A Biomarker‐Responsive Nanosystem with Colon‐Targeted Delivery for Ulcerative Colitis's Detection and Treatment with Optoacoustic/NIR‐II Fluorescence Imaging DOI
Zhuo Zeng, Juan Ouyang, Lihe Sun

и другие.

Advanced Healthcare Materials, Год журнала: 2022, Номер 11(22)

Опубликована: Сен. 13, 2022

Abstract Ulcerative colitis (UC) is a prevalent idiopathic inflammatory disease which causes such complications as intestinal perforation, obstruction, and bleeding, thus deleteriously impacting people's normal work quality of life. Hence, accurate diagnosis UC crucial in terms planning optimal treatment plan. Herein, pH/reactive oxygen species (ROS) dual‐responsive nanosystem (BM@EP) developed for UC's detection therapy. BM@EP composed chromophore‐drug dyad the enteric coating. The (BOD‐XT‐DHM) synthesized by linking chromophore (BOD‐XT‐BOH) flavonoid drug (dihydromyricetin DHM) through boronate ester bond. coating includes Eudragit S100 poly(lactic‐ co ‐glycolic acid) (PLGA), former commonly employed pH‐dependent polymer excipient so to attain colon‐targeted delivery, latter has been widely used an controlled‐extended release. After oral administration, delivers into colon releases molecules being triggered alkaline pH t colon, thereafter upon stimulated overexpressed H 2 O inflamed bond broken down correspondingly DHM released therapy, simultaneously near‐infrared second window (NIR‐II) fluorescence optoacoustic imaging recovery evaluation.

Язык: Английский

Metal polyphenol network/cerium oxide artificial enzymes therapeutic nanoplatform for MRI/CT-aided intestinal inflammation management DOI

Zhichao Deng,

Wenqi Ma, Chenguang Ding

и другие.

Nano Today, Год журнала: 2023, Номер 53, С. 102044 - 102044

Опубликована: Окт. 28, 2023

Язык: Английский

Процитировано

28
Endogenous CO imaging in bacterial pneumonia with a NIR fluorescent probe DOI
Beitong Zhu, Xuejian Xing, Jungryun Kim

и другие.

Biomaterials, Год журнала: 2023, Номер 304, С. 122419 - 122419

Опубликована: Дек. 5, 2023

Язык: Английский

Процитировано

24
Combination of changeable π-conjugation and hydrophilic groups for developing water-soluble small-molecule NIR-II fluorogenic probes DOI Creative Commons
Xiaofan Zhang, Shi‐Li Shen,

Diankai Liu

и другие.

Chemical Science, Год журнала: 2023, Номер 14(11), С. 2928 - 2934

Опубликована: Янв. 1, 2023

Small-molecule probes emitting in the second near-infrared window (NIR-II) are attracting great attention because of their deep-tissue imaging ability. However, developing NIR-II fluorogenic (off-on) with good water solubility remains a challenge due to lack facile approach. Herein we first report combination changeable π-conjugation and hydrophilic groups as an effective strategy for water-soluble probes. With strategy, new fluorophores prepared, among which NIR-II-F2 NIR-II-F3 show superior stability bright fluorescence aqueous media, thus used design two leucine aminopeptidase (LAP). The excellent performance real bio-environments is demonstrated by mouse vasculatures organs NIR-II-F2, LAP drug-induced liver injury mice one enzymatic probes; however, water-insoluble dyes cannot achieve such vivo under same conditions. Our may be helpful further organic other analytes.

Язык: Английский

Процитировано

23
Metabolic Nanoregulator Remodels Gut Microenvironment for Treatment of Inflammatory Bowel Disease DOI
Ting Xu,

Xiaogang Ning,

Jiayan Wu

и другие.

ACS Nano, Год журнала: 2024, Номер 18(9), С. 7123 - 7135

Опубликована: Фев. 23, 2024

Inflammatory bowel disease (IBD) is strongly related to the occurrence of accumulation toxic reactive oxygen species (ROS), inflammation mucosa, and an imbalance intestinal microbes. However, current treatments largely focus on a single factor, yielding unsatisfactory clinical outcomes. Herein, we report biocompatible IBD-targeted metabolic nanoregulator (TMNR) that synergistically regulates cellular bacterial metabolism. The TMNR comprises melanin-gallium complex (MNR) encapsulated within thermosensitive colitis-targeting hydrogel, all composed natural FDA-approved components. confers superior broad-spectrum antioxidant properties, effectively scavenging (ROS) blocking inflammatory signaling pathways. presence Ga3+ in selectively disrupts iron metabolism pathogenic microorganisms due its structural resemblance atom. Additionally, incorporating injectable hydrogel enables targeted delivery regions, prolonging their retention time providing physical barrier function for optimizing IBD treatment efficacy. Collectively, modulates redox balance inflamed colonic epithelial tissue microorganisms, thereby eliminating restoring homeostasis against IBD. Hence, this work presents comprehensive approach precise spatiotemporal regulation microenvironmental treatment.

Язык: Английский

Процитировано

15
Nanotechnology in inflammation: cutting-edge advances in diagnostics, therapeutics and theranostics DOI Creative Commons
Yuting Liu, Ziqi Lin, Yuting Wang

и другие.

Theranostics, Год журнала: 2024, Номер 14(6), С. 2490 - 2525

Опубликована: Янв. 1, 2024

Inflammatory dysregulation is intimately associated with the occurrence and progression of many life-threatening diseases.Accurate detection timely therapeutic intervention on inflammatory are crucial for effective therapy inflammation-associated diseases.However, clinical outcomes inflammation-involved disorders still unsatisfactory.Therefore, there an urgent need to develop innovative anti-inflammatory strategies by integrating emerging technological innovations traditional therapeutics.Biomedical nanotechnology one promising fields that can potentially transform diagnosis treatment inflammation.In this review, we outline recent advances in biomedical inflammation, special attention paid nanosensors nanoprobes precise inflammation-related diseases, nanotherapeutics, as well nanotheranostics combined applications.Moreover, prospects challenges translation nanomedicines highlighted.

