A Multifunctional Low-Temperature Photothermal Nanomedicine for Melanoma Treatment via the Oxidative Stress Pathway Therapy DOI Creative Commons

Dou Zhang,

Xuyi Liu, Li Xiong

et al.

International Journal of Nanomedicine, Journal Year: 2024, Volume and Issue: Volume 19, P. 11671 - 11688

Published: Nov. 1, 2024

Melanoma is a highly aggressive and dangerous malignant skin tumor there an urgent need to develop effective therapeutic approaches against melanoma. The main objective of this study was construct multifunctional nanomedicine (GNR@PEG-Qu) investigate its effect on melanoma from the oxidative stress pathway.

Language: Английский

Green-synthesized silver nanoparticles from peel extract of pumpkin as a potent radiosensitizer against triple-negative breast cancer (TNBC) DOI Creative Commons
Soheila Montazersaheb, Aziz Eftekhari,

Amir Shafaroodi

et al.

Cancer Nanotechnology, Journal Year: 2024, Volume and Issue: 15(1)

Published: Aug. 21, 2024

Triple-negative breast cancer (TNBC) is an aggressive subtype of cancer. Radiation therapy (RT) a modality for TNBC management. Radiosensitizers can mitigate the adverse effects RT. Applying green-synthesized silver nanoparticles (Ag-NPs) from biological sources such as plants potential strategy to sensitize cells radiotherapy due low toxicity. Therefore, identifying novel natural synthesizing stable and broadly applicable green-Ag-NPs has gained more attention in therapy. In present study, we synthesized green- Ag-NPs pumpkin peel extract elucidated impact radiosensitizer MDA-MB 231 (a model TNBC). The prepared had spherical shape with average size 81 nm zeta − 9.96 mV. Combination RT exhibited synergistic anticancer optimum combination index (CI) 0.49 MDA-MB-231 cells. Green-synthesized synergistically potentiated RT-induced apoptosis compared corresponding monotherapies. Morphological features were further confirmed by DAPI–TUNEL staining assay. HIF-1α expression was decreased subjected Bax p53 increased, whereas Bcl-2 genes decreased. significantly increased protein level PERK CHOP while decreasing cyclin D1 p-ERK/total ERK levels These findings indicate effect treatment.

Language: Английский

Citations

29
Chitosan and hyaluronic acid in breast cancer treatment: Anticancer efficacy and nanoparticle and hydrogel development DOI
Yanlin Jiang, Yu Cao, Yiqun Yao

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 301, P. 140144 - 140144

Published: Jan. 21, 2025

Language: Английский

Citations

1
Nanoparticles Modulating the Immune Microenvironment in Breast Cancer Treatment DOI Creative Commons
Lijuan Guo, Jinsheng Wu,

Weifeng Lu

et al.

International Journal of Nanomedicine, Journal Year: 2025, Volume and Issue: Volume 20, P. 1367 - 1382

Published: Feb. 1, 2025

Abstract: Breast cancer remains a significant therapeutic challenge, with the immune microenvironment playing crucial role in its progression and treatment response. This review investigates potential of nanoparticles to modulate breast therapy. Initially, we discuss composition influence on cancer, followed by current strategies targeting these components. We then provide for cells such as macrophages, dendritic cells, T-cells. The enhancing checkpoint blockade (ICB) their application vaccines is also examined. Additionally, explore synergistic effects combining conventional therapies. addresses challenges clinical translation, focusing safety, biocompatibility, toxicity. Finally, outline future research directions advancements nanoparticle-based immunotherapy, emphasizing transformative impact treatment. Keywords: nanoparticle,

Language: Английский

Citations

0
TFAP2A-regulated CRNDE enhances colon cancer progression and chemoresistance via RIPK3 interaction DOI Creative Commons
Xin Gao, Yanming Huang, Tai Wei

et al.

