International Journal of Nanomedicine, Год журнала: 2024, Номер Volume 19, С. 11671 - 11688
Опубликована: Ноя. 1, 2024
Melanoma is a highly aggressive and dangerous malignant skin tumor there an urgent need to develop effective therapeutic approaches against melanoma. The main objective of this study was construct multifunctional nanomedicine (GNR@PEG-Qu) investigate its effect on melanoma from the oxidative stress pathway.
Язык: Английский
Cancer Nanotechnology, Год журнала: 2024, Номер 15(1)
Опубликована: Авг. 21, 2024
Triple-negative breast cancer (TNBC) is an aggressive subtype of cancer. Radiation therapy (RT) a modality for TNBC management. Radiosensitizers can mitigate the adverse effects RT. Applying green-synthesized silver nanoparticles (Ag-NPs) from biological sources such as plants potential strategy to sensitize cells radiotherapy due low toxicity. Therefore, identifying novel natural synthesizing stable and broadly applicable green-Ag-NPs has gained more attention in therapy. In present study, we synthesized green- Ag-NPs pumpkin peel extract elucidated impact radiosensitizer MDA-MB 231 (a model TNBC). The prepared had spherical shape with average size 81 nm zeta − 9.96 mV. Combination RT exhibited synergistic anticancer optimum combination index (CI) 0.49 MDA-MB-231 cells. Green-synthesized synergistically potentiated RT-induced apoptosis compared corresponding monotherapies. Morphological features were further confirmed by DAPI–TUNEL staining assay. HIF-1α expression was decreased subjected Bax p53 increased, whereas Bcl-2 genes decreased. significantly increased protein level PERK CHOP while decreasing cyclin D1 p-ERK/total ERK levels These findings indicate effect treatment.
Язык: Английский
Процитировано
29
International Journal of Biological Macromolecules, Год журнала: 2025, Номер 301, С. 140144 - 140144
Опубликована: Янв. 21, 2025
Язык: Английский
Процитировано
1
Functional & Integrative Genomics, Год журнала: 2025, Номер 25(1)
Опубликована: Фев. 15, 2025
Colon cancer (CC) is a common malignancy with rising incidence worldwide. Despite advances in treatment strategies, many patients still face poor prognosis due to the development of drug resistance. Long non-coding RNAs (lncRNAs) have emerged as important regulators various biological processes and been implicated progression. Among them, colorectal neoplasia differentially expressed (CRNDE) has drawn attention for its potential roles different cancers. However, specific functions CC remain unclear. In this study, we identified CRNDE highly CC, contributing tumor progression Mechanically, regulated by transcription factor TFAP2A. Additionally, inhibits pyroptosis, form programmed cell death, promoting ubiquitin-mediated degradation RIPK3, thereby reducing sensitivity cells 5-fluorouracil (5-FU). Our findings suggest that TFAP2A/CRNDE/RIPK3 axis plays critical colon chemoresistance, highlighting therapeutic targets improving outcomes.
Язык: Английский
Процитировано
0
International Journal of Biological Macromolecules, Год журнала: 2025, Номер 306, С. 141235 - 141235
Опубликована: Фев. 21, 2025
Язык: Английский
Процитировано
0
International Journal of Nanomedicine, Год журнала: 2025, Номер Volume 20, С. 1367 - 1382
Опубликована: Фев. 1, 2025
Abstract: Breast cancer remains a significant therapeutic challenge, with the immune microenvironment playing crucial role in its progression and treatment response. This review investigates potential of nanoparticles to modulate breast therapy. Initially, we discuss composition influence on cancer, followed by current strategies targeting these components. We then provide for cells such as macrophages, dendritic cells, T-cells. The enhancing checkpoint blockade (ICB) their application vaccines is also examined. Additionally, explore synergistic effects combining conventional therapies. addresses challenges clinical translation, focusing safety, biocompatibility, toxicity. Finally, outline future research directions advancements nanoparticle-based immunotherapy, emphasizing transformative impact treatment. Keywords: nanoparticle,
Язык: Английский
Процитировано
0
Molecules and Cells, Год журнала: 2025, Номер unknown, С. 100199 - 100199
Опубликована: Фев. 1, 2025
Язык: Английский
Процитировано
0
Biomolecules, Год журнала: 2025, Номер 15(4), С. 549 - 549
Опубликована: Апрель 9, 2025
Necroptosis, a distinct form of regulated necrosis implicated in various human pathologies, is orchestrated through sophisticated signaling pathways. During this process, cells undergoing necroptosis exhibit characteristic necrotic morphology and provoke substantial inflammatory responses. Post-translational modifications (PTMs)—chemical alterations occurring after protein synthesis that critically regulate functionality—constitute essential regulatory components within these complex cascades. This intricate crosstalk between necroptotic pathways PTM networks presents promising therapeutic opportunities. Our comprehensive review systematically analyzes the molecular mechanisms underlying necroptosis, with particular emphasis on roles PTMs signal transduction. Through systematic evaluation key including ubiquitination, phosphorylation, glycosylation, methylation, acetylation, disulfide bond formation, caspase cleavage, nitrosylation, SUMOylation, we examine potential applications targeting disease pathogenesis. Furthermore, synthesize current pharmacological strategies for manipulating PTM-regulated offering novel perspectives clinical target development intervention.
Язык: Английский
Процитировано
0
Biomacromolecules, Год журнала: 2025, Номер unknown
Опубликована: Апрель 10, 2025
Tumor immunotherapy has shown considerable therapeutic potential, especially when combined with chemotherapy. In this study, we developed a multifunctional nanoplatform GNPs-DOX/R848 that and chemotherapy for the treatment of melanoma, in which gelatin nanoparticles (GNPs) were loaded immunomodulatory agent resiquimod (R848) drug doxorubicin (DOX). GNPs possessed inherent properties; R848, they induced more pronounced polarization M1-like macrophages by activating NF-κB signaling pathway, thereby reversing immunosuppressive tumor microenvironment. Meanwhile, effectively delivered R848 DOX to cells, promoting stronger effects drugs, strongly immunogenic cell death triggered DOX, leading infiltration T cells into tissue. The melanoma demonstrated significantly reduced volume, enhanced chemotherapy, providing new approach cancer
Язык: Английский
Процитировано
0
Chemical Engineering Journal, Год журнала: 2024, Номер 498, С. 155035 - 155035
Опубликована: Авг. 23, 2024
Язык: Английский
Процитировано
2
International Journal of Biological Macromolecules, Год журнала: 2024, Номер 281, С. 136243 - 136243
Опубликована: Окт. 9, 2024
Язык: Английский
Процитировано
2