Advancements in zinc oxide nanomaterials: Synthesis, properties, and diverse applications
Nano-Structures & Nano-Objects,
Год журнала:
2024,
Номер
39, С. 101271 - 101271
Опубликована: Июль 24, 2024
Язык: Английский
Folate-Modified pH and ROS Dual-Responsive Polymeric Nanocarriers for Targeted Anticancer Drug Delivery
ACS Applied Nano Materials,
Год журнала:
2024,
Номер
7(7), С. 7289 - 7299
Опубликована: Март 28, 2024
The
tumor
microenvironment
is
distinguished
from
normal
tissues,
such
as
the
acidic
microenvironment,
elevated
reactive
oxygen
species
(ROS)
levels,
and
overexpressed
specific
receptors
on
cell
surface.
According
to
these
unique
hallmarks
of
cancer,
stimulus-responsive
drug
carriers
can
be
designed
for
targeted
anticancer
delivery
release
in
tissues.
Herein,
a
folate-modified
pH/ROS
dual-responsive
polymeric
micellar
nanosystem
was
developed
doxorubicin
(DOX).
profile
suggested
sustained
micelles
an
accelerated
at
lower
pH
higher
ROS
levels.
cellular
uptake
assay
indicated
that
were
internalized
by
HepG2
cells
enhanced
folate
modification
through
receptor-mediated
endocytosis
pathway.
Furthermore,
nanocarriers
demonstrated
inhibition
migration
scratch
test
showed
improved
suppression
proliferation
IC50
than
nonfolate
viability
test,
indicating
desirable
vitro
efficiency
nanosystem.
Язык: Английский
Zinc oxide nanoparticles with catalase-like nanozyme activity and near-infrared light response: A combination of effective photodynamic therapy, autophagy, ferroptosis, and antitumor immunity
Acta Pharmaceutica Sinica B,
Год журнала:
2024,
Номер
14(10), С. 4493 - 4508
Опубликована: Июль 6, 2024
We
prepared
biocompatible
and
environment-friendly
zinc
oxide
nanoparticles
(ZnO
NPs)
with
upconversion
properties
catalase-like
nanozyme
activity.
Photodynamic
therapy
(PDT)
application
is
severely
limited
by
the
poor
penetration
of
UV-Visible
light
a
hypoxic
tumor
environment.
Here,
we
used
ZnO
NPs
as
carrier
for
photosensitizer
chlorin
e6
(Ce6)
to
construct
oxide-chlorin
(ZnO-Ce6
NPs),
simultaneously
addressing
both
problems.
In
terms
penetration,
convert
808
nm
near-infrared
into
401
visible
excite
Ce6,
achieving
deep-penetrating
photodynamic
under
long-wavelength
light.
Interestingly,
ability
emit
short-wavelength
usually
observed
in
nanoparticles.
As
nanozymes,
can
catalyze
decomposition
hydrogen
peroxide
tumors,
providing
oxygen
action
relieving
hypoxia.
The
enhanced
produces
large
amount
reactive
species,
which
overactivate
autophagy
trigger
immunogenic
cell
death
(ICD),
leading
antitumor
immunotherapy.
addition,
even
absence
light,
ZnO-Ce6
induce
ferroptosis
cells
exert
effects.
Язык: Английский
Self-Assembled Nanocomposite DOX/TPOR4@CB[7]4 for Enhanced Synergistic Photodynamic Therapy and Chemotherapy in Neuroblastoma
Pharmaceutics,
Год журнала:
2024,
Номер
16(6), С. 822 - 822
Опубликована: Июнь 18, 2024
DOX/TPOR4@CB[7]4
was
synthesized
via
self-assembly,
and
its
physicochemical
properties
ability
to
generate
reactive
oxygen
species
(ROS)
were
evaluated.
The
impact
of
photodynamic
therapy
on
SH-SY5Y
cells
assessed
using
the
MTT
assay,
while
flow
cytometry
analysis
employed
detect
cell
apoptosis.
Confocal
laser
scanning
microscopy
utilized
observe
intracellular
distribution
in
cells.
Additionally,
fluorescence
imaging
nude
mice
bearing
tumors
examination
combined
effects
chemical
therapies
conducted.
incorporation
CB[7]
significantly
enhanced
optical
DOX/TPOR4@CB[7]4,
resulting
increased
ROS
production
pronounced
toxicity
towards
Moreover,
both
apoptotic
mortality
rates
exhibited
significant
elevation.
In
vivo
experiments
demonstrated
that
tumor
growth
inhibition
most
prominent
group.
π–π
interactions
facilitated
binding
between
DOX
photosensitizer
TPOR,
with
TPOR’s
naphthalene
hydrophilic
groups
encapsulated
within
CB[7]’s
cavity
through
host–guest
CB[7].
Therefore,
can
serve
as
a
nanocarrier
enhance
application
therapy,
thereby
improving
treatment
efficacy
against
neuroblastoma
tumors.
Язык: Английский
Micro-Surgeons and Nano-Pharmacists: The Future of Healthcare with Medical Nanorobots
Journal of Drug Delivery Science and Technology,
Год журнала:
2024,
Номер
unknown, С. 106410 - 106410
Опубликована: Ноя. 1, 2024
Язык: Английский
Improving the Anti-Tumor Effect of Indoleamine 2,3-Dioxygenase Inhibitor CY1-4 by CY1-4 Nano-Skeleton Drug Delivery System
Journal of Functional Biomaterials,
Год журнала:
2024,
Номер
15(12), С. 372 - 372
Опубликована: Дек. 9, 2024
CY1-4,
9-nitropyridine
[2',3':4,5]
pyrimido
[1,2-α]
indole
-5,11-
dione,
is
an
indoleamine
2,3-dioxygenase
(IDO)
inhibitor
and
a
poorly
water-soluble
substance.
It
very
important
to
increase
the
solubility
of
CY1-4
improve
its
bioavailability
therapeutic
effect.
In
this
study,
mesoporous
silica
nano-skeleton
carrier
material
Sylysia
was
selected
as
load
then
drug
delivery
system
(MSNM@CY1-4)
prepared
by
coating
hydrophilic
polymer
Hydroxypropyl
methylcellulose
(HPMC)
lipid
Distearoylphosphatidyl-ethanolamine-poly(ethylene
glycol)
Язык: Английский