Prebiotics empower probiotics with gastrointestinal stress resistance for colon-targeted release to synergistically alleviate colitis

Journal of Controlled Release, Год журнала: 2025, Номер 380, С. 297 - 316

Опубликована: Фев. 7, 2025

Язык: Английский

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The frontier of health: Exploring therapeutic potentials of the microbiome

PharmaNutrition, Год журнала: 2025, Номер unknown, С. 100435 - 100435

Опубликована: Фев. 1, 2025

Язык: Английский

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Extracellular Vesicles from Nanomedicine‐Trained Intestinal Microbiota Substitute for Fecal Microbiota Transplant in Treating Ulcerative Colitis

Advanced Materials, Год журнала: 2024, Номер 36(41)

Опубликована: Июль 29, 2024

Abstract The biosafety concerns associated with fecal microbiota transplant (FMT) limit their clinical application in treating ulcerative colitis (UC). Gut secrete abundant extracellular vesicles (Gm‐EVs), which play a critical role bacteria‐to‐bacteria and bacteria‐to‐host communications. Herein, intestinal are trained using tea leaf lipid/pluronic F127‐coated curcumin nanocrystals (CN@Lp 127 s), can maintain stability during transit through the gastrointestinal tract. Compared FMT, Gm‐EVs derived from healthy mice significantly improve treatment outcomes against UC by reducing colonic inflammatory responses, restoring barrier function, rebalancing microbiota. Strikingly, obtained CN@Lp ‐trained exhibit superior therapeutic effect on compared to groups receiving FMT mice, mice. Oral administration of not only alleviates inflammation, promotes mucosal repair, regulates gut but also purine metabolism decrease uric acid level, resulting robust improvement UC. This study demonstrates efficacy nanomedicine‐trained regulating immune microenvironment, microbiota, colon. These EVs provide an alternative platform replace as for

Язык: Английский

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Copper–luteolin nanocomplexes for Mediating multifaceted regulation of oxidative stress, intestinal barrier, and gut microbiota in inflammatory bowel disease

Bioactive Materials, Год журнала: 2024, Номер 46, С. 118 - 133

Опубликована: Дек. 11, 2024

Язык: Английский

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Clickable nanozyme enhances precise colonization of probiotics for ameliorating inflammatory bowel disease

Journal of Controlled Release, Год журнала: 2024, Номер 373, С. 749 - 765

Опубликована: Авг. 2, 2024

Convincing evidence suggests that aberrant gut microbiota changes play a critical role in the progression and pathogenesis of inflammatory bowel disease (IBD). Probiotic therapeutic interventions targeting may provide alternative avenues to treat IBD, but currently available probiotics often suffer from low intestinal colonization limited capability. Here, we developed azido (N

Язык: Английский

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The Role of Nanoparticle Morphology on Enhancing Delivery of Budesonide for Treatment of Inflammatory Bowel Disease

ACS Applied Materials & Interfaces, Год журнала: 2024, Номер 16(26), С. 33081 - 33092

Опубликована: Июнь 18, 2024

Inflammatory bowel disease (IBD) is a chronic and recurrent inflammatory that affects the gastrointestinal tract. The major hurdles impeding IBD treatment are low targeting efficiency short retention time of drugs in sites. Nanoparticles with specific shapes have demonstrated ability to improve mucus cellular uptake. Herein, mesoporous silica nanoparticles (MSNs) various morphologies were used deliver budesonide (BUD) for IBD. therapeutic efficacy strongly dependent on their shapes. system comprises different MSNs as carriers (BUD), along Eudragit S100 enteric release shell. encapsulation not only improved stability MSNs-BUD tract but also conferred pH-responsive drug properties. Then, efficiently BUD colon site, special shape plays critical role enhancing permeability layer. Among them, dendritic (MSND) effectively reduced myeloperoxidase (MPO) activity levels cytokines due long rapid sites, thereby against colitis. Given pH-responsivity S100, loaded voids MSND (E@MSNs-BUD) could penetrate mucous layer be accurately delivered minor side effects. This expected complement current strategies

Язык: Английский

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Orally Deliverable Microalgal-Based Carrier with Selenium Nanozymes for Alleviation of Inflammatory Bowel Disease

ACS Applied Materials & Interfaces, Год журнала: 2024, Номер unknown

Опубликована: Сен. 12, 2024

Excessive reactive oxygen species (ROS) is a hallmark of both the onset and progression inflammatory bowel disease (IBD), where continuous cycle ROS inflammation drives diseases. The design oral antioxidant nanoenzymes for scavenging has emerged as promising strategy to intervene in IBD. However, practical application these limited due their single catalytical property significantly impacted by substantial leakage upper gastrointestinal tract. This study introduces novel delivery system, SP@CS-SeNPs, combining natural microalgae

Язык: Английский

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Modification of physicochemical, antioxidant, and antibacterial properties of chitosan film with curcumin-loaded TA/Fe nanoparticles

Food Hydrocolloids, Год журнала: 2024, Номер 160, С. 110722 - 110722

Опубликована: Окт. 11, 2024

Язык: Английский

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Inulin Hydrogel Loaded with Self-Assembled Nanoparticles of Curcumin and Glycyrrhizic Acid for Inflammatory Bowel Disease Treatment Via Anti-Inflammation, Antioxidation, and Microbiota Modulation

Опубликована: Янв. 1, 2025

Язык: Английский

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A Dual-Polysaccharide (Carboxylated Chitosan-Carboxymethyl Cellulose Sodium) Gastrointestinal Dynamic Response in Situ Hydrogel for Optimized Oral Targeted Ibd Therapy

Опубликована: Янв. 1, 2025

Язык: Английский

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