All‐Natural Immunomodulatory Bioadhesive Hydrogel Promotes Angiogenesis and Diabetic Wound Healing by Regulating Macrophage Heterogeneity

Advanced Science, Год журнала: 2023, Номер 10(13)

Опубликована: Март 2, 2023

Abstract Macrophages are highly heterogeneous and exhibit a diversity of functions phenotypes. They can be divided into pro‐inflammatory macrophages (M1) anti‐inflammatory (M2). Diabetic wounds characterized by prolonged inflammatory phase difficulty in healing due to the accumulation wound. Therefore, hydrogel dressings with macrophage heterogeneity regulation function hold great promise promoting diabetic wound clinical applications. However, precise conversion M1 M2 simple biosafe approaches is still challenge. Here, an all‐natural ability regulate developed promote angiogenesis healing. The protocatechuic aldehyde hybridized collagen‐based exhibits good bioadhesive antibacterial properties as well reactive oxygen species scavenging ability. More importantly, able convert without need for any additional ingredients or external intervention. This safe immunomodulatory approach shows application potential shortening repair accelerating

Язык: Английский

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Advances in Injectable Hydrogel Strategies for Heart Failure Treatment

Advanced Healthcare Materials, Год журнала: 2023, Номер 12(19)

Опубликована: Март 13, 2023

Heart failure (HF) affects 60 million people worldwide and has developed into a global public health problem surpassing cancer urgently needs to be solved. According the etiological spectrum, HF due myocardial infarction (MI) become dominant cause of morbidity mortality. Possible treatments include pharmacology, medical device implantation, cardiac transplantation, which are limited in their ability promote long-term functional stabilization heart. Injectable hydrogel therapy emerged as minimally invasive tissue engineering treatment approach. Hydrogels can provide necessary mechanical support for infarcted myocardium serve carriers various drugs, bioactive factors, cells improve cellular microenvironment region induce regeneration. Herein, pathophysiological mechanism is explored injectable hydrogels potential solution current clinical trials applications summarized. Specifically, hydrogels, decellularized ECM variety biotherapeutic agent-loaded conductive repair were discussed, action these hydrogel-based therapies was emphasized. Finally, limitations future prospects post MI proposed inspire novel therapeutic strategies.

Язык: Английский

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A drug-free cardiovascular stent functionalized with tailored collagen supports in-situ healing of vascular tissues

Nature Communications, Год журнала: 2024, Номер 15(1)

Опубликована: Янв. 25, 2024

Abstract Drug-eluting stent implantation suppresses the excessive proliferation of smooth muscle cells to reduce in-stent restenosis. However, efficacy drug-eluting stents remains limited due delayed reendothelialization, impaired intimal remodeling, and potentially increased late Here, we show that a drug-free coating formulation functionalized with tailored recombinant humanized type III collagen exerts one-produces-multi effects in response injured tissue following implantation. We demonstrate possesses anticoagulation, anti-inflammatory, hyperplasia suppression properties. perform transcriptome analysis indicate favors endothelialization process induces conversion contractile phenotype. find compared stents, our reduces restenosis rabbit porcine models improves vascular neointimal healing model. Collectively, system represents promising strategy for next-generation stents.

Язык: Английский

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Hydrogel-based cardiac repair and regeneration function in the treatment of myocardial infarction

Materials Today Bio, Год журнала: 2024, Номер 25, С. 100978 - 100978

Опубликована: Фев. 13, 2024

A life-threatening illness that poses a serious threat to human health is myocardial infarction. It may result in significant number of cells dying, dilated left ventricles, dysfunctional heart function, and ultimately cardiac failure. Based on the development emerging biomaterials lack clinical treatment methods donors for infarction, hydrogels with good compatibility have been gradually applied Specifically, based three processes pathophysiology we summarized various types designed tissue engineering recent years, including natural hydrogels, intelligent growth factors, stem cells, microRNA-loaded hydrogels. In addition, also describe patch preparation techniques promote repair MI function. Although most these are still preclinical research stage trials, they great potential further application future. expected this review will improve our knowledge offer fresh approaches treating

