ACS Biomaterials Science & Engineering,
Год журнала:
2024,
Номер
10(7), С. 4093 - 4113
Опубликована: Июнь 3, 2024
Titanium
(Ti)
and
its
alloys
are
widely
used
biomaterials
in
bone
repair.
Although
these
possess
stable
properties
good
biocompatibility,
the
high
elastic
modulus
low
surface
activity
of
Ti
implants
have
often
been
associated
with
infection,
inflammation,
poor
osteogenesis.
Therefore,
there
is
an
urgent
need
to
modify
implants,
where
changes
morphology
or
coatings
loading
can
confer
specific
functions
help
them
adapt
osseointegration
formation
phase
resist
bacterial
infection.
This
further
ensure
a
healthy
microenvironment
for
regeneration
as
well
promotion
immunomodulation,
angiogenesis,
this
review,
we
evaluated
various
functional
after
modification,
both
terms
static
modifications
dynamic
response
strategies,
mainly
focusing
on
synergistic
effects
antimicrobial
activities
functionalized
osteogenic.
Finally,
current
challenges
future
perspectives
summarized
provide
innovative
effective
solutions
defect
ACS Applied Materials & Interfaces,
Год журнала:
2023,
Номер
15(12), С. 15235 - 15249
Опубликована: Март 17, 2023
Two
major
issues
are
currently
hindering
the
clinical
practice
of
titanium
dental
implants
for
lack
biological
activities:
immediate/early
loading
risks
and
peri-implantitis.
To
solve
these
issues,
it
is
urgent
to
develop
multifunctional
modified
with
effective
osteogenic
antibacterial
properties.
Zinc
oxide
nanoparticles
(ZnO
NPs)
possess
superior
activity;
however,
they
can
rapidly
release
Zn2+,
causing
cytotoxicity.
In
this
study,
a
potential
implant
modification
was
creatively
developed
as
ZnO
nanoparticle-loaded
mesoporous
TiO2
coatings
(nZnO/MTC-Ti)
via
evaporation-induced
self-assembly
method
(EISA)
one-step
spin
coating.
The
(MTCs)
regulated
synthesis
NPs
inside
nanosized
pores.
synergistic
effects
MTC
on
nZnO/MTC-Ti
not
only
controlled
long-term
steady-state
Zn2+
but
also
optimized
charge
distribution
surface.
Therefore,
cytotoxicity
resolved
without
triggering
excessive
reactive
oxygen
species
(ROS).
increased
extracellular
further
promoted
favorable
intracellular
zinc
ion
microenvironment
through
modulation
transporters
(ZIP1
ZnT1).
Owing
that,
adhesion,
proliferation,
activity
bone
mesenchymal
stem
cells
(BMSCs)
were
improved.
Additionally,
inhibited
proliferation
oral
pathogens
(Pg
Aa)
by
inducing
bacterial
ROS
production.
For
in
vivo
experiments,
different
implanted
into
alveolar
fossa
Sprague–Dawley
rats
immediately
after
tooth
extraction.
found
higher
capability
enhancing
regeneration,
antibiosis,
osseointegration
vivo.
These
findings
suggested
outstanding
performance
accelerating
inhibiting
infection,
indicating
huge
solving
peri-implantitis
implants.
Abstract
Bone
defects
are
encountered
substantially
in
clinical
practice,
and
bionic
scaffolds
represent
a
promising
solution
for
repairing
bone
defects.
However,
it
is
difficult
to
fabricate
with
structures
reconstruct
the
microenvironment
fulfill
satisfying
repair
effects.
In
this
review
article,
we
first
discuss
various
strategies
design
construction
of
promote
defect
repair,
especially
including
structural
scaffold
integration
bioactive
substances
together
application
external
stimuli.
We
then
roles
artificial
intelligence
medical
imaging
aiding
treatment.
Finally,
point
out
challenges
future
outlooks
developing
multifunctional
scaffolds,
aiming
provide
insights
improving
regeneration
efficacy
accelerating
translation.
Abstract
Immunomodulation
has
emerged
as
a
promising
strategy
for
promoting
bone
regeneration.
However,
designing
osteoimmunomodulatory
biomaterial
that
can
respond
to
mechanical
stress
in
the
unique
microenvironment
of
alveolar
under
continuous
occlusal
remains
significant
challenge.
