Research Square (Research Square),
Год журнала:
2023,
Номер
unknown
Опубликована: Май 9, 2023
Abstract
The
present
study
aimed
to
develop
a
composite
material
using
sodium
alginate
and
hydroxypropyl
methylcellulose
in
combination
with
hydroxyapatite.
was
doped
zinc
developed
into
nanocomposite
by
ionic
gelation
solvent
precipitation
methods.
prepared
characterized
scanning
electron
microscopy,
atomic
force
dynamic
light
scattering,
FTIR,
XRD
studies.
In
vivo
pharmacological
studies
were
carried
out
establish
the
bone
targeting
tissue
regeneration
efficacy
of
nanocomposite.
checked
for
cell
toxicity
performing
an
MTT
assay
MG63
line
molecular
mechanism
efficiency
assessed
silico
evaluation
method.
results
confirmed
polymeric
interlinking
successful
preparation
biodegradable
excipients.
SEM
AFM
indicated
that
within
80-200
nm
size
range.
not
cytotoxic
well
tolerated
line.
validation
docking
suggested
effectively
targeted
as
had
osteogenesis
properties
following
whereby
it
could
block
Farnesyl
Diphosphate
Synthetase
mevalonate
pathway
which
is
essential
inhibiting
osteoclastic
activity
promoting
osteogenesis.
Military Medical Research,
Год журнала:
2023,
Номер
10(1)
Опубликована: Июль 31, 2023
Most
bone-related
injuries
to
grassroots
troops
are
caused
by
training
or
accidental
injuries.
To
establish
preventive
measures
reduce
all
kinds
of
trauma
and
improve
the
combat
effectiveness
troops,
it
is
imperative
develop
new
strategies
scaffolds
promote
bone
regeneration.
Abstract
With
high
biocompatibility
and
degradability,
polysaccharide‐based
hydrogels
are
favorable
healthcare
materials.
However,
in
many
biomedical
applications,
these
materials
inconvenient
to
handle
with
fixed
morphology,
unable
closely
match
the
wounds,
easy
detach
due
insufficient
adhesion.
Inspired
by
superior
wet
adhesive
properties
of
marine
mussels,
researchers
have
used
mussel‐inspired
chemistry
create
mussel‐mimetic
injectable
that
simple
operate,
controllable
shape,
highly
adhesive,
significantly
extended
their
applications
such
as
tissue
adhesives,
delivery
vehicles,
engineering
scaffolds,
wearable
sensors.
there
few
comprehensive
reviews
on
both
adhesion
injectability,
critical
analyses
hydrogels'
preparation
methods
applications.
This
review
fills
this
gap
systematically
summarizes
strategies
for
novel
hydrogels,
including
modifying
polysaccharides
catechol‐
or
pyrogallol‐containing
small
molecules
leveraging
different
interactions
between
catechol‐/pyrogallol‐modified
other
substances
form
crosslinked
hydrogels.
Furthermore,
recent
discussed,
future
challenges
research
trends
proposed.
Materials & Design,
Год журнала:
2023,
Номер
233, С. 112268 - 112268
Опубликована: Авг. 22, 2023
The
bio-inertness
of
titanium
(Ti)
and
the
accompanying
severe
inflammation
can
extremely
inhibit
coupled
osteogenesis-angiogenesis
regulation
result
in
undesirable
osseointegration
peri-implant
during
implantation
process.
Herein,
three
types
TiO2
nanotubes
(TNT)
were
prepared
on
native
Ti
substrates
using
anodic
oxidation
approach,
including
TNT
with
a
diameter
30
nm
(TNT-30),
70
(TNT-70),
110
(TNT-110).
Among
four
substrates,
TNT-70
was
most
prominent
to
induce
differentiation
macrophages
pro-healing
M2
phenotype
via
significant
down-regulation
pro-inflammation
genes
(CD86,
iNOS,
CD11c)
cytokines
(TNF-α,
IL-6),
as
well
up-regulation
anti-inflammation
(CD206,
Arg-1,
IL-10)
(TGF-β,
IL-10).
Furthermore,
could
stimulate
osteogenic
potential
mesenchymal
stem
cells
(MSCs)
angiogenic
ability
human
umbilical
vein
endothelial
(HUVECs)
through
multiple
paracrine
signaling.
In
vivo
experiments
suggested
that
significantly
relieved
early
inflammatory
response
around
implant
facilitated
osteogenesis
angiogenesis,
effectively
promoted
peri-implant.
This
study
provided
reference
for
fabricating
surface
topography
implants
improving
relieving
associated
excessive
responses.
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(16), С. 9100 - 9100
Опубликована: Авг. 22, 2024
The
impressive
adhesive
capacity
of
marine
mussels
has
inspired
various
fascinating
designs
in
biomedical
fields.
Mussel-inspired
injectable
hydrogels,
as
a
type
promising
mussel-inspired
material,
have
attracted
much
attention
due
to
their
minimally
invasive
property
and
desirable
functions
provided
by
components.
In
recent
decades,
hydrogels
been
designed
widely
applied
numerous
rational
incorporation
catechol
groups
endows
the
with
potential
exhibit
many
properties,
including
tissue
adhesiveness
self-healing,
antimicrobial,
antioxidant
capabilities,
broadening
applications
this
review,
we
first
give
brief
introduction
adhesion
mechanism
characteristics
hydrogels.
Further,
typical
design
strategies
are
summarized.
methodologies
for
integrating
into
polymers
crosslinking
methods
discussed
section.
addition,
systematically
overview
applications,
focus
on
how
unique
properties
these
benefit
challenges
perspectives
last
This
review
may
provide
new
inspiration
novel
bioinspired
facilitate
application