Язык: Английский

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Injectable smart stimuli-responsive hydrogels: pioneering advancements in biomedical applications

Biomaterials Science, Год журнала: 2023, Номер 12(1), С. 8 - 56

Опубликована: Окт. 25, 2023

Hydrogels have established their significance as prominent biomaterials within the realm of biomedical research. However, injectable hydrogels garnered greater attention compared with conventional counterparts due to excellent minimally invasive nature and adaptive behavior post-injection. With rapid advancement emerging chemistry deepened understanding biological processes, contemporary been endowed an "intelligent" capacity respond various endogenous/exogenous stimuli (such temperature, pH, light magnetic field). This innovation has spearheaded revolutionary transformations across fields such tissue engineering repair, controlled drug delivery, disease-responsive therapies, beyond. In this review, we comprehensively expound upon raw materials (including natural synthetic materials) principles these advanced hydrogels, concurrently providing a detailed discussion prevalent strategies for conferring stimulus responsiveness. Finally, elucidate latest applications "smart" stimuli-responsive in domain, offering insights into prospects.

Язык: Английский

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Surface Engineering of Central Venous Catheters via Combination of Antibacterial Endothelium‐Mimicking Function and Fibrinolytic Activity for Combating Blood Stream Infection and Thrombosis

Advanced Healthcare Materials, Год журнала: 2023, Номер 12(23)

Опубликована: Май 11, 2023

Abstract Long‐term blood‐contacting devices (e.g., central venous catheters, CVCs) still face the highest incidence of blood stream infection and thrombosis in clinical application. To effectively address these complications, this work reports a dual‐functional surface engineering strategy for CVCs by organic integration endothelium‐mimicking fibrinolytic functions. In proposal, lysine (Lys)/Cu 2+ ‐incorporated zwitterionic polymer coating (defined as PDA/Lys/Cu‐SB) is designed robustly fabricated onto commercial using facile two‐step process. Initially, adhesive ene ‐functionalized dopamine covalently reacted with Lys simultaneously coordinated bactericidal Cu ions, leading to deposition PDA/Lys/Cu on through mussel foot protein inspired chemistry. Next, poly(sulfobetaine methacrylate) (pSB) brushes are grafted endow lubricant antifouling properties. final PDA/Lys/Cu‐SB coating, function achieved combining catalytic generation nitric oxide from chelated pSB brushes, which led significant prevention thrombosis, bacterial vivo. Furthermore, immobilized activity show remarkably enhanced long‐term anti‐thrombogenic properties evidenced vivo demonstrating capability lyse nascent clots. Therefore, developed provides promising solution combat infection.

Язык: Английский

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Cardiac tissue engineering for myocardial infarction treatment

European Journal of Pharmaceutical Sciences, Год журнала: 2023, Номер 185, С. 106439 - 106439

Опубликована: Март 30, 2023

Myocardial infarction is one of the major causes morbidity and mortality worldwide. Current treatments can relieve symptoms myocardial ischemia but cannot repair necrotic tissue. Novel therapeutic strategies based on cellular therapy, extracellular vesicles, non-coding RNAs growth factors have been designed to restore cardiac function while inducing cardiomyocyte cycle re-entry, ensuring angiogenesis cardioprotection, preventing ventricular remodeling. However, they face low stability, cell engraftment issues or enzymatic degradation in vivo, it thus essential combine them with biomaterial-based delivery systems. Microcarriers, nanocarriers, patches injectable hydrogels yielded promising results preclinical studies, some which are currently being tested clinical trials. In this review, we cover recent advances made acellular therapies used for after MI. We present current trends tissue engineering related use microcarriers, as systems biologics. Finally, discuss most crucial aspects that should be addressed order advance towards translation approaches.

