Chemical Engineering Journal, Год журнала: 2025, Номер unknown, С. 163333 - 163333
Опубликована: Май 1, 2025
Язык: Английский
Journal of Controlled Release, Год журнала: 2024, Номер 369, С. 12 - 24
Опубликована: Март 21, 2024
Язык: Английский
Процитировано
24
Advanced Science, Год журнала: 2023, Номер 11(4)
Опубликована: Ноя. 30, 2023
Immediate and effective hemostatic treatments for complex bleeding wounds are an urgent clinical demand. Hemostatic materials with characteristics of adhesion, sealing, anti-infection, concrescence promotion have drawn growing concerns. However, pure natural multifunctional in situ ultrafast self-gelation rarely reported. In this study, a hydro-sensitive collagen/tannic acid (ColTA) powder is developed that can self-gel to form adhesive by the non-covalent crosslinking between tannic (TA) collagen (Col) liquids. The physical interactions endow ColTA instantaneous formation high adhesion at various substrate surfaces. Crucially, shows enhanced performance presence blood due electrostatic red cells, conducive sealing rapid hemostasis. biocompatible hemocompatible effectively control seal caudal vein, liver, heart, femoral arteries rats. Furthermore, low-cost ready-to-use also possesses good antibacterial inhibiting biofilm ability, efficiently regulate immune response NF-κB pathway promote wound repair, making it highly promising material great potential biomedical applications.
Язык: Английский
Процитировано
25
Journal of Controlled Release, Год журнала: 2024, Номер 368, С. 703 - 727
Опубликована: Март 19, 2024
Drug delivery platforms have gracefully emerged as an indispensable component of novel cancer chemotherapy, bestowing targeted drug distribution, elevating therapeutic effects, and reducing the burden unwanted side effects. In this context, hybrid systems artfully harnessing virtues liposomes hydrogels bring remarkable benefits, especially for localized therapy, including intensified stability, excellent amenability to hydrophobic hydrophilic medications, controlled liberation behavior, appropriate mucoadhesion mucopenetration shift. Moreover, three-dimensional biocompatible liposome-integrated hydrogel networks attracted unprecedented interest in tissue regeneration, given their tunable architecture physicochemical properties, well enhanced mechanical support. This review elucidates presents cutting-edge developments recruiting treatment regeneration.
Язык: Английский
Процитировано
16
Advanced Science, Год журнала: 2024, Номер 11(20)
Опубликована: Март 9, 2024
Abstract Inflammation‐responsive hydrogels loaded with therapeutic factors are effective biomaterials for bone tissue engineering and regenerative medicine. In this study, a matrix metalloproteinase (MMP)‐responsive injectable hydrogel is constructed by integrating an MMP‐cleavable peptide (pp) into covalent tetra‐armed poly‐(ethylene glycol) (PEG) network precise drug release upon inflammation stimulation. To establish pro‐regenerative environment, phosphatidylserine (PS) encapsulated scaffold to form the PEG‐pp‐PS network, which could be triggered MMP large amount of PS during early stage retain persistently until later repair. The found mechanically biologically adaptable complex defect area. vivo in vitro studies further demonstrated ability transform macrophages anti‐inflammatory M2 phenotype promote osteogenic differentiation, thus, resulting new regeneration. Therefore, study provides facile, safe, promising cell‐free strategy on simultaneous immunoregulation osteoinduction engineering.
Язык: Английский
Процитировано
15
Chemical Engineering Journal, Год журнала: 2024, Номер 482, С. 148937 - 148937
Опубликована: Янв. 21, 2024
Язык: Английский
Процитировано
14
Advanced Functional Materials, Год журнала: 2024, Номер 34(38)
Опубликована: Май 19, 2024
Abstract Exosomes derived from mesenchymal stem cells are an active area of research due to their therapeutic potential in treating osteoporosis. To further harness performance modulating bone resorption, equipped exosomes with osteoclast‐targeting moieties on surface as well chemokine receptor antagonists blocking osteoclast recruitment. Phosphatidylserine (PS), a membrane lipid exerting immunosuppressive and phagocytic signals, is incorporated the exosome mimetics (EMs) achieve marked affinity for precursors anti‐resorptive effects. This also aimed tackle CXCL9‐CXCR3 ligand‐receptor axis, critical signaling axis regulating precursor recruitment differentiation at resorption sites, by encapsulating chemical antagonist CXCR3, AMG487, PS‐incorporated EMs (PS‐EMs). The PS‐EMs loaded AMG487 effectively protected against loss ovariectomized mouse model. These findings demonstrate great promise nanotherapies alleviating
Язык: Английский
Процитировано
11
Journal of Controlled Release, Год журнала: 2024, Номер 372, С. 846 - 861
Опубликована: Июль 6, 2024
Язык: Английский
Процитировано
11
International Journal of Nanomedicine, Год журнала: 2023, Номер Volume 18, С. 6915 - 6940
Опубликована: Ноя. 1, 2023
Abstract: Macrophages play a crucial role in tissue homeostasis and the innate immune system. They perform essential functions such as presenting antigens, regulating cytokines, responding to inflammation. However, diseases like cancer, cardiovascular disorders, autoimmune conditions, macrophages undergo aberrant polarization, which disrupts regulation impairs their normal behavior. To address these challenges, there has been growing interest developing customized targeted drug delivery systems specifically designed for macrophage-related different anatomical locations. Nanomedicine, utilizing nanoscale systems, offers numerous advantages including improved stability, enhanced pharmacokinetics, controlled release kinetics, precise temporal delivery. These hold significant promise achieving heightened therapeutic efficacy, specificity, reduced side effects treatment approaches. This review aims explore roles of major present an overview current strategies employed macrophages. Additionally, this article critically evaluates design macrophage-targeted highlighting limitations discussing prospects rapidly evolving field. By assessing strengths weaknesses existing approaches, we can identify areas improvement refinement Keywords: macrophages, nanomedicine, delivery, tumors, disease
Язык: Английский
Процитировано
16
Computers in Biology and Medicine, Год журнала: 2023, Номер 169, С. 107867 - 107867
Опубликована: Дек. 20, 2023
Язык: Английский
Процитировано
15
Pharmaceutics, Год журнала: 2023, Номер 15(3), С. 1017 - 1017
Опубликована: Март 22, 2023
Bone regeneration is a comprehensive process that involves different stages, and various growth factors (GFs) play crucial roles in the entire process. GFs are currently widely used clinical settings to promote bone repair; however, direct application of often limited by their fast degradation short local residual time. Additionally, expensive, use may carry risks ectopic osteogenesis potential tumor formation. Nanomaterials have recently shown great promise delivering for regeneration, as they can protect fragile control release. Moreover, functional nanomaterials directly activate endogenous GFs, modulating This review provides summary latest advances using deliver exogenous regeneration. We also discuss synergistic applications along with challenges future directions need be addressed.
Язык: Английский
Процитировано
14