Nitrogen-Containing Heterocyclic Drug Products Approved by the FDA in 2023: Synthesis and biological activity

European Journal of Medicinal Chemistry, Год журнала: 2024, Номер 279, С. 116838 - 116838

Опубликована: Сен. 6, 2024

Язык: Английский

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Antineoplastic indole-containing compounds with potential VEGFR inhibitory properties

RSC Advances, Год журнала: 2024, Номер 14(9), С. 5690 - 5728

Опубликована: Янв. 1, 2024

VEGF, an important category of tyrosine kinases, and its receptors (VEGFR) are hyper-activated in different cancers. The recently reported indolyl analogs with potential antineoplastic VEGFR inhibitory properties highlighted.

Язык: Английский

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Design, synthesis, and evaluation of formylpiperazine analogs of Ferrostatin-1 as novel improved ferroptosis inhibitors

Bioorganic & Medicinal Chemistry, Год журнала: 2024, Номер 105, С. 117716 - 117716

Опубликована: Апрель 9, 2024

Язык: Английский

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Synthesis, Spectroscopic Characterization, DFT Analysis, Antibacterial, Antifungal, Antioxidant, Molecular docking, and ADME study of 3,4-dihydro-2H-napthalen-1-one tagged Chalcone derivatives

Journal of Molecular Structure, Год журнала: 2024, Номер 1322, С. 140313 - 140313

Опубликована: Окт. 9, 2024

Язык: Английский

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Recent advances on anticancer activity of benzodiazine heterocycles through kinase inhibition

RSC Advances, Год журнала: 2025, Номер 15(7), С. 5597 - 5638

Опубликована: Янв. 1, 2025

This is an updated review for the anticancer activity of benzodiazine heterocyclic derivatives through kinase inhibition.

Язык: Английский

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Deciphering the Fluorescence Response of Structurally Diverse Nitrogen Containing Small Heterocycles: A Combined Experimental and Computational Approach

Journal of Molecular Structure, Год журнала: 2025, Номер unknown, С. 141841 - 141841

Опубликована: Фев. 1, 2025

Язык: Английский

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Efficient production of 6-hydroxynicotinic acid by newly isolated Pseudomonas poae

Electronic Journal of Biotechnology, Год журнала: 2025, Номер unknown

Опубликована: Март 1, 2025

Язык: Английский

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Computational and Experimental Insights into the Anticancer Activity of Benzylidene Amino Benzoate Derivatives: A Study Based on Docking, DFT, and In Vitro Assays

Journal of Molecular Structure, Год журнала: 2025, Номер unknown, С. 142144 - 142144

Опубликована: Март 1, 2025

Язык: Английский

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Tailored horseshoe-shaped nicotinonitrile scaffold as dual promising c-Met and Pim-1 inhibitors: Design, synthesis, SAR and in silico study

Bioorganic Chemistry, Год журнала: 2023, Номер 143, С. 106988 - 106988

Опубликована: Ноя. 20, 2023

Язык: Английский

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Advances in Cancer Therapy: A Comprehensive Review of CDK and EGFR Inhibitors

Cells, Год журнала: 2024, Номер 13(19), С. 1656 - 1656

Опубликована: Окт. 6, 2024

Protein kinases have essential responsibilities in controlling several cellular processes, and their abnormal regulation is strongly related to the development of cancer. The implementation protein kinase inhibitors has significantly transformed cancer therapy by modifying treatment strategies. These received substantial FDA clearance recent decades. emerged as primary objectives for therapeutic interventions, particularly context treatment. At present, 69 therapeutics been approved that target approximately 24 kinases, which are specifically prescribed neoplastic illnesses. novel agents inhibit certain such receptor protein-tyrosine protein-serine/threonine dual-specificity nonreceptor kinases. This review presents a comprehensive overview targets inhibitors, with specific focus on cyclin-dependent (CDKs) epidermal growth factor (EGFR). majority reviewed studies commenced an assessment cell lines concluded biological evaluation individual targets. articles provide detailed information structural features potent anticancer activity, refers ability selectively cancer-promoting including CDKs EGFR. Additionally, latest FDA-approved targeting these enzymes were highlighted accordingly.

Язык: Английский

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