Язык: Английский

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Triptolide with hepatotoxicity and nephrotoxicity used in local delivery treatment of myocardial infarction by thermosensitive hydrogel

Journal of Nanobiotechnology, Год журнала: 2023, Номер 21(1)

Опубликована: Июль 17, 2023

Myocardial infarction (MI) resulting from coronary artery occlusion is the leading global cause of cardiovascular disability and mortality. Anti-inflammatory treatment plays an important role in MI treatment. Triptolide (TPL), as a Chinese medicine monomer, has variety biological functions, including anti-inflammatory, anti-tumor, immunoregulation. However, it been proved that TPL poorly water soluble, clear hepatotoxicity nephrotoxicity, which seriously limits its clinical application. Herein, we designed long-acting hydrogel platform (TPL@PLGA@F127) for by intramyocardial injection. First, found inflammatory response immune regulation might be main mechanisms against network pharmacology. Subsequently, prepared tested effects toxicity on normal organs early stage (3 days after MI-operation). The results showed TPL@PLGA@F127 could not only promote "repair" macrophages polarization (to M2 macrophage) day 3 MI, but also long-lasting anti-inflammatory effect later (28 Additionally, attenuate releasing more slowly stably. Finally, observed long-term improve cardiac function, depress myocardial fibrosis protect cardiomyocytes. In summary, this study indicated enhance therapeutic established strong foundation application MI.

Язык: Английский

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Biomaterials-Based Antioxidant Strategies for the Treatment of Oxidative Stress Diseases

Biomimetics, Год журнала: 2024, Номер 9(1), С. 23 - 23

Опубликована: Янв. 3, 2024

Oxidative stress is characterized by an increase in reactive oxygen species or a decrease antioxidants the body. This imbalance leads to detrimental effects, including inflammation and multiple chronic diseases, ranging from impaired wound healing highly impacting pathologies neural cardiovascular systems, bone, amongst others. However, supplying compounds with antioxidant activity hampered their low bioavailability. The development of biomaterials capacity poised overcome this roadblock. Moreover, treatment inflammation, material-based strategies would allow controlled targeted release into affected tissue. In review, we revise main causes effects oxidative stress, survey used for wounds, neurodegenerative diseases (focusing on cardiac infarction, myocardial ischemia-reperfusion injury atherosclerosis) osteoporosis. We anticipate that these developments will lead emergence new technologies tissue engineering, control prevention associated stress.

Язык: Английский

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Injectable pH Responsive Conductive Hydrogel for Intelligent Delivery of Metformin and Exosomes to Enhance Cardiac Repair after Myocardial Ischemia‐Reperfusion Injury

Advanced Science, Год журнала: 2025, Номер unknown

Опубликована: Фев. 18, 2025

Abstract Myocardial ischemia‐reperfusion injury (MIRI) is a leading cause of complications and high mortality associated with acute myocardial infarction. Injectable hydrogel emerges as promising biomaterial for repair due to their ability mimic the mechanical electrophysiological properties heart tissue. In this study, an injectable conductive developed that responds weakly acidic microenvironment ischemic injury, enabling intelligent release metformin exosomes enhance cardiac following MIRI. This multifunctional demonstrates self‐healing properties, shear‐thinning injectability, electrical conductivity, elastic modulus comparable natural myocardium, alongside excellent biocompatibility. At cellular level, system exhibits significant antioxidant, anti‐apoptotic, improvement characteristics, mitochondrial protection angiogenic effects, transcriptome sequencing revealing effective activation PI3K/AKT, VEGF, AMPK signaling pathways. vivo studies further confirm treatment reduces infarct size, fibrosis incidence arrhythmia, while improving ventricular ejection fraction facilitating restoration function after conclusion, pH‐responsive presented enables delivery exosomes, offering novel therapeutic approach enhancing treating

Язык: Английский

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