Molecules,
Год журнала:
2016,
Номер
21(3), С. 264 - 264
Опубликована: Фев. 25, 2016
Nowadays,
there
are
some
molecules
that
have
shown
over
the
years
a
high
capacity
to
act
against
relevant
pathologies
such
as
cardiovascular
disease,
neurodegenerative
disorders
or
cancer.
This
article
provides
brief
review
about
origin,
bioavailability
and
new
research
on
curcumin
synthetized
derivatives.
It
examines
beneficial
effects
health,
delving
into
aspects
cancer,
effects,
metabolic
syndrome,
antioxidant
capacity,
anti-inflammatory
properties,
neurological,
liver
respiratory
disorders.
Thanks
all
these
activities,
is
positioned
an
interesting
nutraceutical.
reason
why
it
has
been
subjected
several
modifications
in
its
structure
administration
form
permitted
increase
effectiveness
different
diseases,
decreasing
mortality
morbidity
associated
pathologies.
Turmeric,
a
spice
that
has
long
been
recognized
for
its
medicinal
properties,
received
interest
from
both
the
medical/scientific
world
and
culinary
enthusiasts,
as
it
is
major
source
of
polyphenol
curcumin.
It
aids
in
management
oxidative
inflammatory
conditions,
metabolic
syndrome,
arthritis,
anxiety,
hyperlipidemia.
may
also
help
exercise-induced
inflammation
muscle
soreness,
thus
enhancing
recovery
performance
active
people.
In
addition,
relatively
low
dose
complex
can
provide
health
benefits
people
do
not
have
diagnosed
conditions.
Most
these
be
attributed
to
antioxidant
anti-inflammatory
effects.
Ingesting
curcumin
by
itself
does
lead
associated
due
poor
bioavailability,
which
appears
primarily
absorption,
rapid
metabolism,
elimination.
There
are
several
components
increase
bioavailability.
For
example,
piperine
component
black
pepper
and,
when
combined
with
curcumin,
shown
bioavailability
2000%.
Curcumin
agents
provides
multiple
benefits.
The
purpose
this
review
brief
overview
plethora
research
regarding
Molecular Therapy,
Год журнала:
2010,
Номер
18(9), С. 1606 - 1614
Опубликована: Июнь 22, 2010
Monocyte-derived
myeloid
cells
play
vital
roles
in
inflammation-related
autoimmune/inflammatory
diseases
and
cancers.
Here,
we
report
that
exosomes
can
deliver
anti-inflammatory
agents,
such
as
curcumin,
to
activated
vivo.
This
technology
provides
a
means
for
drugs,
target
the
inflammatory
well
overcome
unwanted
off-target
effects
limit
their
utility.
Using
delivery
vehicle,
provide
evidence
curcumin
delivered
by
is
more
stable
highly
concentrated
blood.
We
show
specificity
determined
exosomes,
improvement
of
activity
achieved
directing
associated
with
therapeutic,
but
not
toxic,
effects.
Furthermore,
validate
therapeutic
relevance
this
technique
lipopolysaccharide
(LPS)-induced
septic
shock
mouse
model.
further
lipid
alone,
are
required
enhanced
curcumin.
The
using
drug
carrier
creates
opportunities
treatments
many
without
significant
side
due
innocent
bystander
or
Acta Pharmaceutica Sinica B,
Год журнала:
2016,
Номер
6(4), С. 287 - 296
Опубликована: Март 9, 2016
Exosomes
are
small
intracellular
membrane-based
vesicles
with
different
compositions
that
involved
in
several
biological
and
pathological
processes.
The
exploitation
of
exosomes
as
drug
delivery
vehicles
offers
important
advantages
compared
to
other
nanoparticulate
systems
such
liposomes
polymeric
nanoparticles;
non-immunogenic
nature
due
similar
composition
body׳s
own
cells.
In
this
article,
the
origin
structure
well
their
functions
outlined.
We
will
then
focus
on
specific
applications
pharmaceutical
development.
An
overview
challenges
faced
when
using
a
also
be
discussed.
Critical Reviews in Food Science and Nutrition,
Год журнала:
2015,
Номер
57(13), С. 2889 - 2895
Опубликована: Ноя. 3, 2015
Turmeric
(Curcuma
longa)
is
a
type
of
herb
belonging
to
ginger
family,
which
widely
grown
in
southern
and
south
western
tropical
Asia
region.
Turmeric,
has
an
importance
place
the
cuisines
Iran,
Malesia,
India,
China,
Polynesia,
Thailand,
often
used
as
spice
effect
on
nature,
color,
taste
foods.
also
known
have
been
for
centuries
India
China
medical
treatments
illnesses
such
dermatologic
diseases,
infection,
stress,
depression.
Turmeric's
effects
health
are
generally
centered
upon
orange-yellow
colored,
lipophilic
polyphenol
substance
called
"curcumin,"
acquired
from
rhizomes
herb.
Curcumin
recently
antioxidant,
anti-inflammatory,
anticancer
and,
thanks
these
effects,
important
role
prevention
treatment
various
ranging
notably
cancer
autoimmune,
neurological,
cardiovascular
diabetic.
Furthermore,
it
aimed
increase
biological
activity
physiological
curcumin
body
by
synthesizing
analogues.
This
article
reviews
history,
chemical
physical
features,
analogues,
metabolites,
mechanisms
its
activities,
curcumin.
Abstract
Curcumin
(diferuloylmethane)
is
a
polyphenol
derived
from
the
Curcuma
longa
plant,
commonly
known
as
turmeric.
has
been
used
extensively
in
Ayurvedic
medicine
for
centuries,
it
nontoxic
and
variety
of
therapeutic
properties
including
anti-oxidant,
analgesic,
anti-inflammatory
antiseptic
activity.
More
recently
curcumin
found
to
possess
anti-cancer
activities
via
its
effect
on
biological
pathways
involved
mutagenesis,
oncogene
expression,
cell
cycle
regulation,
apoptosis,
tumorigenesis
metastasis.
shown
anti-proliferative
multiple
cancers,
an
inhibitor
transcription
factor
NF-κB
downstream
gene
products
(including
c-myc,
Bcl-2,
COX-2,
NOS,
Cyclin
D1,
TNF-α,
interleukins
MMP-9).
In
addition,
affects
growth
receptors
adhesion
molecules
tumor
growth,
angiogenesis
Head
neck
squamous
carcinoma
(HNSCC)
sixth
most
common
cancer
worldwide
treatment
protocols
include
disfiguring
surgery,
platinum-based
chemotherapy
radiation,
all
which
may
result
tremendous
patient
morbidity.
As
result,
there
significant
interest
developing
adjuvant
chemotherapies
augment
currently
available
protocols,
allow
decreased
side
effects
toxicity
without
compromising
efficacy.
one
such
potential
candidate,
this
review
presents
overview
current
vitro
vivo
data
supporting
activity
head
well
some
challenges
concerning
development
chemotherapeutic
agent.
