ACS Applied Materials & Interfaces,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 21, 2025
Photoimmunotherapy
has
emerged
as
a
promising
strategy
for
cancer
therapy
due
to
its
increased
therapeutic
effect,
ability
reverse
drug
resistance,
and
enhanced
immune
activation.
But
there
is
still
lack
of
effective
nanomaterial-based
photothermal
(PTT)
or
photodynamic
(PDT)
agents
in
photoimmunotherapy.
In
this
study,
photosensitizer
hematoporphyrin-modified
G5
PAMAM
(G5-HP)
nanomaterials
are
synthesized,
which
exhibit
excellent
conversion
capability
effects
under
660
nm
irradiation,
effectively
inducing
tumor
cell
ablation
immunogenic
death
(ICD).
Besides,
ICD
induced
by
G5-HP
can
generate
tumor-associated
antigens,
thereby
enhancing
dendritic
(DC)
maturation
subsequent
T
addition,
polymers
bind
Toll-like
receptor
(TLR)
agonists
CpG-ODN
through
electrostatic
interaction,
forming
stable
G5-HP/CpG
nanoparticles.
The
incorporation
an
immunoadjuvant
further
amplified
DC
maturation,
synergizing
with
phototherapy
strengthen
antitumor
immunity.
Notably,
vivo
studies
confirmed
that
nanoparticles
significantly
suppressed
colorectal
growth
laser
while
maintaining
biocompatibility.
Taken
together,
the
synthesized
perform
PTT
PDT
efficacy,
formed
integrate
DC-mediated
immunotherapy.
This
study
offers
treatment,
leveraging
synergistic
immunotherapy
achieve
superior
outcomes.
Abstract
Cancer
nanovaccines
represent
a
promising
frontier
in
cancer
immunotherapy,
utilizing
nanotechnology
to
augment
traditional
vaccine
efficacy.
This
review
comprehensively
examines
the
current
state‐of‐the‐art
nanovaccine
development,
elucidating
innovative
strategies
and
technologies
employed
their
design.
It
explores
both
preclinical
clinical
advancements,
emphasizing
key
studies
demonstrating
potential
elicit
robust
anti‐tumor
immune
responses.
The
study
encompasses
various
facets,
including
integrating
biomaterial‐based
nanocarriers
for
antigen
delivery,
adjuvant
selection,
impact
of
nanoscale
properties
on
performance.
Detailed
insights
into
complex
interplay
between
tumor
microenvironment
responses
are
provided,
highlighting
challenges
opportunities
optimizing
therapeutic
outcomes.
Additionally,
presents
thorough
analysis
ongoing
trials,
presenting
snapshot
landscape.
By
curating
latest
scientific
findings
developments,
this
aims
serve
as
comprehensive
resource
researchers
clinicians
engaged
advancing
immunotherapy.
Integrating
design
holds
immense
promise
revolutionizing
treatment
paradigms,
provides
timely
update
evolving
landscape
nanovaccines.
Acta Pharmaceutica Sinica B,
Год журнала:
2024,
Номер
14(8), С. 3432 - 3456
Опубликована: Май 13, 2024
The
advent
of
cancer
immunotherapy
has
imparted
a
transformative
impact
on
treatment
paradigms
by
harnessing
the
power
immune
system.
However,
challenge
practical
and
precise
targeting
malignant
cells
persists.
To
address
this,
engineered
nanoparticles
(NPs)
have
emerged
as
promising
solution
for
enhancing
targeted
drug
delivery
in
immunotherapeutic
interventions,
owing
to
their
small
size,
low
immunogenicity,
ease
surface
modification.
This
comprehensive
review
delves
into
contemporary
research
at
nexus
NP
engineering
immunotherapy,
encompassing
an
extensive
spectrum
morphologies
strategies
tailored
toward
optimizing
tumor
augmenting
therapeutic
effectiveness.
Moreover,
it
underscores
mechanisms
that
NPs
leverage
bypass
numerous
obstacles
encountered
regimens
probes
combined
potential
when
co-administered
with
both
established
novel
modalities.
Finally,
evaluates
existing
limitations
platforms
which
could
shape
path
future
advancements
this
field.
ACS Chemical Health & Safety,
Год журнала:
2024,
Номер
31(2), С. 153 - 161
Опубликована: Март 13, 2024
Cancer
is
one
of
the
most
prevalent
causes
mortality
worldwide.
The
arena
cancer
diagnosis
and
therapy
has
undergone
a
tremendous
revolution
since
development
nanotechnology.
Due
to
their
nanosize
biocompatibility,
nanoparticles
are
extensively
employed
for
gene
targeted
drug
delivery.
Nanotechnology-based
approaches
have
also
shown
promising
advancements
in
utilization
extracellular
vesicles
diagnosis,
prognosis,
therapy.
Apart
from
this,
CRISPR/Cas9
(Clustered
Regularly
Interspaced
Short
Palindromic
Repeats
CRISPR-associated
protein
9)-based
nanotherapy
therapeutic
nanovaccines
demonstrated
encouraging
results
revolutionizing
treatment.
molecular
imaging
contrast
agents
can
detect
at
very
early
stages,
allowing
prompt
treatment
better
patient
outcomes.
Although
offer
multiple
benefits
administration,
they
additionally
possess
certain
pharmacokinetic
limitations,
such
as
body
clearance,
restricted
tissue
penetration,
confrontation
with
biological
barriers,
biodistribution,
accumulation.
However,
improvements
nanoparticle
design
intended
resolve
safety
issues
enhance
effects
these
particles
variety
disease
complications.
