Molecular mechanisms and therapeutic applications of huaier in breast cancer treatment DOI Creative Commons

Ke-fei Luo,

Linxi Zhou,

Zi-wei Wu

и другие.

Frontiers in Pharmacology, Год журнала: 2024, Номер 14

Опубликована: Янв. 12, 2024

Breast cancer is one of the most common female malignant tumors today and represents a serious health risk for women. Although survival rate quality life patients with breast are improving continuous development medical technology, metastasis, recurrence, drug resistance remain significant problem. Huaier, traditional Chinese medicine (TCM) fungus, type Sophora embolism fungus growing on old stems. The polysaccharides Trametes robiniophila Murr (PS-T) main active ingredient Huaier. There increasing evidence that Huaier has great potential in treatment, its anti-cancer mechanism may be related to variety biological activities, such as inhibition cell proliferation, tumor angiogenesis, promotion death, regulation tumor-specific immunity. effective clinical treatment cancer. This review systematically summarizes basic studies use cancer, providing useful information guide application future studies.

Язык: Английский

A network pharmacology approach and experimental validation to investigate the anticancer mechanism of Qi-Qin-Hu-Chang formula against colitis-associated colorectal cancer through induction of apoptosis via JNK/p38 MAPK signaling pathway DOI Creative Commons

Yuguang Wu,

Yulai Fang, Yanan Li

и другие.

Journal of Ethnopharmacology, Год журнала: 2023, Номер 319, С. 117323 - 117323

Опубликована: Окт. 16, 2023

The Qi-Qin-Hu-Chang Formula (QQHCF) is a traditional Chinese medicine prescription that clinically used at the Affiliated Hospital of Nanjing University Medicine for treatment colitis-associated colorectal cancer (CAC).

Язык: Английский

Процитировано

27
The effective combination therapies with irinotecan for colorectal cancer DOI Creative Commons
Yun Chai, Jingli Liu, Shuo Zhang

и другие.

Frontiers in Pharmacology, Год журнала: 2024, Номер 15

Опубликована: Фев. 5, 2024

Colorectal cancer is the third most common type of worldwide and has become one major human disease burdens. In clinical practice, treatment colorectal been closely related to use irinotecan. Irinotecan combines with many other anticancer drugs a broader range drug combinations. Combination therapy important means improving anti-tumor efficacy overcoming resistance. Reasonable combination can lead better patient options, inappropriate will increase risk. For therapeutic field, significance improve efficacy, reduce adverse effects, ease treatment. Therefore, we explored advantages its based on mechanism or metabolism reviewed rationale basis limitations in conducting exploratory trials irinotecan therapy, including results potentiation cytotoxic drugs, targeted agents, herbal medicine. We hope that these evoke more efforts conduct laboratory for further studies evaluations, as well possibility in-depth development future trials.

Язык: Английский

Процитировано

15
Potential effects and mechanism of flavonoids extract of Callicarpa nudiflora Hook on DSS-induced colitis in mice DOI

Keyi Nong,

Xinyun Qin, Zhineng Liu

и другие.

Phytomedicine, Год журнала: 2024, Номер 128, С. 155523 - 155523

Опубликована: Март 9, 2024

Язык: Английский

Процитировано

14
Modified Banxiaxiexin decoction benefitted chemotherapy in treating gastric cancer by regulating multiple targets and pathways DOI
Zhipeng Zhang, Chao Wu,

Ningning Liu

и другие.

Journal of Ethnopharmacology, Год журнала: 2024, Номер 331, С. 118277 - 118277

Опубликована: Апрель 30, 2024

Язык: Английский

Процитировано

10
Mechanism of Zhishi Xiebai Guizhi decoction to treat atherosclerosis: Insights into experiments, network pharmacology and molecular docking DOI Creative Commons
Zhuojun Zhang,

Jin Gao,

Junpeng Wang

и другие.

Journal of Ethnopharmacology, Год журнала: 2024, Номер 333, С. 118466 - 118466

Опубликована: Июнь 15, 2024

Zhishi Xiebai Guizhi Decoction (ZSXBGZD) is a traditional herbal manuscript used to treat cardiovascular disease, including atherosclerosis and coronary heart disease. The decoction has demonstrated its capability protect arteries resist atherosclerosis. Its mechanisms for anti-atherosclerosis effect, nevertheless, remain unknown.

Язык: Английский

Процитировано

9
Network pharmacology alliance with experimental validation unveils the anti-colorectal cancer mechanism of Xianlian Jiedu Decoction DOI
Xiaoxuan Fan,

Qiuying Yan,

Wei‐Cheng Xu

и другие.

