Current Molecular Medicine,
Год журнала:
2020,
Номер
20(7), С. 516 - 526
Опубликована: Янв. 29, 2020
Circular
RNAs,
a
group
of
endogenous
non-coding
are
characterized
by
covalently
closed
cyclic
structures
with
no
poly-adenylated
tails.
It
has
been
recently
recommended
that
cirRNAs
have
an
essential
role
in
regulating
genes
expression
functioning
as
translational
regulator,
RNA
binding
protein
sponge
and
microRNA
sponge.
Due
to
their
close
relation
the
progression
various
diseases
such
diabetes,
circRNAs
become
research
hotspot.
A
number
(i.e.,
circRNA_0054633,
circHIPK3,
circANKRD36,
circRNA11783-2)
shown
be
associated
initiation
diabetes.
Based
on
reports,
tissue,
some
expressed
developmental
stage-specific
manner.
In
this
study,
we
reviewed
circular
RNAs
involved
pathogenesis
diagnosis
diabetes
prognostic
roles.
Molecular Medicine Reports,
Год журнала:
2019,
Номер
unknown
Опубликована: Март 6, 2019
Circular
RNAs
(circRNAs)
are
endogenous
non‑coding
implicated
in
atherosclerosis.
The
aim
of
the
present
study
was
to
explore
function
circRNA‑0044073
Reverse
transcription
quantitative
polymerase
chain
reaction
assays
were
used
measure
expression
levels
circRNA‑0044073,
microRNA
(miRNA/miR)‑107,
janus
kinase
1
(JAK1),
signal
transducer
and
activator
3
(STAT3),
B‑cell
lymphoma
2
(Bcl‑2)
v‑myc
avian
myelocytomatosis
viral
oncogene
homolog
(c‑myc)
blood
cells
from
patients
with
RNA
pull‑down
luciferase
reporter
then
determine
association
between
circRNA
miR
expression,
gene
respectively.
Matrigel
invasion
assay
flow
cytometry
analyze
cell
cycle.
Western
blot
analysis
ELISA
evaluate
proteins.
It
identified
that
upregulated
miR‑107
downregulated
atherosclerotic
cells.
Overexpression
promoted
proliferation
human
vascular
smooth
muscle
(HUVSMCs)
endothelial
(HUVECs),
while
overexpression
inhibited
their
proliferation.
In
addition,
suppressed
via
a
sponge
mechanism.
Lipopolysaccharide
(LPS)
affected
HUVSMCs
HUVECs,
also
resulted
changes
levels.
CircRNA‑0044073
HUVECs
spite
opposite
effect
observed
LPS
treatment.
JAK/STAT
signaling
pathway
activated
favored
activation
inflammation
HUVECs.
These
data
indicate
is
atherosclerosis
promotes
by
targeting
activating
pathway,
potentially
offering
target
for
novel
treatment
strategies
against
BMC Bioinformatics,
Год журнала:
2018,
Номер
19(S19)
Опубликована: Дек. 1, 2018
Many
evidences
have
demonstrated
that
circRNAs
(circular
RNA)
play
important
roles
in
controlling
gene
expression
of
human,
mouse
and
nematode.
More
importantly,
are
also
involved
many
diseases
through
fine
tuning
post-transcriptional
by
sequestering
the
miRNAs
which
associate
with
diseases.
Therefore,
identifying
circRNA-disease
associations
is
very
appealing
to
comprehensively
understand
mechanism,
treatment
diagnose
diseases,
yet
challenging.
As
complex
mechanism
between
wet-lab
experiments
expensive
time-consuming
discover
novel
associations.
it
dire
need
employ
computational
methods
associations.In
this
study,
we
develop
a
method
(DWNN-RLS)
predict
based
on
Regularized
Least
Squares
Kronecker
product
kernel.
The
similarity
computed
from
Gaussian
Interaction
Profile(GIP)
known
In
addition,
integrated
mean
GIP
sematic
direct
acyclic
graph
(DAG)
representation
kernels
pairs
constructed
DWNN
(decreasing
weight
k-nearest
neighbor)
adopted
calculate
initial
relational
score
for
new
kernel
regularised
least
squares
approach
used
We
adopt
5-fold
cross
validation
(5CV),
10-fold
(10CV)
leave
one
out
(LOOCV)
assess
prediction
performance
our
method,
compare
other
six
competing
(RLS-avg,
RLS-Kron,
NetLapRLS,
KATZ,
NBI,
WP).The
experiment
results
show
DWNN-RLS
reaches
AUC
values
0.8854,
0.9205
0.9701
5CV,
10CV
LOOCV,
respectively,
illustrates
superior
RLS-avg,
WP.
case
studies
an
effective
Abstract
Background
Circular
RNAs
(circRNAs)
are
a
new
class
of
endogenous
non-coding
(ncRNAs)
widely
expressed
in
eukaryotic
cells.
Mounting
evidence
has
highlighted
circRNAs
as
critical
regulators
various
tumours.
More
importantly,
have
been
revealed
to
recruit
and
reprogram
key
components
involved
the
tumour
microenvironment
(TME),
mediate
signaling
pathways,
thus
affecting
tumourigenesis,
angiogenesis,
immune
response,
metastatic
progression.
Main
body
abstract
In
this
review,
we
briefly
introduce
biogenesis,
characteristics
classification
circRNAs,
describe
mechanistic
models
circRNAs.
Further,
provide
first
systematic
overview
interplay
between
cellular/non-cellular
counterparts
TME
highlight
potential
prospective
biomarkers
or
targets
cancer
clinics.
Finally,
discuss
biological
mechanisms
through
which
drive
development
resistance,
revealing
mystery
drug
resistance
Short
conclusion
Deep
understanding
emerging
role
their
involvements
may
therapeutic
for
patients.
The
combined
targeting
co-activated
achieve
higher
efficiency
become
mode
therapy
future.
Critical Reviews in Food Science and Nutrition,
Год журнала:
2022,
Номер
64(8), С. 2157 - 2175
Опубликована: Сен. 13, 2022
Natural
products
possess
pleiotropic
cardiovascular
protective
effects
owing
to
their
anti-oxidation,
anti-inflammation
and
anti-thrombotic
properties.
Kaempferol,
(3,5,7-trihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one),
is
a
kind
of
naturally
occurring
flavonoid
existing
in
many
common
fruits
vegetables
(e.g.,
onions,
broccoli,
strawberries
grapes)
particularly
traditional
Chinese
medicine
as
exemplified
by
Ginkgo
biloba.
Epidemiological,
preclinical
clinical
studies
have
revealed
an
inverse
association
between
the
consumption
kaempferol-containing
foods
medicines
risk
developing
diseases.
Numerous
translational
experimental
animal
models
cultured
cells
demonstrated
wide
range
pharmacological
activities
kaempferol.
In
this
article,
we
reviewed
antioxidant,
anti-inflammatory
cardio-protective
kaempferol
elucidated
potential
molecular
basis
therapeutic
capacity
focusing
on
its
anti-atherosclerotic
effects.
Overall,
review
presents
health
benefits
plants
reflects
possible
drug
candidate
prevent
treat
atherosclerosis,
underlying
pathology
most
