Promotion of ROS-mediated apoptosis, G2/M arrest, and autophagy by naringenin in non-small cell lung cancer
International Journal of Biological Sciences,
Год журнала:
2024,
Номер
20(3), С. 1093 - 1109
Опубликована: Янв. 1, 2024
Background:
As
lung
cancer
is
the
leading
cause
of
death
worldwide,
development
new
medicines
a
crucial
endeavor.Naringenin,
flavanone
derivative,
possesses
anti-cancer
and
anti-inflammatory
properties
has
been
reported
to
have
cytotoxic
effects
on
various
cells.The
current
study
investigated
underlying
molecular
mechanism
by
which
naringenin
induces
cell
in
cancer.Methods:
The
expression
apoptosis,
cycle
arrest,
autophagy
markers
H1299
A459
cells
was
evaluated
using
terminal
deoxynucleotidyl
transferase
dUTP
nick
end
labeling
assay
(TUNEL),
Western
blot,
Annexin
V/PI
stain,
PI
acridine
orange
staining,
transmission
electron
microscopy
(TEM).Using
fluorescence
microscopy,
DALGreen
used
observe
degradation
p62,
GFP-LC3
plasmid
evaluate
puncta
formation,
pcDNA3-GFP-LC3-RFP-LC3ΔG
flux.Furthermore,
effect
subcutaneous
xenograft
model.Results:
Naringenin
treatment
(H1299
A459)
reduced
viability
induced
arrest.Pretreatment
with
ROS
scavengers
(N-acetylcysteine
or
catalase)
suppressed
naringenin-induced
cleavage
apoptotic
protein
restored
cyclin-dependent
kinase
activity.Naringenin
also
triggered
mediating
generation,
thereby
activating
AMP-activated
(AMPK)
signaling.ROS
inhibition
not
only
inhibited
autophagic
formation
but
decreased
ratio
microtubule-associated
proteins
1A/1B
light
chain
3
II
(LC3II)/LC3I
activity
AMPK
signaling
pathway.Furthermore,
tumor
growth
promoted
apoptosis
mouse
model.
Conclusion:This
demonstrated
potent
cells,
providing
valuable
insights
for
developing
small-molecule
drugs
that
can
induce
death.
Язык: Английский
Structural characteristics and anti-tumor activity of alkali-extracted acidic polysaccharide extracted from Panax ginseng
International Journal of Biological Macromolecules,
Год журнала:
2025,
Номер
305, С. 141230 - 141230
Опубликована: Фев. 17, 2025
Язык: Английский
A bibliometric analysis of the application of the PI3K-AKT-mTOR signaling pathway in cancer
Naunyn-Schmiedeberg s Archives of Pharmacology,
Год журнала:
2024,
Номер
397(10), С. 7255 - 7272
Опубликована: Май 6, 2024
Язык: Английский
Unusual chaetoglobosins and a new type of ferroptosis inducer from an endophytic fungus Chaetomium sp. UJN-EF006
Bioorganic Chemistry,
Год журнала:
2025,
Номер
158, С. 108342 - 108342
Опубликована: Март 6, 2025
Язык: Английский
Bioactive monoterpenoids and acetophenones from the aerial parts of Eupatorium fortunei
Phytochemistry,
Год журнала:
2024,
Номер
219, С. 113984 - 113984
Опубликована: Янв. 22, 2024
Язык: Английский
The Discovery of Acremochlorins O-R from an Acremonium sp. through Integrated Genomic and Molecular Networking
Journal of Fungi,
Год журнала:
2024,
Номер
10(5), С. 365 - 365
Опубликована: Май 20, 2024
The
fermentation
of
a
soil-derived
fungus
Acremonium
sp.
led
to
the
isolation
thirteen
ascochlorin
congeners
through
integrated
genomic
and
Global
Natural
Product
Social
(GNPS)
molecular
networking.
Among
isolated
compounds,
we
identified
two
unusual
bicyclic
types,
acremochlorins
O
(1)
P
(2),
as
well
linear
acremochlorin
Q
(3)
R
(4).
Compounds
1
2
contain
an
benzopyran
moiety
are
diastereoisomers
each
other,
first
reported
for
ascochlorins.
Additionally,
elucidated
structure
5,
4-chloro-5-methylbenzene-1,3-diol
with
farnesyl
side
chain,
confirmed
presence
eight
known
analogs
(6–13).
structures
were
determined
by
detailed
interpretation
1D
2D
NMR
spectroscopy,
MS,
ECD
calculations.
3
9
showed
potent
antibacterial
activity
against
Staphylococcus
aureus
Bacillus
cereus,
MIC
values
ranging
from
16
μg/mL.
Язык: Английский
Daphne genkwa: Ethnopharmacology, phytochemistry and pharmacology of an important traditional Chinese medicine
Fitoterapia,
Год журнала:
2024,
Номер
177, С. 106089 - 106089
Опубликована: Июнь 19, 2024
Язык: Английский
Grifolin Induces Cell Death of Human Lung Cancer A549 Cell Line via Inhibiting KRAS‐Mediated Multiple Signaling Pathways
Xuechun Zhao,
Ren‐Fen Ma,
Hu Liu
и другие.
Chemistry & Biodiversity,
Год журнала:
2024,
Номер
21(7)
Опубликована: Май 13, 2024
In
the
current
work,
grifolin
was
obtained
from
twigs
and
leaves
of
Daphne
genkwa
for
first
time
displayed
significant
growth
inhibition
against
human
lung
carcinoma
A549
cells.
Subsequent
in
vitro
antitumor
evaluation
revealed
that
could
induce
remarkable
cell
apoptosis
G
Язык: Английский
Rare flavanone-diarylheptanoid hybrids from Typha angustifolia shows anti breast cancer activity via activating TGF-β1/Smad signaling pathway
European Journal of Medicinal Chemistry,
Год журнала:
2024,
Номер
268, С. 116220 - 116220
Опубликована: Фев. 15, 2024
Язык: Английский
Target isolation of diverse sesquiterpenoid from the stems of Daphne genkwa based on molecular networking
Journal of Asian Natural Products Research,
Год журнала:
2024,
Номер
unknown, С. 1 - 12
Опубликована: Март 26, 2024
Guiding
by
LC-MS/MS
analysis
and
the
Global
Natural
Products
Social
(GNPS)
Molecular
Networking,
three
undescribed
sesquiterpenoids,
stedapgens
A–C,
two
known
analogues
were
discovered
in
barks
of
Daphne
genkwa
Sieb.
et
Zucc.
The
structures
determined
their
spectroscopic
data
quantum-chemical
calculations.
All
isolated
novel
compounds
tested
for
acetylcholinesterase
inhibitory
activities
with
IC50
=
0.754
±
0.059,
0.696
0.026,
0.337
0.023
μg/ml.
Among
them,
stedapgen
A
displayed
promising
against
AChE,
binding
sites
predicted
molecular
docking.
Язык: Английский