Abstract
Following
the
discovery
of
bone
as
an
endocrine
organ
with
systemic
influence,
bone-brain
interaction
has
emerged
a
research
hotspot,
unveiling
complex
bidirectional
communication
between
and
brain.
Studies
indicate
that
brain
can
influence
each
other’s
homeostasis
via
multiple
pathways,
yet
there
is
dearth
systematic
reviews
in
this
area.
This
review
comprehensively
examines
interactions
across
three
key
areas:
bone-derived
factors
on
function,
effects
brain-related
diseases
or
injuries
(BRDI)
health,
concept
skeletal
interoception.
Additionally,
discusses
innovative
approaches
biomaterial
design
inspired
by
mechanisms,
aiming
to
facilitate
through
materiobiological
aid
treatment
neurodegenerative
bone-related
diseases.
Notably,
integration
artificial
intelligence
(AI)
highlighted,
showcasing
AI’s
role
expediting
formulation
effective
targeted
strategies.
In
conclusion,
offers
vital
insights
into
mechanisms
suggests
advanced
harness
these
clinical
practice.
These
offer
promising
avenues
for
preventing
treating
impacting
skeleton
brain,
underscoring
potential
interdisciplinary
enhancing
human
health.
CNS Neuroscience & Therapeutics,
Год журнала:
2024,
Номер
30(5)
Опубликована: Май 1, 2024
Abstract
Gliomas
are
the
most
common
primary
tumors
of
central
nervous
system,
with
glioblastoma
multiforme
(GBM)
having
highest
incidence,
and
their
therapeutic
efficacy
depends
primarily
on
extent
surgical
resection
postoperative
chemotherapy.
The
role
intracranial
blood–brain
barrier
occurrence
drug‐resistant
gene
O6‐methylguanine‐DNA
methyltransferase
have
greatly
limited
chemotherapeutic
agents
in
patients
GBM
made
it
difficult
to
achieve
expected
clinical
response.
In
recent
years,
rapid
development
nanotechnology
has
brought
new
hope
for
treatment
tumors.
Nanoparticles
(NPs)
shown
great
potential
tumor
therapy
due
unique
properties
such
as
light,
heat,
electromagnetic
effects,
passive
targeting.
Furthermore,
NPs
can
effectively
load
drugs,
significantly
reduce
side
effects
improve
efficacy,
showing
chemotherapy
glioma.
this
article,
we
reviewed
mechanisms
glioma
drug
resistance,
physicochemical
NPs,
advances
resistance.
We
aimed
provide
perspectives
Cancers,
Год журнала:
2024,
Номер
16(4), С. 823 - 823
Опубликована: Фев. 18, 2024
Gliomas,
the
most
prevalent
primary
malignant
brain
tumors,
present
a
challenging
prognosis
even
after
undergoing
surgery,
radiation,
and
chemotherapy.
Exosomes,
nano-sized
extracellular
vesicles
secreted
by
various
cells,
play
pivotal
role
in
glioma
progression
contribute
to
resistance
against
chemotherapy
radiotherapy
facilitating
transportation
of
biological
molecules
promoting
intercellular
communication
within
tumor
microenvironment.
Moreover,
exosomes
exhibit
remarkable
ability
traverse
blood–brain
barrier,
positioning
them
as
potent
carriers
for
therapeutic
delivery.
These
attributes
hold
promise
enhancing
diagnosis,
prognosis,
treatment.
Recent
years
have
witnessed
significant
advancements
exosome
research
realm
tumors.
In
this
article,
we
primarily
focus
on
elucidating
development,
highlighting
latest
breakthroughs
diagnostic
approaches,
outlining
prospective
directions
future
research.
Journal of Nanobiotechnology,
Год журнала:
2024,
Номер
22(1)
Опубликована: Апрель 12, 2024
Abstract
Neurodegenerative
diseases
(NDDs)
such
as
Alzheimer’s
disease,
Parkinson’s
and
amyotrophic
lateral
sclerosis
epitomize
a
class
of
insidious
relentless
neurological
conditions
that
are
difficult
to
cure.
Conventional
therapeutic
regimens
often
fail
due
the
late
onset
symptoms,
which
occurs
well
after
irreversible
neurodegeneration
has
begun.
The
integrity
blood-brain
barrier
(BBB)
further
impedes
efficacious
drug
delivery
central
nervous
system,
presenting
formidable
challenge
in
pharmacological
treatment
NDDs.
Recent
scientific
inquiries
have
shifted
focus
toward
peripheral
biological
systems,
investigating
their
influence
on
neuropathology
through
lens
extracellular
vesicles
(EVs).
These
vesicles,
distinguished
by
ability
breach
BBB,
emerging
dual
operatives
context
NDDs,
both
conveyors
pathogenic
entities
prospective
vectors
for
agents.
This
review
critically
summarizes
burgeoning
evidence
role
extracerebral
EVs,
particularly
those
originating
from
bone,
adipose
tissue,
gut
microbiota,
modulating
brain
pathophysiology.
It
underscores
duplicity
potential
EVs
modulators
disease
progression
suggests
novel
vehicles
targeted
delivery,
positing
transformative
impact
future
landscape
NDD
strategies.
Search
strategy
A
comprehensive
literature
search
was
conducted
using
PubMed,
Web
Science,
Scopus
January
2000
December
2023.
combined
following
terms
Boolean
operators:
“neurodegenerative
disease”
OR
“Alzheimer’s
“Parkinson’s
“Amyotrophic
sclerosis”
AND
“extracellular
vesicles”
“exosomes”
“outer
membrane
“drug
systems”
“blood-brain
barrier”.