While
nanotechnology
immense
potential
cancer,
there
still
several
challenges
overcome,
including
guaranteeing
nanomaterials,
taking
into
account
regulatory
issues,
creating
scalable
affordable
solutions.
Nevertheless,
new
developments
current
research
hold
promise
further
detection
International Journal of Nanomedicine,
Год журнала:
2023,
Номер
Volume 18, С. 1433 - 1468
Опубликована: Март 1, 2023
Abstract:
With
the
booming
development
of
nanomedicine,
mild
photothermal
therapy
(mPTT,
42–
45°C)
has
exhibited
promising
potential
in
tumor
therapy.
Compared
with
traditional
PTT
(>
50°C),
mPTT
less
side
effects
and
better
biological
conducive
to
treatment,
such
as
loosening
dense
structure
tissues,
enhancing
blood
perfusion,
improving
immunosuppressive
microenvironment.
However,
a
relatively
low
temperature
cannot
allow
completely
eradicate
tumors,
therefore,
substantial
efforts
have
been
conducted
optimize
application
This
review
extensively
summarizes
latest
advances
mPTT,
including
two
sections:
(1)
taking
leading
role
maximize
its
effect
by
blocking
cell
defense
mechanisms,
(2)
regarding
supporting
assist
other
therapies
achieve
synergistic
antitumor
curative
effect.
Meanwhile,
special
characteristics
imaging
capabilities
nanoplatforms
applied
various
are
discussed.
At
last,
this
paper
puts
forward
bottlenecks
challenges
current
research
path
possible
solutions
directions
future
proposed
correspondingly.
Keywords:
nanotechnology,
therapy,
Biomaterials Science,
Год журнала:
2024,
Номер
12(9), С. 2203 - 2228
Опубликована: Янв. 1, 2024
Unmethylated
cytosine-phosphate-guanine
(CpG)
oligodeoxynucleotides
(ODNs),
which
were
therapeutic
DNA
with
high
immunostimulatory
activity,
have
been
applied
in
widespread
applications
from
basic
research
to
clinics
as
agents
for
cancer
immunotherapy,
viral
infection,
allergic
diseases
and
asthma
since
their
discovery
1995.
The
major
factors
consider
clinical
translation
using
CpG
motifs
are
the
protection
of
ODNs
DNase
degradation
delivery
Toll-like
receptor-9
expressed
human
B-cells
plasmacytoid
dendritic
cells.
Therefore,
great
efforts
devoted
advances
efficient
systems
ODNs.
In
this
review,
we
outline
new
horizons
recent
developments
field,
providing
a
comprehensive
summary
nanoparticle-based
developed
improve
efficacy
CpG-mediated
immune
responses,
including
nanostructures,
inorganic
nanoparticles,
polymer
metal-organic-frameworks,
lipid-based
nanosystems,
proteins
peptides,
well
exosomes
cell
membrane
nanoparticles.
Moreover,
future
challenges
establishment
immunotherapeutic
discussed.
We
expect
that
continuously
growing
interest
development
CpG-based
immunotherapy
will
certainly
fuel
excitement
stimulation
medicine
research.
ACS Nano,
Год журнала:
2024,
Номер
18(29), С. 18801 - 18833
Опубликована: Июль 9, 2024
Tumor
vaccines,
an
important
part
of
immunotherapy,
prevent
cancer
or
kill
existing
tumor
cells
by
activating
restoring
the
body's
own
immune
system.
Currently,
various
formulations
vaccines
have
been
developed,
including
cell
membrane
DNA
mRNA
polypeptide
virus-vectored
and
tumor-in-situ
vaccines.
There
are
also
multiple
delivery
systems
for
such
as
liposomes,
vesicles,
viruses,
exosomes,
emulsions.
In
addition,
to
decrease
risk
escape
tolerance
that
may
exist
with
a
single
vaccine,
combination
therapy
radiotherapy,
chemotherapy,
checkpoint
inhibitors,
cytokines,
CAR-T
therapy,
photoimmunotherapy
is
effective
strategy.
Given
critical
role
in
here,
we
look
back
history
discuss
antigens,
adjuvants,
formulations,
systems,
mechanisms,
future
directions
Advanced Functional Materials,
Год журнала:
2024,
Номер
34(29)
Опубликована: Апрель 5, 2024
Abstract
Rapid
advances
in
nanotechnology
have
made
it
possible
to
combine
photothermal
therapy
(PTT)
with
immunotherapy,
enabling
activate
an
situ
vaccine
effect.
However,
this
effect
is
severely
impeded
by
low
antigen
presentation
level
and
highly
suppressive
tumor
immune
microenvironment
(immune
“cold”
tumors).
To
overcome
the
obstacles,
multifunctional
carrier‐free
nanoparticles
(FCDP‐NPs)
assembled
from
Fe
2+
,
toll‐like
receptor
9
agonist
(CpG),
cationic
lipid
(DOTAP)
agent
polydopamine
are
developed.
After
intratumoral
injection,
FCDP‐NPs
carrying
positive
charge
exposed
under
laser
irradiation,
which
can
capture
tumor‐associated
antigens
(TAAs)
generated
upon
post‐PTT
form
nanovaccines
(FCD‐NPs@TAAs).
The
further
promote
cross‐presentation
of
TAAs,
stimulate
adaptive
responses,
shape
“hot”
tumors.
As
a
result,
improve
survival
rates
elicit
durable
memory
that
remarkedly
prevents
metastasis,
illustrating
useful
platform
for
PTT
synergized
immunotherapy.
