Innovating intervertebral disc degeneration therapy: Harnessing the power of extracellular vesicles
Journal of Orthopaedic Translation,
Год журнала:
2025,
Номер
50, С. 44 - 55
Опубликована: Янв. 1, 2025
Язык: Английский
Dissolving Microneedles as In Situ Chemical Reaction Chambers: from Design Strategies to Versatile Biomedical Applications
Advanced Functional Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 10, 2025
Abstract
The
skin
microenvironment
is
a
highly
intricate
and
dynamic
system,
characterized
by
an
acidic
pH,
diverse
microbiota,
various
metabolites,
numerous
enzymes,
creating
both
challenges
opportunities
for
the
development
of
innovative
drug
delivery
systems.
Dissolving
Microneedles
(MNs)
have
emerged
as
promising,
pain‐free
alternative
to
conventional
invasive
injections,
offering
ability
deliver
therapeutics
through
gradual
degradation
within
skin's
interstitial
fluids.
Building
upon
unique
properties
dissolving
MNs,
novel
concept
introduced
wherein
MNs
serve
in
situ
chemical
reaction
chambers.
In
this
framework,
can
reactants
or
catalysts
skin,
enabling
initiation
specific
reactions,
such
prodrug
activation
targeted
therapy,
harmful
enhanced
synthesis
beneficial
molecules.
Moreover,
review
systematically
explores
potential
chambers,
discussing
key
aspects
their
sustained
release
mechanisms,
design
strategies,
range
therapeutic
applications.
Finally,
forward‐looking
perspective
provided
on
future
addressing
broader
clinical
translation
application
personalized
medicine.
Язык: Английский
Cutting-Edge Biomaterials in Intervertebral Disc Degeneration Tissue Engineering
Pharmaceutics,
Год журнала:
2024,
Номер
16(8), С. 979 - 979
Опубликована: Июль 24, 2024
Intervertebral
disc
degeneration
(IVDD)
stands
as
the
foremost
contributor
to
low
back
pain
(LBP),
imposing
a
substantial
weight
on
world
economy.
Traditional
treatment
modalities
encompass
both
conservative
approaches
and
surgical
interventions;
however,
former
falls
short
in
halting
IVDD
progression,
while
latter
carries
inherent
risks.
Hence,
quest
for
an
efficacious
method
reverse
onset
is
paramount.
Biomaterial
delivery
systems,
exemplified
by
hydrogels,
microspheres,
microneedles,
renowned
their
exceptional
biocompatibility,
biodegradability,
biological
efficacy,
mechanical
attributes,
have
found
widespread
application
bone,
cartilage,
various
tissue
engineering
endeavors.
Consequently,
IVD
has
emerged
burgeoning
field
of
interest.
This
paper
succinctly
introduces
intervertebral
(IVD)
structure
pathophysiology
IVDD,
meticulously
classifies
biomaterials
repair,
reviews
recent
advances
field.
Particularly,
strengths
weaknesses
are
emphasized,
potential
avenues
future
research
suggested.
Язык: Английский
Responsive porous microneedles with riboflavin ocular microinjection capability for facilitating corneal crosslinking
Journal of Nanobiotechnology,
Год журнала:
2024,
Номер
22(1)
Опубликована: Сен. 28, 2024
Язык: Английский
The pathogenesis and targeted therapies of intervertebral disc degeneration induced by cartilage endplate inflammation
Frontiers in Cell and Developmental Biology,
Год журнала:
2024,
Номер
12
Опубликована: Дек. 2, 2024
Intervertebral
disc
degeneration
(IVDD)
is
the
leading
cause
of
low
back
pain,
where
and
death
nucleus
pulposus
cells
within
intervertebral
(IVD)
can
be
obviously
revealed.
This
result
in
an
imbalance
extracellular
matrix
due
to
loss
proteoglycans
water
content,
which
further
lead
catabolic
anabolic
dysfunction
IVD.
Recently,
cartilage
endplate
(CEP)
during
aging
has
drawn
large
attention
its
essential
functions
contributing
nutrient
exchange
maintaining
IVD
homeostasis.
Furthermore,
inflammation
disturbed
homeostasis
CEP
not
only
accelerate
degradation
matrix,
but
also
exacerbate
IVDD
by
causing
cell
through
other
pathological
factors.
Here
this
review,
we
summarized
possible
factors
underlying
mechanisms
inflammation-induced
IVDD,
including
exosomes
degeneration,
calcification,
ferroptosis,
mechanical
changes,
senescence.
Besides,
changes
miRNAs,
pain-related
neural
reflex
arc
pathways
associated
with
are
reviewed.
In
addition,
new
strategies
specifically
designed
for
discussed
last
section.
We
hope
paper
offer
some
insights
advancing
novel
treating
serve
as
a
valuable
reference
researchers
field.
Язык: Английский
Endplate chondrocyte-derived exosomal miR-128-3p mitigates intervertebral disc degeneration by targeting TRAF6 via the miR-128-3p/TRAF6 axis to suppress pyroptosis
International Immunopharmacology,
Год журнала:
2024,
Номер
143, С. 113620 - 113620
Опубликована: Ноя. 16, 2024
Intervertebral
disc
degeneration
(IVDD)
is
a
leading
cause
of
chronic
back
pain
and
significantly
impacts
quality
life.
The
pathogenesis
IVDD
largely
driven
by
inflammation,
pyroptosis,
extracellular
matrix
(ECM)
degradation,
which
current
therapies
fail
to
adequately
address.
In
this
study,
we
explore
the
therapeutic
potential
exosomes
derived
from
endplate
chondrocytes
(EPCs),
with
particular
focus
on
microRNA
miR-128-3p.
Our
findings
reveal
that
isolated
third-generation
EPCs,
enriched
miR-128-3p,
exhibit
potent
anti-inflammatory
anti-pyroptotic
effects
in
lipopolysaccharide-treated
nucleus
pulposus
cells,
are
key
contributors
pathology.
Specifically,
demonstrate
miR-128-3p
delivered
via
EPC-derived
directly
targets
TRAF6,
effectively
suppressing
activation
NF-κB
signaling
pathway,
known
play
pivotal
role
inflammation
ECM
breakdown,
marked
reduction
pro-inflammatory
cytokine
release
mitigation
degradation.
Importantly,
EPC
exosomes,
higher
levels
showed
superior
efficacy
compared
fifth-generation
underscoring
critical
mediating
these
protective
effects.
research
highlights
promise
particularly
those
rich
as
novel,
cell-free
approach
for
IVDD.
Unlike
treatments
primarily
symptom
management,
our
molecular
pathways
underlying
progression,
including
By
elucidating
miR-128-3p/TRAF6
axis,
study
provides
foundation
development
targeted,
biologically
based
interventions
aimed
at
halting
or
even
reversing
IVDD,
thereby
offering
hope
more
effective
lasting
options.
Язык: Английский