MeSH
were
employed
when
searching
PubMed
refine
results.
Studies
included
if
they
published
English,
involved
human
subjects,
focused
origins
specifically
association
with
related
osteoporosis,
metabolic
syndrome,
dysbiosis.
Articles
excluded
did
not
address
NDDs
or
discuss
applications.
titles
abstracts
retrieved
articles
screened
dual-review
process
ensure
relevance
accuracy.
reference
lists
selected
also
examined
identify
additional
relevant
studies.
Parkinson's
disease
(PD)
is
currently
the
second
most
incurable
central
neurodegenerative
resulting
from
various
pathogenesis.
As
"energy
factory"
of
cells,
mitochondria
play
an
extremely
important
role
in
supporting
neuronal
signal
transmission
and
other
physiological
activities.
Mitochondrial
dysfunction
can
cause
accelerate
occurrence
progression
PD.
How
to
effectively
prevent
suppress
mitochondrial
disorders
a
key
strategy
for
treatment
PD
root.
Therefore,
emerging
mitochondria-targeted
therapy
has
attracted
considerable
interest.
Herein,
relationship
between
PD,
causes
results
dysfunction,
major
strategies
ameliorating
treat
are
systematically
reviewed.
The
study
also
prospects
main
challenges
Frontiers in Oncology,
Год журнала:
2024,
Номер
14
Опубликована: Фев. 23, 2024
Gastrointestinal
(GI)
tumors
are
a
significant
global
health
threat,
with
high
rates
of
morbidity
and
mortality.
Exosomes
contain
various
biologically
active
molecules
like
nucleic
acids,
proteins,
lipids
can
serve
as
messengers
for
intercellular
communication.
They
play
critical
roles
in
the
exchange
information
between
tumor
cells
microenvironment
(TME).
The
TME
consists
mesenchymal
components
extracellular
matrix
(ECM),
fibroblasts
being
most
abundant
cell
type
mesenchyme.
Cancer-associated
(CAFs)
derived
from
normal
stem
that
activated
TME.
CAFs
secrete
exosomes
to
modulate
proliferation,
invasion,
migration,
drug
resistance,
other
biological
processes
tumors.
Additionally,
manipulate
function
behavior
through
direct
cell-cell
interactions.
This
review
provides
summary
crosstalk
GI
exosomes,
along
potential
underlying
mechanisms.
International Journal of Nanomedicine,
Год журнала:
2024,
Номер
Volume 19, С. 3657 - 3675
Опубликована: Апрель 1, 2024
Abstract:
Exosomes
are
extracellular
vesicles
that
originate
from
various
cells
and
mediate
intercellular
communication,
altering
the
behavior
or
fate
of
recipient
cells.
They
carry
diverse
macromolecules,
such
as
lipids,
proteins,
carbohydrates,
nucleic
acids.
Environmental
stressors
can
change
exosomal
contents
many
cells,
making
them
useful
for
diagnosing
chronic
disorders,
especially
neurodegenerative,
cardiovascular,
cancerous,
diabetic
diseases.
Moreover,
exosomes
be
engineered
therapeutic
agents
to
modulate
disease
processes.
State-of-art
techniques
employed
separate
including
ultracentrifugation,
size-exclusion
chromatography
immunoaffinity.
However,
modern
technologies
aqueous
two-phase
system
well
microfluidics
gaining
attention
in
recent
years.
The
article
highlighted
composition,
biogenesis,
implications
exosomes,
standard
novel
methods
isolating
applying
biomarkers
cargo
carriers.
Keywords:
Exosomes,
vesicles,
biomarkers,
carriers,
separation
Clinical and Translational Medicine,
Год журнала:
2025,
Номер
15(1)
Опубликована: Янв. 1, 2025
Abstract
Background
The
increased
incidence
of
androgenic
alopecia
(AGA)
causes
adverse
physiological
and
psychological
effects
on
people
all
genders.
hair
follicle
stem
cells
(HFSCs)
have
displayed
clinical
improvements
AGA.
However,
the
molecular
mechanism
HFSCs
against
AGA
remains
elusive.
Methods
expression
prognosis
lncRNA
AC010789.1
in
tissues
were
assessed
by
qRT‐PCR
analysis.
CCK‐8,
EdU
Transwell
analysis
utilized
to
assess
cell
growth.
specific
binding
between
FTO
mediated
m
6
A
modification
or
effect
hnRNPA2B1,
S100A8
Wnt/β‐catenin
signaling
was
confirmed
bioinformatic
analysis,
RIP,
RNA
pull‐down
Western
blot
assay.
Exosome‐loaded
prompted
proliferation
regeneration
hairless
mice.
Results
We
herein
found
that
mRNA
levels
decreased
tissue
samples
but
surrounding
normal
samples.
Overexpression
(OE)
promoted
HFSC
proliferation,
DNA
synthesis
migration
as
well
K6HF
Lgr5
upregulation,
whereas
knockdown
showed
opposite
effects.
total
reduced
demethylase
upregulated
samples,
these
indicated
reverse
results
OE
its
abolished
AC010789.1‐induced
proliferation.
In
addition,
identified
bind
reader
which
downregulated
hnRNPA2B1
attenuated
knockdown‐induced
inhibition
Moreover,
could
enhance
downstream
protein
expression,
accelerate
Conclusions
Our
findings
demonstrated
exosome‐derived
modified
facilitated
human
activating
S100A8/Wnt/β‐catenin
signaling.
Key
points
Long
non‐coding
(lncRNA)
from
(HFSCs).
LncRNA
HFSCs.
FTO/hnRNPA2B1‐mediated
growth
signalling.
Exosome‐derived
accelerated
