
cells.
New
applications
extrusion-based
are
systematically
emerging
in
biomedical
field
relation
tissue
organ
fabrication.
Extrusion-based
presents
a
series
specific
challenges
achievable
resolutions,
accuracy
speed.
Resolution
particular
paramount
importance
for
realization
microstructures
(for
example,
vascularization)
within
tissues
organs.
Another
major
theme
research
cell
survival
functional
preservation,
extruded
bioinks
have
cells
subjected
considerable
shear
stresses
they
travel
through
apparatus.
Here,
an
overview
main
available
printing
related
families
materials
(bioinks)
provided.
The
achieving
resolution
whilst
assuring
viability
function
discussed
application
contexts
Frontiers in Bioengineering and Biotechnology,
Год журнала:
2025,
Номер
13
Опубликована: Фев. 11, 2025
Three-dimensional
(3D)
printing
has
rapidly
become
a
transformative
force
in
orthopedic
surgery,
enabling
the
creation
of
highly
customized
and
precise
medical
implants
surgical
tools.
This
review
aims
to
provide
more
systematic
comprehensive
perspective
on
emerging
3D
technologies—ranging
from
extrusion-based
methods
bioink
powder
bed
fusion—and
broadening
array
materials,
including
bioactive
agents
cell-laden
inks.
We
highlight
how
these
technologies
materials
are
employed
fabricate
patient-specific
implants,
guides,
prosthetics,
advanced
tissue
engineering
scaffolds,
significantly
enhancing
outcomes
patient
recovery.
Despite
notable
progress,
field
faces
challenges
such
as
optimizing
mechanical
properties,
ensuring
structural
integrity,
addressing
regulatory
complexities
across
different
regions,
considering
environmental
impacts
cost
barriers,
especially
low-resource
settings.
Looking
ahead,
innovations
smart
functionally
graded
(FGMs),
along
with
advancements
bioprinting,
hold
promise
for
overcoming
obstacles
expanding
capabilities
orthopedics.
underscores
pivotal
role
interdisciplinary
collaboration
ongoing
research
harnessing
full
potential
additive
manufacturing,
ultimately
paving
way
effective,
personalized,
durable
solutions
that
improve
quality
life.
