Indigo naturalis as a potential drug in the treatment of ulcerative colitis: a comprehensive review of current evidence DOI Creative Commons
Yu Hu, Liulin Chen, Zhen Ye

et al.

Pharmaceutical Biology, Journal Year: 2024, Volume and Issue: 62(1), P. 818 - 832

Published: Oct. 30, 2024

Ulcerative colitis (UC) is an intractable inflammatory bowel disease that threatens the health of patients. The limited availability therapeutic strategies makes it imperative to explore more efficient and safer drugs.

Language: Английский

Prebiotics empower probiotics with gastrointestinal stress resistance for colon-targeted release to synergistically alleviate colitis DOI

Haihua Ji,

Xiao-Chen Yan, Li Zhang

et al.

Journal of Controlled Release, Journal Year: 2025, Volume and Issue: 380, P. 297 - 316

Published: Feb. 7, 2025

Language: Английский

Citations

3
The frontier of health: Exploring therapeutic potentials of the microbiome DOI

Mohammad Abavisani,

Sobhan Karbas Foroushan, Prashant Kesharwani

et al.

PharmaNutrition, Journal Year: 2025, Volume and Issue: unknown, P. 100435 - 100435

Published: Feb. 1, 2025

Language: Английский

Citations

2
Extracellular Vesicles from Nanomedicine‐Trained Intestinal Microbiota Substitute for Fecal Microbiota Transplant in Treating Ulcerative Colitis DOI Open Access

Menghang Zu,

Ga Liu,

Haiting Xu

et al.

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(41)

Published: July 29, 2024

Abstract The biosafety concerns associated with fecal microbiota transplant (FMT) limit their clinical application in treating ulcerative colitis (UC). Gut secrete abundant extracellular vesicles (Gm‐EVs), which play a critical role bacteria‐to‐bacteria and bacteria‐to‐host communications. Herein, intestinal are trained using tea leaf lipid/pluronic F127‐coated curcumin nanocrystals (CN@Lp 127 s), can maintain stability during transit through the gastrointestinal tract. Compared FMT, Gm‐EVs derived from healthy mice significantly improve treatment outcomes against UC by reducing colonic inflammatory responses, restoring barrier function, rebalancing microbiota. Strikingly, obtained CN@Lp ‐trained exhibit superior therapeutic effect on compared to groups receiving FMT mice, mice. Oral administration of not only alleviates inflammation, promotes mucosal repair, regulates gut but also purine metabolism decrease uric acid level, resulting robust improvement UC. This study demonstrates efficacy nanomedicine‐trained regulating immune microenvironment, microbiota, colon. These EVs provide an alternative platform replace as for

Language: Английский

Citations

14
Copper–luteolin nanocomplexes for Mediating multifaceted regulation of oxidative stress, intestinal barrier, and gut microbiota in inflammatory bowel disease DOI Creative Commons

Wanyue Fu,

Zhongshi Huang, Weiqi Li

et al.

Bioactive Materials, Journal Year: 2024, Volume and Issue: 46, P. 118 - 133

Published: Dec. 11, 2024

Language: Английский

Citations

6
Clickable nanozyme enhances precise colonization of probiotics for ameliorating inflammatory bowel disease DOI Creative Commons
Dong Fang,

Liangwen Hao,

Lin Wang

et al.

Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 373, P. 749 - 765

Published: Aug. 2, 2024

Convincing evidence suggests that aberrant gut microbiota changes play a critical role in the progression and pathogenesis of inflammatory bowel disease (IBD). Probiotic therapeutic interventions targeting may provide alternative avenues to treat IBD, but currently available probiotics often suffer from low intestinal colonization limited capability. Here, we developed azido (N

Language: Английский

Citations

5
The Role of Nanoparticle Morphology on Enhancing Delivery of Budesonide for Treatment of Inflammatory Bowel Disease DOI
Qiu‐Yu Li, Wenjuan Liu,

Kaiheng Liu

et al.

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(26), P. 33081 - 33092

Published: June 18, 2024

Inflammatory bowel disease (IBD) is a chronic and recurrent inflammatory that affects the gastrointestinal tract. The major hurdles impeding IBD treatment are low targeting efficiency short retention time of drugs in sites. Nanoparticles with specific shapes have demonstrated ability to improve mucus cellular uptake. Herein, mesoporous silica nanoparticles (MSNs) various morphologies were used deliver budesonide (BUD) for IBD. therapeutic efficacy strongly dependent on their shapes. system comprises different MSNs as carriers (BUD), along Eudragit S100 enteric release shell. encapsulation not only improved stability MSNs-BUD tract but also conferred pH-responsive drug properties. Then, efficiently BUD colon site, special shape plays critical role enhancing permeability layer. Among them, dendritic (MSND) effectively reduced myeloperoxidase (MPO) activity levels cytokines due long rapid sites, thereby against colitis. Given pH-responsivity S100, loaded voids MSND (E@MSNs-BUD) could penetrate mucous layer be accurately delivered minor side effects. This expected complement current strategies

Language: Английский

Citations

4
Orally Deliverable Microalgal-Based Carrier with Selenium Nanozymes for Alleviation of Inflammatory Bowel Disease DOI
Tao Chen,

Xuesong Chi,

Yangjing Li

et al.

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 12, 2024

Excessive reactive oxygen species (ROS) is a hallmark of both the onset and progression inflammatory bowel disease (IBD), where continuous cycle ROS inflammation drives diseases. The design oral antioxidant nanoenzymes for scavenging has emerged as promising strategy to intervene in IBD. However, practical application these limited due their single catalytical property significantly impacted by substantial leakage upper gastrointestinal tract. This study introduces novel delivery system, SP@CS-SeNPs, combining natural microalgae

Language: Английский

Citations

4
Modification of physicochemical, antioxidant, and antibacterial properties of chitosan film with curcumin-loaded TA/Fe nanoparticles DOI

Shuifang Mao,

Yujun Zeng, Yanming Ren

et al.

Food Hydrocolloids, Journal Year: 2024, Volume and Issue: 160, P. 110722 - 110722

Published: Oct. 11, 2024

Language: Английский

Citations

4
Inulin Hydrogel Loaded with Self-Assembled Nanoparticles of Curcumin and Glycyrrhizic Acid for Inflammatory Bowel Disease Treatment Via Anti-Inflammation, Antioxidation, and Microbiota Modulation DOI
Jiaxin Wu,

Leyan Wang,

Lu Han

et al.

Published: Jan. 1, 2025

Language: Английский

Citations

0
A Dual-Polysaccharide (Carboxylated Chitosan-Carboxymethyl Cellulose Sodium) Gastrointestinal Dynamic Response in Situ Hydrogel for Optimized Oral Targeted Ibd Therapy DOI
Yuchen Zhang,

Kailai Liu,

Yunhe Zheng

et al.

Published: Jan. 1, 2025

Language: Английский

Citations

0