Synthesis of novel pyridine and pyrazolyl pyridine conjugates with potent cytotoxicity against HepG2 cancer cells as PIM-1 kinase inhibitors and caspase activators DOI Creative Commons
Mohamed S. Nafie, Ahmed Hamza, Ahmed H. Moustafa

et al.

RSC Advances, Journal Year: 2024, Volume and Issue: 14(53), P. 39381 - 39394

Published: Jan. 1, 2024

Novel pyridine and pyrazolyl derivatives were synthesized characterized with potent cytotoxicity against HepG2 cancer cells as PIM-1 kinase inhibitors caspase activators.

Language: Английский

Recent advances in c-Met-based dual inhibitors in the treatment of cancers DOI

Fanqi Jin,

Yi‐Han Lin,

Yuan Weidong

et al.

European Journal of Medicinal Chemistry, Journal Year: 2024, Volume and Issue: 272, P. 116477 - 116477

Published: May 8, 2024

Language: Английский

Citations

11
Novel sulfonamide-tethered Schiff bases as anti-proliferative agents with VEGFR-2 inhibitory activity: Synthesis, biological assessment, and molecular dynamic simulations DOI
Moataz A. Shaldam,

Maha-Hamadien Abdulla,

Andrea Angeli

et al.

Journal of Molecular Structure, Journal Year: 2024, Volume and Issue: 1309, P. 138148 - 138148

Published: March 26, 2024

Language: Английский

Citations

8
Identification of indole-grafted pyrazolopyrimidine and pyrazolopyridine derivatives as new anti-cancer agents: Synthesis, biological assessments, and molecular modeling insights DOI
Wagdy M. Eldehna, Haytham O. Tawfik,

Maha-Hamadien Abdulla

et al.

Bioorganic Chemistry, Journal Year: 2024, Volume and Issue: 153, P. 107804 - 107804

Published: Sept. 6, 2024

Language: Английский

Citations

6
Discovery of novel tris-1,2,3-triazole-based hybrids as VEGFR2 inhibitors with potent anti-proliferative and cytotoxicity through apoptosis induction DOI
Mosa Alsehli,

Adeeb Al Sheikh Ali,

Mohamed S. Nafie

et al.

Bioorganic Chemistry, Journal Year: 2025, Volume and Issue: 155, P. 108131 - 108131

Published: Jan. 8, 2025

Language: Английский

Citations

0
Discovery of new 1,3-diphenylurea appended aryl pyridine derivatives as apoptosis inducers through c-MET and VEGFR-2 inhibition: design, synthesis, in vivo and in silico studies DOI

Heba A. Elsebaie,

Mohamed S. Nafie, Haytham O. Tawfik

et al.

RSC Medicinal Chemistry, Journal Year: 2024, Volume and Issue: 15(7), P. 2553 - 2569

Published: Jan. 1, 2024

A new 1,3-diphenylurea appended aryl pyridine derivative was designed, synthesized and characterized as c-MET VEGFR-2 inhibitors to induce apoptosis against MCF-7 cells.

Language: Английский

Citations

1
Current scenario of pyrazole hybrids with anti‐breast cancer therapeutic applications DOI
Mengyu Ma

Archiv der Pharmazie, Journal Year: 2024, Volume and Issue: 357(10)

Published: June 29, 2024

Breast cancer stands as the leading cause of cancer-related deaths among women globally, but current therapy is restricted to serious adverse effects and multidrug resistance, necessitating exploration novel, safe, efficient anti-breast chemotherapeutic agents. Pyrazoles exhibit excellent potential for utilization effective agents due their ability act on various biological targets. Particularly, pyrazole hybrids demonstrated advantage targeting multiple pathways, some them, which are exemplified by larotrectinib (pyrazolo[1,5-a]pyrimidine hybrid), can be applied breast therapy. Thus, hold great promise useful therapeutic interventions cancer. The aim this review summarize scenario with in vitro and/or vivo potential, along modes action structure-activity relationships, covering articles published from 2020 present, streamline development rational, safe candidates.

Language: Английский

Citations

1
Fragment-based design and synthesis of coumarin-based thiazoles as dual c-MET/STAT-3 inhibitors for potential antitumor agents DOI
Bassem H. Naguib,

Heba A. Elsebaie,

Mohamed S. Nafie

et al.

Bioorganic Chemistry, Journal Year: 2024, Volume and Issue: 151, P. 107682 - 107682

Published: Aug. 6, 2024

Language: Английский

Citations

1
Cancer research in the United Arab Emirates from birth to present: A bibliometric analysis DOI Creative Commons
Humaid O. Al‐Shamsi, Siddig İbrahim Abdelwahab, Osama Albasheer

et al.

Heliyon, Journal Year: 2024, Volume and Issue: 10(6), P. e27201 - e27201

Published: March 1, 2024

BackgroundAccumulating evidence indicates that the incidence of cancer is increasing in United Arab Emirates (UAE). This analysis aimed to determine current research output UAE guide future national research.MethodsThe Scopus database was searched for cancer-related bibliographic data from UAE. The number publications, citation analysis, co-authorship author, institution, and country, keyword co-occurrence, reference co-citations were analyzed using R-studio bibliometrics package VOSviewer software.ResultsA total 1678 journal articles retrieved 1981 2022. Cancer (UCR) at a rate 14.64% (R-squared = 0.75; F 46.477; P<0.001). had 0.06% participation terms original articles. international 40.23%. U.S.A., U.K., Egypt, Saudi Arabia, India, Canada more than 100 co-authored documents 156 countries collaborated with U.A.E.ConclusionsCompared other nations, has fewer publications on cancer, although growing. report provides an up-to-date in-depth summary trends UCR. project excellent place researchers interested conducting data-mapping work this field.

Language: Английский

Citations

0
Synthesis of novel pyridine and pyrazolyl pyridine conjugates with potent cytotoxicity against HepG2 cancer cells as PIM-1 kinase inhibitors and caspase activators DOI Creative Commons
Mohamed S. Nafie, Ahmed Hamza, Ahmed H. Moustafa

et al.

RSC Advances, Journal Year: 2024, Volume and Issue: 14(53), P. 39381 - 39394

Published: Jan. 1, 2024

Novel pyridine and pyrazolyl derivatives were synthesized characterized with potent cytotoxicity against HepG2 cancer cells as PIM-1 kinase inhibitors caspase activators.

Language: Английский

Citations

0