Functional & Integrative Genomics, Journal Year: 2025, Volume and Issue: 25(1)

Published: Feb. 15, 2025

Colon cancer (CC) is a common malignancy with rising incidence worldwide. Despite advances in treatment strategies, many patients still face poor prognosis due to the development of drug resistance. Long non-coding RNAs (lncRNAs) have emerged as important regulators various biological processes and been implicated progression. Among them, colorectal neoplasia differentially expressed (CRNDE) has drawn attention for its potential roles different cancers. However, specific functions CC remain unclear. In this study, we identified CRNDE highly CC, contributing tumor progression Mechanically, regulated by transcription factor TFAP2A. Additionally, inhibits pyroptosis, form programmed cell death, promoting ubiquitin-mediated degradation RIPK3, thereby reducing sensitivity cells 5-fluorouracil (5-FU). Our findings suggest that TFAP2A/CRNDE/RIPK3 axis plays critical colon chemoresistance, highlighting therapeutic targets improving outcomes.

Language: Английский

Citations

0
Carbohydrate polymer-functionalized metal nanoparticles in cancer therapy: A review DOI
Xi Zhou, Dongbin Zhang, Mingming Han

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 306, P. 141235 - 141235

Published: Feb. 21, 2025

Language: Английский

Citations

0
RIPK3 in Necroptosis and Cancer DOI Open Access

Michael J. Morgan,

You‐Sun Kim

Molecules and Cells, Journal Year: 2025, Volume and Issue: unknown, P. 100199 - 100199

Published: Feb. 1, 2025

Language: Английский

Citations

0
The Role of Post-Translational Modifications in Necroptosis DOI Creative Commons

Hao Xiao,

Zang Chao Han,

Min Xu

et al.

Biomolecules, Journal Year: 2025, Volume and Issue: 15(4), P. 549 - 549

Published: April 9, 2025

Necroptosis, a distinct form of regulated necrosis implicated in various human pathologies, is orchestrated through sophisticated signaling pathways. During this process, cells undergoing necroptosis exhibit characteristic necrotic morphology and provoke substantial inflammatory responses. Post-translational modifications (PTMs)—chemical alterations occurring after protein synthesis that critically regulate functionality—constitute essential regulatory components within these complex cascades. This intricate crosstalk between necroptotic pathways PTM networks presents promising therapeutic opportunities. Our comprehensive review systematically analyzes the molecular mechanisms underlying necroptosis, with particular emphasis on roles PTMs signal transduction. Through systematic evaluation key including ubiquitination, phosphorylation, glycosylation, methylation, acetylation, disulfide bond formation, caspase cleavage, nitrosylation, SUMOylation, we examine potential applications targeting disease pathogenesis. Furthermore, synthesize current pharmacological strategies for manipulating PTM-regulated offering novel perspectives clinical target development intervention.

Language: Английский

Citations

0
Multifunctional Nanoplatform Based on Gelatin Nanoparticles with Immunomodulatory Capabilities for Combined Immunotherapy and Chemotherapy of Melanoma DOI
Runsheng Chen, Miaomiao Zhang,

Zongjia Li

et al.

Biomacromolecules, Journal Year: 2025, Volume and Issue: unknown

Published: April 10, 2025

Tumor immunotherapy has shown considerable therapeutic potential, especially when combined with chemotherapy. In this study, we developed a multifunctional nanoplatform GNPs-DOX/R848 that and chemotherapy for the treatment of melanoma, in which gelatin nanoparticles (GNPs) were loaded immunomodulatory agent resiquimod (R848) drug doxorubicin (DOX). GNPs possessed inherent properties; R848, they induced more pronounced polarization M1-like macrophages by activating NF-κB signaling pathway, thereby reversing immunosuppressive tumor microenvironment. Meanwhile, effectively delivered R848 DOX to cells, promoting stronger effects drugs, strongly immunogenic cell death triggered DOX, leading infiltration T cells into tissue. The melanoma demonstrated significantly reduced volume, enhanced chemotherapy, providing new approach cancer

Language: Английский

Citations

0
Docetaxel combined with silver nanoparticles for synergistic therapy of prostate cancer via effectively inhibiting cell proliferation and inducing apoptosis DOI Creative Commons

Yanzhong Zhao,

Binlong Chen,

Zichang Lin

et al.

Materials & Design, Journal Year: 2025, Volume and Issue: unknown, P. 113953 - 113953

Published: April 1, 2025

Language: Английский

Citations

0
Multifunctional Chi-Ag@HMPB@CBD nanocomposites for eradicating multidrug-resistant bacteria and promoting diabetic damaged tissue repair DOI
Caiyun Yin,

Wu Zhou,

Aidi Tong

et al.

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 498, P. 155035 - 155035

Published: Aug. 23, 2024

Language: Английский

Citations

2