Food Chemistry, Год журнала: 2025, Номер 471, С. 142828 - 142828
Опубликована: Янв. 9, 2025
Язык: Английский
Bioactive Materials, Год журнала: 2023, Номер 31, С. 475 - 496
Опубликована: Сен. 9, 2023
In the human body, almost all cells interact with extracellular matrices (ECMs), which have tissue and organ-specific compositions architectures. These ECMs not only function as cellular scaffolds, providing structural support, but also play a crucial role in dynamically regulating various functions. This comprehensive review delves into examination of biofabrication strategies used to develop bioactive materials that accurately mimic one or more biophysical biochemical properties ECMs. We discuss potential integration these ECM-mimics range physiological pathological vitro models, enhancing our understanding behavior organization. Lastly, we propose future research directions for context engineering organ-on-a-chip applications, offering advancements therapeutic approaches improved patient outcomes.
Язык: Английский
Процитировано
61
Materials Today Bio, Год журнала: 2024, Номер 25, С. 101014 - 101014
Опубликована: Фев. 29, 2024
Traditional hydrogel design and optimization methods usually rely on repeated experiments, which is time-consuming expensive, resulting in a slow-moving of advanced development. With the rapid development artificial intelligence (AI) technology increasing material data, AI-energized hydrogels for biomedical applications has emerged as revolutionary breakthrough materials science. This review begins by outlining history AI potential advantages using hydrogels, such prediction properties, multi-attribute optimization, high-throughput screening, automated discovery, optimizing experimental design, etc. Then, we focus various supported biomedicine, including drug delivery, bio-inks manufacturing, tissue repair, biosensors, so to provide clear comprehensive understanding researchers this field. Finally, discuss future directions prospects, new perspective research novel applications.
Язык: Английский
Процитировано
47
Journal of Nanobiotechnology, Год журнала: 2024, Номер 22(1)
Опубликована: Фев. 10, 2024
Abstract Extracellular vesicles have shown promising tissue recovery-promoting effects, making them increasingly sought-after for their therapeutic potential in wound treatment. However, traditional extracellular vesicle applications suffer from limitations such as rapid degradation and short maintenance during administration. To address these challenges, a growing body of research highlights the role hydrogels effective carriers sustained release, thereby facilitating healing. The combination with development 3D bioprinting create composite hydrogel systems boasting excellent mechanical properties biological activity, presenting novel approach to healing skin dressing. This comprehensive review explores remarkable hydrogels, specifically suited loading vesicles. We delve into diverse sources analyzing integration within formulations Different methods well bioprinting, adapted varying conditions construction strategies, are examined roles promoting results highlight vesicle-laden advanced tools field treatment, offering both support bioactive functions. By providing an in-depth examination various that can play healing, this sheds light on directions further development. Finally, we challenges associated application along emerging trends domain. discussion covers issues scalability, regulatory considerations, translation technology practical clinical settings. In conclusion, underlines significant contributions hydrogel-mediated therapy regeneration. It serves valuable resource researchers practitioners alike, fostering deeper understanding benefits, applications, involved utilizing Graphical abstract
Язык: Английский
Процитировано
24
International Journal of Biological Macromolecules, Год журнала: 2024, Номер 270, С. 132123 - 132123
Опубликована: Май 17, 2024
Язык: Английский
Процитировано
20
Frontiers in Bioengineering and Biotechnology, Год журнала: 2024, Номер 12
Опубликована: Июнь 21, 2024
Amongst the range of bioprinting technologies currently available, by material extrusion is gaining increasing popularity due to accessibility, low cost, and absence energy sources, such as lasers, which may significantly damage cells. New applications extrusion-based are systematically emerging in biomedical field relation tissue organ fabrication. Extrusion-based presents a series specific challenges achievable resolutions, accuracy speed. Resolution particular paramount importance for realization microstructures (for example, vascularization) within tissues organs. Another major theme research cell survival functional preservation, extruded bioinks have cells subjected considerable shear stresses they travel through apparatus. Here, an overview main available printing related families materials (bioinks) provided. The achieving resolution whilst assuring viability function discussed application contexts
Язык: Английский
Процитировано
19
Journal of Functional Biomaterials, Год журнала: 2024, Номер 15(10), С. 280 - 280
Опубликована: Сен. 25, 2024
Bone tissue regeneration is a rapidly evolving field aimed at the development of biocompatible materials and devices, such as scaffolds, to treat diseased damaged osseous tissue. Functional scaffolds maintain structural integrity provide mechanical support defect site during healing process, while simultaneously enabling or improving through amplified cellular cues between scaffold native tissues. Ample research on functionalization has been conducted improve scaffold–host interaction, including fabrication techniques, biomaterial selection, surface modifications, integration bioactive molecular additives, post-processing modifications. Each these methods plays crucial role in not only but actively participate process bone joint surgery. This review provides state-of-the-art, comprehensive overview scaffold-based strategies used engineering, specifically for regeneration. Critical issues obstacles are highlighted, applications advances described, future directions identified.
Язык: Английский
Процитировано
19
Frontiers in Bioengineering and Biotechnology, Год журнала: 2025, Номер 13
Опубликована: Фев. 11, 2025
Three-dimensional (3D) printing has rapidly become a transformative force in orthopedic surgery, enabling the creation of highly customized and precise medical implants surgical tools. This review aims to provide more systematic comprehensive perspective on emerging 3D technologies—ranging from extrusion-based methods bioink powder bed fusion—and broadening array materials, including bioactive agents cell-laden inks. We highlight how these technologies materials are employed fabricate patient-specific implants, guides, prosthetics, advanced tissue engineering scaffolds, significantly enhancing outcomes patient recovery. Despite notable progress, field faces challenges such as optimizing mechanical properties, ensuring structural integrity, addressing regulatory complexities across different regions, considering environmental impacts cost barriers, especially low-resource settings. Looking ahead, innovations smart functionally graded (FGMs), along with advancements bioprinting, hold promise for overcoming obstacles expanding capabilities orthopedics. underscores pivotal role interdisciplinary collaboration ongoing research harnessing full potential additive manufacturing, ultimately paving way effective, personalized, durable solutions that improve quality life.
Язык: Английский
Процитировано
5
Bioprinting, Год журнала: 2025, Номер unknown, С. e00385 - e00385
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
3
Bioactive Materials, Год журнала: 2025, Номер 48, С. 273 - 293
Опубликована: Фев. 20, 2025
Язык: Английский
Процитировано
3
International Journal of Biological Macromolecules, Год журнала: 2024, Номер 271, С. 132411 - 132411
Опубликована: Май 31, 2024
Язык: Английский
Процитировано
16