Recent advances in c-Met-based dual inhibitors in the treatment of cancers

European Journal of Medicinal Chemistry, Год журнала: 2024, Номер 272, С. 116477 - 116477

Опубликована: Май 8, 2024

Язык: Английский

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Novel sulfonamide-tethered Schiff bases as anti-proliferative agents with VEGFR-2 inhibitory activity: Synthesis, biological assessment, and molecular dynamic simulations

Journal of Molecular Structure, Год журнала: 2024, Номер 1309, С. 138148 - 138148

Опубликована: Март 26, 2024

Язык: Английский

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Identification of indole-grafted pyrazolopyrimidine and pyrazolopyridine derivatives as new anti-cancer agents: Synthesis, biological assessments, and molecular modeling insights

Bioorganic Chemistry, Год журнала: 2024, Номер 153, С. 107804 - 107804

Опубликована: Сен. 6, 2024

Язык: Английский

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Discovery of novel tris-1,2,3-triazole-based hybrids as VEGFR2 inhibitors with potent anti-proliferative and cytotoxicity through apoptosis induction

Bioorganic Chemistry, Год журнала: 2025, Номер 155, С. 108131 - 108131

Опубликована: Янв. 8, 2025

Язык: Английский

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Discovery of new 1,3-diphenylurea appended aryl pyridine derivatives as apoptosis inducers through c-MET and VEGFR-2 inhibition: design, synthesis, in vivo and in silico studies

RSC Medicinal Chemistry, Год журнала: 2024, Номер 15(7), С. 2553 - 2569

Опубликована: Янв. 1, 2024

A new 1,3-diphenylurea appended aryl pyridine derivative was designed, synthesized and characterized as c-MET VEGFR-2 inhibitors to induce apoptosis against MCF-7 cells.

Язык: Английский

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Current scenario of pyrazole hybrids with anti‐breast cancer therapeutic applications

Archiv der Pharmazie, Год журнала: 2024, Номер 357(10)

Опубликована: Июнь 29, 2024

Breast cancer stands as the leading cause of cancer-related deaths among women globally, but current therapy is restricted to serious adverse effects and multidrug resistance, necessitating exploration novel, safe, efficient anti-breast chemotherapeutic agents. Pyrazoles exhibit excellent potential for utilization effective agents due their ability act on various biological targets. Particularly, pyrazole hybrids demonstrated advantage targeting multiple pathways, some them, which are exemplified by larotrectinib (pyrazolo[1,5-a]pyrimidine hybrid), can be applied breast therapy. Thus, hold great promise useful therapeutic interventions cancer. The aim this review summarize scenario with in vitro and/or vivo potential, along modes action structure-activity relationships, covering articles published from 2020 present, streamline development rational, safe candidates.

Язык: Английский

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Fragment-based design and synthesis of coumarin-based thiazoles as dual c-MET/STAT-3 inhibitors for potential antitumor agents

Bioorganic Chemistry, Год журнала: 2024, Номер 151, С. 107682 - 107682

Опубликована: Авг. 6, 2024

Язык: Английский

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Cancer research in the United Arab Emirates from birth to present: A bibliometric analysis

Heliyon, Год журнала: 2024, Номер 10(6), С. e27201 - e27201

Опубликована: Март 1, 2024

BackgroundAccumulating evidence indicates that the incidence of cancer is increasing in United Arab Emirates (UAE). This analysis aimed to determine current research output UAE guide future national research.MethodsThe Scopus database was searched for cancer-related bibliographic data from UAE. The number publications, citation analysis, co-authorship author, institution, and country, keyword co-occurrence, reference co-citations were analyzed using R-studio bibliometrics package VOSviewer software.ResultsA total 1678 journal articles retrieved 1981 2022. Cancer (UCR) at a rate 14.64% (R-squared = 0.75; F 46.477; P<0.001). had 0.06% participation terms original articles. international 40.23%. U.S.A., U.K., Egypt, Saudi Arabia, India, Canada more than 100 co-authored documents 156 countries collaborated with U.A.E.ConclusionsCompared other nations, has fewer publications on cancer, although growing. report provides an up-to-date in-depth summary trends UCR. project excellent place researchers interested conducting data-mapping work this field.

Язык: Английский

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Synthesis of novel pyridine and pyrazolyl pyridine conjugates with potent cytotoxicity against HepG2 cancer cells as PIM-1 kinase inhibitors and caspase activators

RSC Advances, Год журнала: 2024, Номер 14(53), С. 39381 - 39394

Опубликована: Янв. 1, 2024

Novel pyridine and pyrazolyl derivatives were synthesized characterized with potent cytotoxicity against HepG2 cancer cells as PIM-1 kinase inhibitors caspase activators.

Язык: Английский

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