Biocompatible nanoparticles self-assembled by PEGylated polyphosphoesters for combination of photodynamic therapy and hypoxia-activated chemotherapy against breast cancer DOI Creative Commons

Fengyu Wang,

Xiaojing Zou,

Chunyang Sun

и другие.

Frontiers in Pharmacology, Год журнала: 2024, Номер 15

Опубликована: Дек. 23, 2024

Introduction Although photodynamic therapy (PDT) shows considerable potential for cancer treatment due to its precise spatial control and reduced toxicity, effectively eliminating residual cells under hypoxic conditions remains challenging because of the resistance conferred by these cells. Methods Herein, we synthesize an amphiphilic PEGylated polyphosphoester present a nanocarrier (NP CT ) specifically designed codelivery hydrophobic photosensitizer (chlorin e6, Ce6) hypoxia-activated prodrugs (tirapazamine, TPZ). We investigate antitumor effect NP on both cellular animal level. Results The efficient encapsulation Ce6 TPZ enables prolonged blood circulation improved tumor distribution agents. Upon internalization tumoral cells, 660 nm laser irradiation activates Ce6, leading generation reactive oxygen species (ROS) that kill murine 4T1 breast Meanwhile, PDT process consumes large amount generate microenvironment liberated from . resulting highly cytotoxic radicals target induce cytotoxicity in remaining Compared other groups, combination resulted most substantial growth inhibition. Discussion This innovative approach provides new avenues development advanced delivery systems based polyphosphoesters therapeutic strategies.

Язык: Английский

Hydrogel-based platforms for site-specific doxorubicin release in cancer therapy DOI Creative Commons
Chunbao Zang, Yu Tian, Yujing Tang

и другие.

Journal of Translational Medicine, Год журнала: 2024, Номер 22(1)

Опубликована: Сен. 30, 2024

Язык: Английский

Процитировано

12
Intracellular Magnetic Hyperthermia Enables Concurrent Down-Regulation of CD47 and SIRPα To Potentiate Antitumor Immunity DOI
Siyao Wang,

Wangbo Jiao,

Bin Yan

и другие.

Nano Letters, Год журнала: 2024, Номер 24(9), С. 2894 - 2903

Опубликована: Фев. 26, 2024

Harnessing the potential of tumor-associated macrophages (TAMs) to engulf tumor cells offers promising avenues for cancer therapy. Targeting phagocytosis checkpoints, particularly CD47-signal regulatory protein α (SIRPα) axis, is crucial modulating TAM activity. However, single checkpoint inhibition has shown a limited efficacy. In this study, we demonstrate that ferrimagnetic vortex-domain iron oxide (FVIO) nanoring-mediated magnetic hyperthermia effectively suppresses expression CD47 on Hepa1-6 and SIRPα receptor macrophages, which disrupts CD47-SIRPα interaction. FVIO-mediated also induces immunogenic cell death polarizes TAMs toward M1 phenotype. These changes collectively bolster phagocytic ability eliminate cells. Furthermore, concurrently escalates cytotoxic T lymphocyte levels diminishes levels. Our findings reveal novel approach dual down-regulation SIRPα, reshaping microenvironment stimulate immune responses, culminating in significant antitumor

Язык: Английский

Процитировано

9
Optimization of lipid assisted polymeric nanoparticles for siRNA delivery and cancer immunotherapy DOI

Song Lin,

Houjin Jing,

Xiao‐Jiao Du

и другие.

Biomaterials Science, Год журнала: 2024, Номер 12(8), С. 2057 - 2066

Опубликована: Янв. 1, 2024

A siRNA delivery system was developed using clinically approved mPEG- b -PLGA, cationic lipid and ionizable for cancer immunotherapy.

Язык: Английский

Процитировано

8
Nanoparticle-mediated immunogenic cell death for cancer immunotherapy DOI

Haolong Qi,

Yuan Li,

Yingjie Geng

и другие.

International Journal of Pharmaceutics, Год журнала: 2024, Номер 656, С. 124045 - 124045

Опубликована: Март 30, 2024

Язык: Английский

Процитировано

7
Multifunctional ZnO@DOX/ICG-LMHP Nanoparticles for Synergistic Multimodal Antitumor Activity DOI Creative Commons
Zhuoyue Li, Jingru Wang, Junwei Liu

и другие.

Journal of Functional Biomaterials, Год журнала: 2024, Номер 15(2), С. 35 - 35

Опубликована: Янв. 30, 2024

Multifunctional nanoparticles are of significant importance for synergistic multimodal antitumor activity. Herein, zinc oxide (ZnO) was used as pH-sensitive loading the chemotherapy agent doxorubicin (DOX) and photosensitizer indocyanine green (ICG), biocompatible low-molecular-weight heparin (LMHP) gatekeepers photothermal therapy/photodynamic therapy/chemotherapy/immunotherapy. ZnO decomposed into cytotoxic Zn2+ ions, leading to a tumor-specific release ICG DOX. simultaneously produced oxygen (O2) reactive species (ROS) photodynamic therapy (PDT). The released under laser irradiation ROS PDT raised tumor temperature (PTT). DOX directly caused cell death chemotherapy. Both also induced immunogenic (ICD) immunotherapy. in vivo vitro results presented superior inhibition progression, metastasis recurrence. Therefore, this study could provide an efficient approach designing multifunctional therapy.