Journal of Ethnopharmacology, Год журнала: 2025, Номер unknown, С. 119361 - 119361

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

1
The active components and potential mechanisms of Li-Chong-Xiao-Zhen granules in the treatment of ovarian cancer: An integrated metabolomics, proteomics, network pharmacology and experimental validation DOI Creative Commons
Yiliu Chen, Rina Su, Guilin Hu

и другие.

Journal of Ethnopharmacology, Год журнала: 2025, Номер unknown, С. 119474 - 119474

Опубликована: Фев. 1, 2025

Язык: Английский

Процитировано

1
Natural products modulating MAPK for CRC treatment: a promising strategy DOI Creative Commons
Lin Zhou, Jinlong Zhang, Kangning Zhao

и другие.

Frontiers in Pharmacology, Год журнала: 2025, Номер 16

Опубликована: Март 5, 2025

Colorectal cancer (CRC) is a common malignant tumor of the digestive system, and pathogenic mechanism still unclear, mostly related to genetics, immunity, inflammation, abnormal activation tumor-related signaling pathways. MAPK belongs Ser/Thr kinase family, which plays an important role in complex cellular programs such as regulation cell proliferation, differentiation, apoptosis, angiogenesis, metastasis. Increasing evidence supports that highly correlated with risk CRC. Targeting may be therapeutic strategy, natural products show great potential regulating MAPK-related proteins. In this paper, we searched PubMed, Web Science CNKI databases keywords "colorectal cancer, products, pathway, ERK, P38, JNK" for relevant studies last 14 years from 2010 2024. This work retrieved 47 studies, aiming provide new strategies CRC patients lay foundation drug development.

Язык: Английский

Процитировано

1
Syringin exerts anti-breast cancer effects through PI3K-AKT and EGFR-RAS-RAF pathways DOI Creative Commons
Fei Wang, Chong Yuan, Bo Liu

и другие.

Journal of Translational Medicine, Год журнала: 2022, Номер 20(1)

Опубликована: Июль 6, 2022

Breast cancer (BC) is one of the most common malignant tumors with highest mortality in world. Modern pharmacological studies have shown that Syringin has an inhibitory effect on many tumors, but its anti-BC efficacy and mechanism are still unclear.First, was isolated from Acanthopanax senticosus (Rupr. & Maxim.) Harms (ASH) by systematic solvent extraction silica gel chromatography column. The plant name composed genus epithet, species additive words persons' who give name. Then, hub targets against BC were revealed bioinformatics. To provide a more experimental basis for later research, genes which could be candidate biomarkers ceRNA network related to them obtained. And potential proved vitro experiments.Syringin obtained liquid chromatography-mass spectrometry (LC-MS), nuclear magnetic resonance (NMR), high-performance (HPLC). Bioinformatics results showed MAP2K1, PIK3CA, HRAS, EGFR, Caspase3, PTGS2 BC. PIK3CA HRAS survival prognosis patients, PIK3CA-hsa-mir-139-5p-LINC01278 PIK3CA-hsa-mir-375 pathways might closely In experiments confirmed inhibited proliferation migration promoted apoptosis cells through above targets.Syringin via PI3K-AKT-PTGS2 EGFR-RAS-RAF-MEK-ERK pathways, adjuvant treatment

Язык: Английский

Процитировано

31
Poria Acid, Triterpenoids Extracted from Poria cocos, Inhibits the Invasion and Metastasis of Gastric Cancer Cells DOI Creative Commons
Haibo Wang, Yuanyuan Luo, Zewen Chu

и другие.

Molecules, Год журнала: 2022, Номер 27(11), С. 3629 - 3629

Опубликована: Июнь 6, 2022

Poria cocos (P. cocos) is an important medicinal fungus in traditional Chinese medicine. acid (PA), a triterpenoid compound, effective component of medicine P. cocos. This experiment investigated the anti-gastric cancer biological activity PA vitro.The effect on viability gastric cells was detected by thiazolyl blue (MTT) assay. Cell adhesion assays were used to detect changes treated after (0, 20, 40, and 80 µmol/L). The ability cell invasion migration Transwell wound healing assays. A high-content imaging system dynamically record motility µmol/L) treatment. Western blotting expression epithelial-mesenchymal transformation (EMT), related proteins.The MTT assay showed that proliferation significantly inhibited experiments decreased Compared with control group, area different concentrations decreased. number passing through membrane reduced In addition, treatment, cells' movement distance average speed lower than those group. Finally, can alter EMT-related proteins E-cadherin, N-cadherin, Vimentin expressions metastasis-related matrix metalloproteinase (MMP) 2, MMP-9 tissue inhibition (TIMP)1 cells.Triterpenoids from have significant against cancer, mechanism may be involved process transformation.

Язык: Английский

Процитировано

29