Advanced Functional Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Авг. 5, 2024
Abstract
Reproductive
health
concerns
like
Mayer‐Rokitansky‐Küster‐Hauser
(MRKH)
syndrome
are
prevalent
in
today's
society.
MRKH
is
a
condition
that
severely
affects
women's
sexual
life,
fertility,
and
mental
has
high
prevalence
of
one
out
5000
female
births.
Vaginoplasty
the
primary
method
to
regain
patients’
reproductive
health.
However,
conventional
vaginoplasty
faces
various
challenges,
including
complex
non‐customized
treatment
procedures
causing
intense
pains
complications.
To
bring
new
advances
vaginoplasty,
3D‐printed
hydrogel
scaffold
developed
provide
satisfactory
mechanical
support
bioactivity
for
accelerating
defect
repair
after
surgery.
The
consisting
gelatin
methacryloyl
(gelMA)
carrageenan
(Car)
custom
using
an
ambient
temperature
printing
system.
Furthermore,
undergoes
dual‐crosslinking
through
chemical
crosslinking
gelMA
ionic
Car
with
magnesium
ions
(Mg
2+
).
This
strategy
substantially
improves
overall
properties
introduces
bioactive
Mg
.
sustained
release
plus
extracts
from
dual‐crosslinked
significantly
promotes
cell
proliferation,
migration
angiogenesis.
In
preclinical
rat
model
penetrating
genital
tract
defects
mimicking
implantation
repairs
wounds
near‐normal
levels
within
week,
showing
potential
as
alternative
better
regaining
Macromolecular Materials and Engineering,
Год журнала:
2024,
Номер
309(6)
Опубликована: Апрель 18, 2024
Abstract
The
primary
request
nowadays
is
for
innovative
and
superior
scaffold
designs
that
mimic
the
characteristics
of
native
tissue
in
cartilage
engineering.
GelMA/Alginate
(G/A)
interpenetrating
polymer
network
(IPN)
has
become
a
popular
hydrogel
material
engineering
because
its
mechanical
biological
properties.
Here,
to
balance
properties,
composed
G/A
covalent
organic
frameworks
(COF)
nanoparticles
specially
designed.
In
this
study,
GelMA/Alginate/COF
(G/A/C)
with
improved
properties
such
as
pore
size,
swelling,
strength,
shear‐thinning
behavior,
biocompatibility
produced.
Furthermore,
G/A/C
facilitate
printing
complex
three
dimensional
(3D)
scaffolds.
test
result
demonstrates
addition
COF
up
1%
(w/w)
enhances
porosity
decreases
size
(0.2
times),
improves
compression
strength
(six
degradation
ratio
(0.05
times)
swelling
(0.3
compared
sample.
Besides,
cell
viability
confirms
growth
during
incubation
great
behavior
(more
than
98%).
suitable
performance
containing
shape
fidelity
injection
by
3D
printer
confirmed.
Nanocomposite
IPN
based
on
could
be
useful
applications.
Materials & Design,
Год журнала:
2023,
Номер
227, С. 111705 - 111705
Опубликована: Фев. 6, 2023
The
reconstruction
of
large
bone
defects
by
bioactive
materials
without
exogenous
cells,
cytokines
or
growth
factors
remains
a
substantial
clinical
challenge.
Herein,
we
present
the
rational
design
injectable
and
adhesive
(GMAD/LP)
hydrogels
composed
gelatin-methacryloyl
(GelMA),
dopamine-grafted
alginate
(AD),
polydopamine-functionalized
Laponite
([email
protected])
nanosheets
that
can
act
as
osteoimmune
regulators
to
engineer
pro-regenerative
microenvironment
for
personalized
regeneration.
as-fabricated
GMAD/LP
hydrogel
with
excellent
tissue
adhesion,
self-healing,
injectability,
improved
mechanical
strength
fill
irregular
in
minimally
invasive
manner.
Moreover,
exhibited
outstanding
osteogenic
potential
osteoimmunomodulatory
functions
vitro,
significantly
promoting
proliferation,
spreading,
differentiation
mesenchymal
stem
cells
(BMSCs),
which
was
further
augmented
hydrogel-induced
macrophage
M2-phenotype
polarization
effective
M2
macrophage-BMSC
crosstalk.
In
vivo
experiments
cranial
defect
model
demonstrated
induced
reparative
similar
normal
cranium,
characterized
an
increased
percentage
anti-inflammatory
macrophages
endogenous
high-level
neovascularization,
consequently
accelerating
healing.
This
strategy
not
only
achieves
but
also
provides
feasible
methodology
recover
injured
through
integrated
diverse
functions.
Advanced Functional Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Авг. 5, 2024
Abstract
Reproductive
health
concerns
like
Mayer‐Rokitansky‐Küster‐Hauser
(MRKH)
syndrome
are
prevalent
in
today's
society.
MRKH
is
a
condition
that
severely
affects
women's
sexual
life,
fertility,
and
mental
has
high
prevalence
of
one
out
5000
female
births.
Vaginoplasty
the
primary
method
to
regain
patients’
reproductive
health.
However,
conventional
vaginoplasty
faces
various
challenges,
including
complex
non‐customized
treatment
procedures
causing
intense
pains
complications.
To
bring
new
advances
vaginoplasty,
3D‐printed
hydrogel
scaffold
developed
provide
satisfactory
mechanical
support
bioactivity
for
accelerating
defect
repair
after
surgery.
The
consisting
gelatin
methacryloyl
(gelMA)
carrageenan
(Car)
custom
using
an
ambient
temperature
printing
system.
Furthermore,
undergoes
dual‐crosslinking
through
chemical
crosslinking
gelMA
ionic
Car
with
magnesium
ions
(Mg
2+
).
This
strategy
substantially
improves
overall
properties
introduces
bioactive
Mg
.
sustained
release
plus
extracts
from
dual‐crosslinked
significantly
promotes
cell
proliferation,
migration
angiogenesis.
In
preclinical
rat
model
penetrating
genital
tract
defects
mimicking
implantation
repairs
wounds
near‐normal
levels
within
week,
showing
potential
as
alternative
better
regaining
