Exosome-like nanoparticles derived from fruits, vegetables, and herbs: innovative strategies of therapeutic and drug delivery

Theranostics, Journal Year: 2024, Volume and Issue: 14(12), P. 4598 - 4621

Published: Jan. 1, 2024

Over the past ten years, significant advancements have been made in exploring plant-derived exosome-like nanoparticles (PELNs) for disease therapeutics and drug delivery. PELNs, as inherent nanoscale particles comprised of proteins, lipids, nucleic acids, secondary metabolites, exhibit capacity cellular uptake by human cells. This intercellular interaction transcends biological boundaries, effectively influencing functions animals. PELNs outstanding biocompatibility, low immunogenicity, enhanced safety, environmentally friendly sustainability. article summarized preparation methods characteristics PELNs. It provided a systematic review varied roles derived from fruits, vegetables, herbs The challenges their production application were discussed, future prospects this rapidly evolving field explored.

Language: Английский

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The effective combination therapies with irinotecan for colorectal cancer

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: Feb. 5, 2024

Colorectal cancer is the third most common type of worldwide and has become one major human disease burdens. In clinical practice, treatment colorectal been closely related to use irinotecan. Irinotecan combines with many other anticancer drugs a broader range drug combinations. Combination therapy important means improving anti-tumor efficacy overcoming resistance. Reasonable combination can lead better patient options, inappropriate will increase risk. For therapeutic field, significance improve efficacy, reduce adverse effects, ease treatment. Therefore, we explored advantages its based on mechanism or metabolism reviewed rationale basis limitations in conducting exploratory trials irinotecan therapy, including results potentiation cytotoxic drugs, targeted agents, herbal medicine. We hope that these evoke more efforts conduct laboratory for further studies evaluations, as well possibility in-depth development future trials.

Language: Английский

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The active components and potential mechanisms of Li-Chong-Xiao-Zhen granules in the treatment of ovarian cancer: An integrated metabolomics, proteomics, network pharmacology and experimental validation

Journal of Ethnopharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 119474 - 119474

Published: Feb. 1, 2025

Language: Английский

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Arctium lappa (Burdock): Insights from ethnopharmacology potential, chemical constituents, clinical studies, pharmacological utility and nanomedicine

Biomedicine & Pharmacotherapy, Journal Year: 2022, Volume and Issue: 158, P. 114104 - 114104

Published: Dec. 12, 2022

Arctium lappa L. is a medicinal edible homologous plant, commonly known as burdock or bardana, which belongs to the Asteraceae family. It widely distributed throughout Northern Asia, Europe, and North America has been utilized for hundreds of years. The roots, fruits, seeds, leaves A. have extensively used in traditional Chinese Medicine (TCM). attracted great deal attention due its possession highly recognized bioactive metabolites with significant therapeutic potential. Numerous pharmacological effects demonstrated vitro vivo by metabolites, including antimicrobial, anti-obesity, antioxidant, anticancer, anti-inflammatory, anti-diabetic, anti-allergic, antiviral, gastroprotective, hepatoprotective, neuroprotective activities. Additionally, considerable clinical efficacies valuable applications nanomedicine. Collectively, this review covers properties ethnopharmacology aspects, effects, trials, field Hence, should be paid trials industrial plant particular emphasis, on drug discovery nanotechnology.

Language: Английский

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Syringin exerts anti-breast cancer effects through PI3K-AKT and EGFR-RAS-RAF pathways

Journal of Translational Medicine, Journal Year: 2022, Volume and Issue: 20(1)

Published: July 6, 2022

Breast cancer (BC) is one of the most common malignant tumors with highest mortality in world. Modern pharmacological studies have shown that Syringin has an inhibitory effect on many tumors, but its anti-BC efficacy and mechanism are still unclear.First, was isolated from Acanthopanax senticosus (Rupr. & Maxim.) Harms (ASH) by systematic solvent extraction silica gel chromatography column. The plant name composed genus epithet, species additive words persons' who give name. Then, hub targets against BC were revealed bioinformatics. To provide a more experimental basis for later research, genes which could be candidate biomarkers ceRNA network related to them obtained. And potential proved vitro experiments.Syringin obtained liquid chromatography-mass spectrometry (LC-MS), nuclear magnetic resonance (NMR), high-performance (HPLC). Bioinformatics results showed MAP2K1, PIK3CA, HRAS, EGFR, Caspase3, PTGS2 BC. PIK3CA HRAS survival prognosis patients, PIK3CA-hsa-mir-139-5p-LINC01278 PIK3CA-hsa-mir-375 pathways might closely In experiments confirmed inhibited proliferation migration promoted apoptosis cells through above targets.Syringin via PI3K-AKT-PTGS2 EGFR-RAS-RAF-MEK-ERK pathways, adjuvant treatment

