The Journal of Nutritional Biochemistry, Год журнала: 2024, Номер 130, С. 109648 - 109648
Опубликована: Апрель 15, 2024
Язык: Английский
International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(9), С. 7898 - 7898
Опубликована: Апрель 26, 2023
Metabolic syndrome is a cluster of conditions associated with the risk diabetes mellitus type 2 and cardiovascular diseases (CVDs). closely related to obesity. Increased adiposity promotes inflammation oxidative stress, which are precursors various complications involving metabolic components, namely insulin resistance, hypertension, hyperlipidemia. An increasing number studies confirm importance stress chronic in etiology syndrome. However, few have reviewed mechanisms underlying role contributing In this review, we highlight by reactive oxygen species (ROS) increase mitochondrial dysfunction, protein damage, lipid peroxidation, impair antioxidant function Biomarkers can be used disease diagnosis evaluation severity.
Язык: Английский
Процитировано
262
Frontiers in Endocrinology, Год журнала: 2023, Номер 14
Опубликована: Март 28, 2023
Insulin resistance (IR) plays a crucial role in the development and progression of metabolism-related diseases such as diabetes, hypertension, tumors, nonalcoholic fatty liver disease, provides basis for common understanding these chronic diseases. In this study, we provide systematic review causes, mechanisms, treatments IR. The pathogenesis IR depends on genetics, obesity, age, drug effects. Mechanistically, any factor leading to abnormalities insulin signaling pathway leads host, including receptor abnormalities, disturbances internal environment (regarding inflammation, hypoxia, lipotoxicity, immunity), metabolic function organelles, other abnormalities. available therapeutic strategies are mainly exercise dietary habit improvement, chemotherapy based biguanides glucagon-like peptide-1, traditional Chinese medicine (e.g., herbs acupuncture) can also be helpful. Based current there still some vacancies follow up consider, is need define more precise biomarkers different lifestyle interventions, explore natural or synthetic drugs targeting treatment. This could enable treatment patients with multiple combined diseases, aim treating disease holistically reduce healthcare expenditures improve quality life extent.
Язык: Английский
Процитировано
211
Acta Pharmaceutica Sinica B, Год журнала: 2023, Номер 13(6), С. 2403 - 2424
Опубликована: Янв. 13, 2023
The occurrence of obesity has increased across the whole world. Many epidemiological studies have indicated that strongly contributes to development cancer, cardiovascular diseases, type 2 diabetes, liver diseases and other disorders, accounting for a heavy burden on public health-care systems every year. Excess energy uptake induces adipocyte hypertrophy, hyperplasia formation visceral fat in non-adipose tissues evoke disease, diseases. Adipose tissue can also secrete adipokines inflammatory cytokines affect local microenvironment, induce insulin resistance, hyperglycemia, activate associated signaling pathways. This further exacerbates progression obesity-associated Although some progress treatment been achieved preclinical clinical studies, pathogenesis obesity-induced are complex unclear. We still need understand their links better guide In this review, we review between with view improve future management its co-morbidities.
Язык: Английский
Процитировано
175
Biomedicine & Pharmacotherapy, Год журнала: 2023, Номер 168, С. 115734 - 115734
Опубликована: Окт. 17, 2023
Nowadays, diabetes mellitus has emerged as a significant global public health concern with remarkable increase in its prevalence. This review article focuses on the definition of and classification into different types, including type 1 (idiopathic fulminant), 2 diabetes, gestational hybrid forms, slowly evolving immune-mediated ketosis-prone other special types. Diagnostic criteria for are also discussed. The role inflammation both is explored, along mediators potential anti-inflammatory treatments. Furthermore, involvement various organs highlighted, such adipose tissue obesity, gut microbiota, pancreatic β-cells. manifestation Langerhans β-cell islet inflammation, oxidative stress, impaired insulin production secretion addressed. Additionally, impact liver cirrhosis, acute kidney injury, immune system complications, diabetic complications like retinopathy neuropathy examined. Therefore, further research required to enhance diagnosis, prevent chronic identify therapeutic targets management associated dysfunctions.
Язык: Английский
Процитировано
140
Bone Research, Год журнала: 2023, Номер 11(1)
Опубликована: Дек. 6, 2023
Abstract Although aging has traditionally been viewed as the most important risk factor for osteoarthritis (OA), an increasing amount of epidemiological evidence highlighted association between metabolic abnormalities and OA, particularly in younger individuals. Metabolic abnormalities, such obesity type II diabetes, are strongly linked to they affect both weight-bearing non-weight-bearing joints, thus suggesting that pathogenesis OA is more complicated than mechanical stress induced by overweight. This review aims explore recent advances research on relationship risk, including impact abnormal glucose lipid metabolism, potential targeted therapeutic strategies.