Herein,
wireless
piezoelectric
stimulation
system,
namely,
hydrogel
incorporating
BaTiO
3
nanoparticles
(BTO
NPs),
is
successfully
developed
generate
potentials
modulating
macrophage
reprogramming.
The
reprograms
macrophages
towards
M2
phenotype,
which
subsequently
induces
osteogenic
differentiation
marrow
mesenchymal
stem
cells
(BMSCs).
RNA
sequencing
analysis
reveals
piezoelectricity‐modulated
polarization
closely
associated
with
metabolic
reprogramming,
including
increased
amino
acid
biosynthesis
and
fatty
oxidation.
composite
excellent
biocompatibility
exhibits
immunomodulatory
osteoinductive
activities.
In
rat
model
defects,
effectively
promotes
endogenous
regeneration
at
load‐bearing
sites.
piezoelectric‐driven
osteoimmunomodulation
proposed
this
study
not
only
broadens
understanding
mechanism
underlying
biomaterials
tissue
but
also
provides
new
insights
into
design
development
next‐generation
biomaterials.
Abstract
The
richened
reactive
oxygen
species
(ROS)
and
their
derived
excessive
inflammation
at
bone
injured
sites
hinder
osteogenesis
of
endosseous
Ti‐based
implants.
Herein,
anti‐oxidized
polydopamine
(PDA)
is
deposited
on
hydrothermal
growth
formed
hydroxyapatite
(HA)
nanorods
Ti
to
form
a
core‐shell
structural
nanorod‐like
array
with
HA
as
core
PDA
an
amorphous
shell
(PDA@HA),
showing
not
only
ROS
scavenging
ability
but
also
near‐infrared
(NIR)
light
photo‐thermal
effects.
PDA@HA
suppresses
based
its
certain
extent,
while
periodic
treatment
(PTT)
mild
temperature
(41
±
1
°C)
further
accelerates
the
transition
macrophages
(MΦs)
adhered
from
pro‐inflammatory
(M1)
phenotype
anti‐inflammatory
(M2)
in
vitro
vivo.
Transcriptomic
analysis
reveals
that
activation
PI3K‐Akt1
signaling
pathway
responsible
for
PTT
induced
acceleration
M1‐to‐M2
MΦs.
Acting
mesenchymal
stem
cells
(MSCs)
paracrine
cytokines
M2
macrophages,
greatly
promote
osteogenetic
functions
MSCs
thus
osteogenesis.
This
work
paves
way
employing
mildly
induce
favorable
immunomodulatory
microenvironment
provides
insights
into
underlying
immunomodulation
mechanism.
Smart Materials in Manufacturing,
Год журнала:
2022,
Номер
1, С. 100009 - 100009
Опубликована: Сен. 28, 2022
Metallic
biomaterials
are
widely
used
as
short
and
long-term
implantable
devices
by
virtue
of
their
outstanding
mechanical
properties,
such
high
load-bearing
capacity
fatigue
resistance.
Due
to
inherent
bioinertness,
potential
corrosion,
some
inferior
surface
metallic
generally
require
coating
modification
improve
function
extend
lifespan
in
the
body.
High
entropy
alloys
(HEAs)
a
novel
class
materials
that
composed
at
least
five
principal
elements
with
equiatomic
or
close-to-equiatomic
compositions.
Some
unique
properties
HEAs
for
include
excellent
corrosion
resistance,
remarkable
wear
strength/hardness,
strong
diffusion
The
on
substrates
can
be
achieved
through
different
techniques,
including
thermal
spraying,
laser
deposition,
vapor
deposition.
have
become
promising
candidate
biomedical
applications
combining
tailor-made
topography,
biocompatibility,
appropriate
chemistry,
element
composition
design.
present
article
is
thorough
review
research
using
HEAs.
Bone
tissue
defects
present
a
major
challenge
in
orthopedic
surgery.
engineering
using
multiple
versatile
bioactive
materials
is
potential
strategy
for
bone-defect
repair
and
regeneration.
Due
to
their
unique
physicochemical
mechanical
properties,
biofunctional
can
enhance
cellular
adhesion,
proliferation,
osteogenic
differentiation,
thereby
supporting
stimulating
the
formation
of
new
bone
tissue.
3D
bioprinting
physical
stimuli-responsive
strategies
have
been
employed
various
studies
on
regeneration
fabrication
desired
multifunctional
biomaterials
with
integrated
properties.