Language: Английский

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Poria Acid, Triterpenoids Extracted from Poria cocos, Inhibits the Invasion and Metastasis of Gastric Cancer Cells

Molecules, Journal Year: 2022, Volume and Issue: 27(11), P. 3629 - 3629

Published: June 6, 2022

Poria cocos (P. cocos) is an important medicinal fungus in traditional Chinese medicine. acid (PA), a triterpenoid compound, effective component of medicine P. cocos. This experiment investigated the anti-gastric cancer biological activity PA vitro.The effect on viability gastric cells was detected by thiazolyl blue (MTT) assay. Cell adhesion assays were used to detect changes treated after (0, 20, 40, and 80 µmol/L). The ability cell invasion migration Transwell wound healing assays. A high-content imaging system dynamically record motility µmol/L) treatment. Western blotting expression epithelial-mesenchymal transformation (EMT), related proteins.The MTT assay showed that proliferation significantly inhibited experiments decreased Compared with control group, area different concentrations decreased. number passing through membrane reduced In addition, treatment, cells' movement distance average speed lower than those group. Finally, can alter EMT-related proteins E-cadherin, N-cadherin, Vimentin expressions metastasis-related matrix metalloproteinase (MMP) 2, MMP-9 tissue inhibition (TIMP)1 cells.Triterpenoids from have significant against cancer, mechanism may be involved process transformation.

Language: Английский

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Formation of a traditional Chinese medicine self-assembly nanostrategy and its application in cancer: a promising treatment

Chinese Medicine, Journal Year: 2023, Volume and Issue: 18(1)

Published: June 6, 2023

Traditional Chinese medicine (TCM) has been used for centuries to prevent and treat a variety of illnesses, its popularity is increasing worldwide. However, the clinical applications natural active components in TCM are hindered by poor solubility low bioavailability these compounds. To address issues, self-assembly nanostrategy (CSAN) being developed. Many possess properties, allowing them form nanoparticles (NPs) through various noncovalent forces. Self-assembled NPs (SANs) also present decoctions, they closely linked therapeutic effects remedies. SAN gaining nano research field due simplicity, eco-friendliness, enhanced biodegradability biocompatibility compared traditional preparation methods. The ingredients from that exhibit antitumour or combined with other drugs generated considerable interest cancer therapeutics. This paper provides review principles forms CSAN, as well an overview recent reports on can be self-assembly. Additionally, application CSAN diseases summarized, finally, concluding summary thoughts proposed. We strongly believe potential offer fresh strategies perspectives modernization TCM.

Language: Английский

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Research progress on the anti-tumor effect of Naringin

Frontiers in Pharmacology, Journal Year: 2023, Volume and Issue: 14

Published: Aug. 17, 2023

Naringin is a kind of natural dihydro flavone, which mainly exists in citrus fruits the Rutaceae family, as well traditional Chinese medicines such trifoliate orange, fingered citron, exocarpium citri grandis, and rhizoma dynamite. Modern pharmacological studies have shown that has excellent anti-tumor activity. Through reviewing relevant literature at home abroad recent years, we summarized mechanism to play an anti-cancer role blocking tumor cell cycle, inhibiting proliferation, inducing apoptosis, invasion metastasis, autophagy, reversing drug resistance enhancing chemotherapeutic sensitivity, anti-inflammatory prevent canceration, alleviate Adverse reaction chemotherapy, activate strengthen immunity, It provides theoretical basis reference for further exploring anticancer potential its development utilization.

Language: Английский

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Fabrication of pH/photothermal-responsive ZIF-8 nanocarriers loaded with baicalein for effective drug delivery and synergistic chem-photothermal effects

Colloids and Surfaces A Physicochemical and Engineering Aspects, Journal Year: 2023, Volume and Issue: 668, P. 131401 - 131401

Published: April 3, 2023

Language: Английский

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Molecular mechanisms and therapeutic applications of huaier in breast cancer treatment

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 14

Published: Jan. 12, 2024

Breast cancer is one of the most common female malignant tumors today and represents a serious health risk for women. Although survival rate quality life patients with breast are improving continuous development medical technology, metastasis, recurrence, drug resistance remain significant problem. Huaier, traditional Chinese medicine (TCM) fungus, type Sophora embolism fungus growing on old stems. The polysaccharides Trametes robiniophila Murr (PS-T) main active ingredient Huaier. There increasing evidence that Huaier has great potential in treatment, its anti-cancer mechanism may be related to variety biological activities, such as inhibition cell proliferation, tumor angiogenesis, promotion death, regulation tumor-specific immunity. effective clinical treatment cancer. This review systematically summarizes basic studies use cancer, providing useful information guide application future studies.

Language: Английский

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