Язык: Английский

Процитировано

6
Surface Engineering Enhances Vanadium Carbide MXene‐Based Nanoplatform Triggered by NIR‐II for Cancer Theranostics DOI
Xiaodong Zhu,

Xide Zhang,

Jiahao Guo

и другие.

Small, Год журнала: 2024, Номер 20(44)

Опубликована: Июль 5, 2024

Despite the advantages of high tissue penetration depth, selectivity, and non-invasiveness photothermal therapy for cancer treatment, developing NIR-II agents with desirable performance advanced theranostics ability remains a key challenge. Herein, universal surface modification strategy is proposed to effectively improve vanadium carbide MXene nanosheets (L-V

Язык: Английский

Процитировано

5
Hydrophobization of Ribonucleic Acids for Facile Systemic Delivery and Multifaceted Cancer Immunotherapy DOI
Yuxi Zhang, Chaoran Chen, Miao Su

и другие.

Nano Letters, Год журнала: 2024, Номер 24(4), С. 1376 - 1384

Опубликована: Янв. 17, 2024

Ribonucleic acids (RNAs) enable disease-related gene inhibition, expression, and editing represent promising therapeutics in various diseases. The efficacy of RNA relies heavily on the presence a secure effective delivery system. Herein, we found that could be hydrophobized by cationic lipid ionizable conveniently coassemble with amphiphilic polymer to achieve micelle-like nanoparticles (MNP). results study indicate MNP exhibits high level efficiency delivering RNA. Besides, encapsulating siRNA targets CD47 PD-L1 remarkably blocked these immune checkpoints melanoma tumor model elicited robust response. Moreover, mRNA OVA achieved antigen translation presentation, leading an antitumor immunoprophylaxis outcome against OVA-expressing model. Our findings suggest hydrophobization serve as viable approach for RNA, thereby facilitating exploration therapy disease treatment.

Язык: Английский

Процитировано

4
Advances and Mechanisms of RNA–Ligand Interaction Predictions DOI Creative Commons
Zhuo Chen, Chengwei Zeng,

Haoquan Liu

и другие.

Life, Год журнала: 2025, Номер 15(1), С. 104 - 104

Опубликована: Янв. 15, 2025

The diversity and complexity of RNA include sequence, secondary structure, tertiary structure characteristics. These elements are crucial for RNA's specific recognition other molecules. With advancements in biotechnology, RNA-ligand structures allow researchers to utilize experimental data uncover the mechanisms complex interactions. However, determining these complexes experimentally can be technically challenging often results low-resolution data. Many machine learning computational approaches have recently emerged learn multiscale-level features predict Predicting interactions remains an unexplored area. Therefore, studying is essential understanding biological processes. In this review, we analyze interaction characteristics by examining structure. Our goal clarify how specifically recognizes ligands. Additionally, systematically discuss methods predicting guide future research directions. We aim inspire creation more reliable prediction tools.

Язык: Английский

Процитировано

0
An Integrated Janus Patch with Asymmetric Tissue Adhesion for Enhanced Postoperative Adhesion Prevention DOI Creative Commons
Xiaoping Tan, Xing Hu, Xiaoyu Pan

и другие.

Polymer science & technology., Год журнала: 2025, Номер unknown

Опубликована: Апрель 10, 2025

Язык: Английский

Процитировано

0
A Metformin-Based Multifunctional Nanoplatform as a DNA Damage Amplifier for Maximized Radio-Immunotherapy to Overcome Radiotherapy Resistance DOI

Shuangyan He,

Yun Huang, Jia Liu

и другие.

ACS Nano, Год журнала: 2025, Номер unknown

Опубликована: Апрель 10, 2025

Radiotherapy (RT) has been highlighted to be an effective strategy for antitumor immunity activation by causing direct DNA damages, but it generally suffers from low response rates due the compromised cytosolic (cDNA) recognition cyclic GMP-AMP synthase (cGAS). Simultaneous repair and clearance system regulation enhanced cDNA accumulation is a useful approach improve immune rates, which remains seldom reported our knowledge. Here, we report construction of metformin (MET)-based multifunctional nanocomplex, CS-MET/siTREX1 (CSMT), consisting biguanide-decorated CS (CS-MET) as vector 3'-5' exonuclease TREX1 siRNA (siTREX1) therapeutic gene RT-induced enhancement amplifying initial damage signals. The uniqueness this study development CSMT specific amplifier promote maximizing radio-immunotherapy circumventing RT resistance. Specifically, nanocomplexes show not only transfection efficiency MET modification also synergistic effects including MET's inhibition on siTREX1's attenuation clearance, leads greatest inhibitory effect in Hepa1-6 proximal/distal tumor model with high growth (TGI) value 99.1% primary significantly distal inducing immunogenic cell death (ICD), promoting tumor-associated neutrophil (TAN) polarization, stimulating tumor-specific memory T-cell generation. Overall, developed herein hold great translatable promises overcoming resistance clinics.

Язык: Английский

Процитировано

0