Язык: Английский

Процитировано

13
Ultrasound-guided drug delivery system utilizing piezocatalytic MoS2 nanomaterials for anti-inflammatory therapy DOI

Ssu-Chi Lin,

Ravindra Joshi, Anindita Ganguly

и другие.

Nano Energy, Год журнала: 2024, Номер 127, С. 109732 - 109732

Опубликована: Май 15, 2024

Язык: Английский

Процитировано

9
Aminopeptidase N Activatable Nanoprobe for Tracking Lymphatic Metastasis and Guiding Tumor Resection Surgery via Optoacoustic/NIR-II Fluorescence Dual-Mode Imaging DOI
Junjie Chen, Longqi Chen, Fang Zeng

и другие.

Analytical Chemistry, Год журнала: 2022, Номер 94(23), С. 8449 - 8457

Опубликована: Июнь 3, 2022

Lymphatic metastasis is a crucial mechanism by which the cancer cells break away from primary (original) tumor and travel to closest regional lymph node(s) ultimately other organs or parts of body, closely associated with recurrence reduced survival. Thus, tracking lymphatic realizing imaging-guided lymphoma resection surgery great significance. In this study, an activatable nanoprobe developed for precisely tumors metastatic lymphoma. The molecular probe contains tricyanofuran as electron-accepting unit (electron acceptor), xanthene electron-donating donor), alanine responsive (recognition moiety) aminopeptidase N, molecules form bovine serum albumin matrix. can respond specifically N overproduced in tumor, thereby transmuting into amino group, correspondingly activated. Strong optoacoustic NIR-II fluorescence signals emitted activated be utilized visualizing tumors. Moreover, aid three-dimensional multispectral tomography (3D MSOT) imaging accurately locate site metastasis, ultimately, both excised under guidance imaging.

Язык: Английский

Процитировано

36
Recent advances on emerging nanomaterials for diagnosis and treatment of inflammatory bowel disease DOI

Wanyue Fu,

Lingling Xu,

Z Chen

и другие.

Journal of Controlled Release, Год журнала: 2023, Номер 363, С. 149 - 179

Опубликована: Сен. 27, 2023

Язык: Английский

Процитировано

22
Dual Key‐Activated Nir‐I/II Fluorescence Probe for Monitoring Photodynamic and Photothermal Synergistic Therapy Efficacy DOI Open Access

Wen‐Xin Wang,

Jing‐Jing Chao,

Zhiqiang Wang

и другие.

Advanced Healthcare Materials, Год журнала: 2023, Номер 12(27)

Опубликована: Авг. 26, 2023

As cancer markers, hydrogen peroxide (H2 O2 ) and viscosity play an essential role in the development of tumors. Meanwhile, based on performance near-infrared (NIR) fluorescence imaging high efficiency photodynamic therapy (PDT) photothermal (PTT) synergistic therapy, it is urgent to develop a dual-key viscosity) activated probe for phototherapy. Herein, NIR-I/II named BX-B reported. In presence both H2 viscosity, signal NIR-I (810 nm) NIR-II (945 can be released. , PDT PTT effects are observed. used monitor its therapeutic cells tumor-bearing mice due increased caused by PTT. addition, tumors treated with almost completely ablated after laser irradiation therapy. This work provides reliable platform effective treatment immediate evaluation effects.

Язык: Английский

Процитировано

19
Injectable‐Hydrogel‐Based Tissue Sealant for Hemostasis, Bacteria Inhibition, and Pro‐Angiogenesis in Organ Bleeding Wounds and Therapeutic Outcome Monitoring Via NIR‐II Optical Imaging DOI
Lihe Sun, Juan Ouyang,

Zunpan She

и другие.

Advanced Healthcare Materials, Год журнала: 2024, Номер 13(12)

Опубликована: Янв. 28, 2024

Abstract Sudden hemorrhage stemming from internal organ wounds poses a grave and potentially fatal risk if left untreated. Injectable‐hydrogel‐based tissue sealants featuring multiple actions, including fit‐to‐shape in situ gelation, rapid hemostasis, pro‐angiogenic, anti‐bacterial outcome tracking, are ideal for the management of trauma wounds. Herein, an injectable‐hydrogel sealant AN@CD‐PEG&TQ which consists four‐arm 4‐arm poly(ethylene glycol) (PEG‐SC) succinimidyl carbonate), AN@CD nanoprobe, two bioactive peptides (anti‐microbial peptide Tet213 pro‐angiogenic QK) is developed. Among them, nanoparticles form through host/guest complexation amino‐group‐containing β‐cyclodextrin adamantyl group, enabling biomarker (NO)‐activatable optoacoustic/NIR‐II: Near‐infrared second biological window fluorescent imaging. The ample ─NH2 groups on surface readily engage cross‐linking with ester located at ends PEG‐SC. This expedites gelation process without necessitating additional initiators or agents; thus, significantly enhancing both hydrogel's application convenience biocompatibility. Bioactive (Tet213 safeguard against possible bacterial infections, facilitate angiogenesis, eventually, improve healing. hydrogel‐based demonstrates superior therapeutic bioimaging performance various mouse models liver hemorrhage, gastric perforation, bacterial‐infected skin wound models, highlighting its potential as high‐performance bleeding management.

Язык: Английский

Процитировано

7