Язык: Английский
Процитировано
57
Diabetology & Metabolic Syndrome, Год журнала: 2023, Номер 15(1)
Опубликована: Март 15, 2023
Abstract Sarcopenia is a multifactorial disease characterized by reduced muscle mass and function, leading to disability, death, other diseases. Recently, the prevalence of sarcopenia increased considerably, posing serious threat health worldwide. However, no clear international consensus has been reached regarding etiology sarcopenia. Several studies have shown that insulin resistance may be an important mechanism in pathogenesis induced attenuation that, conversely, can lead resistance. causal relationship between two not clear. In this paper, analyzed, possible intrinsic examined, research progress expounded provide basis for clinical diagnosis, treatment, study
Язык: Английский
Процитировано
52
Immunity & Ageing, Год журнала: 2024, Номер 21(1)
Опубликована: Фев. 5, 2024
Abstract Obesity, which is the accumulation of fat in adipose tissue, has adverse impacts on human health. Obesity-related metabolic dysregulation similarities to alterations observed aging. It been shown that adipocytes obese individuals undergo cellular aging, known as senescence. Senescence can be transmitted other normal cells through a series chemical factors referred senescence-associated secretory phenotype (SASP). Most these are pro-inflammatory compounds. The immune system removes senescent T-cells, but immunosenescence, senescence cells, disrupts clearance T-cells. Immunosenescence occurs result aging or indirectly transmission from tissues. significant occurrence obesity expected cause immunosenescence and impairs response resolve inflammation. sustained chronic inflammation insulin's actions Therefore, this review focuses role adipocyte obesity-associated subsequent dysregulation. Moreover, article suggests novel therapeutic approaches improve syndrome by targeting T-cells using senotherapeutics. Graphical
Язык: Английский
Процитировано
22
Cardiovascular Diabetology, Год журнала: 2024, Номер 23(1)
Опубликована: Янв. 13, 2024
Abstract Background Studies have shown that insulin resistance is strongly associated with the development of cardiovascular disease, and triglyceride glucose-body mass index (TyG-BMI index) considered to be a reliable surrogate marker resistance. There are limited studies on relationship between TyG-BMI extent coronary artery disease in patients acute syndrome (ACS). This study aimed investigate ACS. Methods Overall, 2,317 ACS who underwent percutaneous intervention at Affiliated Hospital Zunyi Medical University were included this study. The was grouped according tertile method. quantitatively assessed using SYNTAX score, which categorised as low (≤ 22), intermediate (23–32), high risk (≥ 33). Results In overall population, multivariate logistic regression analyses showed mid/high score (odds ratio [OR] = 1.0041; 95% confidence interval [CI] 1.0000–1.0079; p 0.0310). Subgroup an independent factor for female after adjusting multiple confounders (OR 1.0100; CI 1.0000–1.0200; 0.0050), 2.49 times higher T3 group 2.4900; 1.2200–5.0600; 0.0120). Restricted cubic spline analysis linear correlation complex (SYNTAX > 22) women patients, inclusion did not improve predictive power underlying model (net reclassification improvement: 0.0867 [-0.0256–0.1989], 0.1301; integrated discrimination 0.0183 [0.0038–0.0329], 0.0135). Conclusions linearly degree patients. However,
Язык: Английский
Процитировано
20
Scientific Reports, Год журнала: 2024, Номер 14(1)
Опубликована: Май 13, 2024
Abstract To investigate the screening and predicting functions of obesity- lipid-related indices for type 2 diabetes (T2D) in middle-aged elderly Chinese, as well ideal predicted cut-off value. This study's data comes from 2011 China Health Retirement Longitudinal Study (CHARLS). A cross-sectional study design was used to relationship T2D 13 indices, including body mass index (BMI), waist circumference (WC), waist–height ratio (WHtR), visceral adiposity (VAI), a shape (ABSI), roundness (BRI), lipid accumulation product (LAP), conicity (CI), Chinese (CVAI), triglyceride- glucose (TyG index) its correlation (TyG-BMI, TyG-WC, TyG-WHtR). The unadjusted adjusted correlations between were assessed using binary logistic regression analysis. receiver operating characteristic curve (ROC) determine usefulness anthropometric determining their cut‑off value, sensitivity, specificity, area under (AUC). comprised 9488 people aged 45 years or above total, whom 4354 (45.89%) males 5134 (54.11%) females. Among them 716 male cases (16.44%) 870 female (16.95%). total independently associated with risk after confounding factors ( P < 0.05). According ROC analysis, TyG best predictor among (AUC = 0.780, 95% CI 0.761, 0.799) females 0.782, 0.764, 0.799). AUC values indicators higher than 0.5, indicating that they have predictive Chinese. can predict middle‑aged indicators, is both TyG-BMI, TyG-WHtR, LAP, CVAI all outperformed BMI, WC, WHtR T2D.
Язык: Английский
Процитировано
18
Cardiovascular Diabetology, Год журнала: 2024, Номер 23(1)
Опубликована: Янв. 3, 2024
Abstract Background Obesity has increased in recent years with consequences on diabetes and other comorbidities. Thus, 1 out of 3 diabetic patients suffers cardiovascular disease (CVD). The network among glucose, immune system, endothelium epicardial fat an important role pro-inflammatory thrombotic mechanisms atherogenesis. Since semaglutide, long-acting glucagon like peptide 1- receptor agonist (GLP-1-RA), a glucose-lowering drug, reduces body weight, we aimed to study its effects human (EAT), aortic endothelial cells neutrophils as atherogenesis involved-cardiovascular cells. Methods EAT subcutaneous (SAT) were collected from undergoing cardiac surgery. Differential glucose consumption protein cargo fat-released exosomes, after semaglutide or/and insulin treatment analyzed by enzymatic TripleTOF, respectively. Human phenotype their adhesion (HAEC) or angiogenesis flow cytometry functional fluorescence analysis. Immune plasma markers determined Luminex-multiplex before 6 months semaglutide. Results GLP-1 was expressed neutrophils. exosomes-protein identified explants treatment. This drug secretion gelsolin, antithrombotic protein, EAT, modulated CD11b neutrophils, migration adhesion, induced adiposity FABP4, chemoattractant. Monocytes adiposity, stretch, mesothelial, fibrotic, inflammatory underwent for showed 20% reduction statistical significance FABP4 levels 80% increase neutrophils-CD88. Conclusion Semaglutide increases endocrine activity properties. Moreover, this modulates the atherogenic profile marker, which is also reduced
Язык: Английский
Процитировано
17