In
this
review,
applied
engineering,
emerging
techniques,
rational
manufacturing
novel
therapeutic
regenerative
functions
are
summarized.
Furthermore,
impact
differentiation
stem
cells
pathways
associated
biomaterial-induced
osteogenesis
discussed.
Advanced Healthcare Materials,
Год журнала:
2024,
Номер
13(17)
Опубликована: Янв. 13, 2024
Abstract
Biomaterials
are
defined
as
“engineered
materials”
and
include
a
range
of
natural
synthetic
products,
designed
for
their
introduction
into
interaction
with
living
tissues.
considered
prominent
tools
in
regenerative
medicine
that
support
the
restoration
tissue
defects
retain
physiologic
functionality.
Although
commonly
used
medical
field,
these
constructs
inherently
foreign
toward
host
induce
an
immune
response
at
material–tissue
interface,
body
(FBR).
A
strong
connection
between
regeneration
is
suggested,
which
appropriate
amount
macrophage
polarization
necessary
to
trigger
autologous
formation.
Recent
developments
this
field
have
led
characterization
immunomodulatory
traits
optimizes
bioactivity,
integration
biomaterials
determines
fate
regeneration.
This
review
addresses
variety
aspects
involved
steering
inflammatory
response,
including
cell
interactions,
physical
characteristics,
biochemical
cues,
metabolomics.
Harnessing
advancing
knowledge
FBR
allows
optimization
biomaterial‐based
implants,
aiming
prevent
damage
implant,
improve
regeneration,
provide
efficient
successful
vivo
implantation.
Stem Cells International,
Год журнала:
2022,
Номер
2022, С. 1 - 12
Опубликована: Июнь 18, 2022
Mesenchymal
stem
cells
(MSCs)
are
the
most
promising
multipotent
that
can
differentiate
into
osteoblasts,
chondrocytes,
and
adipocytes.
This
cellular
flexibility
contributes
to
widespread
clinical
use
of
MSCs
in
tissue
repair
regeneration.
The
immune
system
is
a
key
player
regulating
bone
remodeling.
In
recent
years,
association
between
metabolism
has
become
an
increasing
focus
interest.
Metformin,
glucose-lowering
drug,
exerts
powerful
impact
on
metabolic
signaling.
However,
whether
metformin
modulate
or
influence
milieu
by
regulation
macrophages
not
been
thoroughly
elucidated.
Herein,
we
specifically
explored
complex
interactions
human
umbilical
cord
mesenchymal
(UC-MSCs)
context
metformin.
Our
research
demonstrated
only
stimulated
osteogenesis
UC-MSCs
but
also
influenced
via
promoting
M2
reducing
M1
macrophages.
Mechanically,
found
metformin-treated
possessed
more
potent
osteoinductive
capacity
our
coculture
system.
Molecularly,
these
metformin-stimulated
facilitated
activating
PI3K/AKT/mTOR
pathway.
As
using
PI3K-specific
inhibitor
LY294002,
pathway
partly
reversed
activity
which
was
activated
Overall,
novel
illuminated
cooperative
synergistic
effects
dynamic
balance
metabolism.
Advanced Healthcare Materials,
Год журнала:
2023,
Номер
12(12)
Опубликована: Март 3, 2023
Abstract
Inspired
by
the
bionic
mineralization
theory,
organic–inorganic
composites
with
hydroxyapatite
nanorods
orderly
arranged
along
collagen
fibrils
have
attracted
extensive
attention.
Planted
an
ideal
bone
scaffold
will
contribute
greatly
to
osteogenic
microenvironment;
however,
it
remains
challenging
develop
a
biomimetic
ability
promote
intrafibrillar
and
simultaneous
regulation
of
immune
microenvironment
in
situ.
To
overcome
these
challenges,
containing
ultra‐small
particle
size
calcium
phosphate
nanocluster
(UsCCP)
is
prepared,
which
can
enhance
regeneration
through
synergetic
effect
immunomodulatory.
By
efficient
infiltration
into
fibrils,
UsCCP
released
from
achieves
mineralization.
It
also
promotes
M2‐type
polarization
macrophages,
leading
both
angiogenic
potential.
The
results
confirm
that
has
immunomodulatory
effects,
making
promising
candidate
for
regeneration.