Exploring the links between polyphenols, Nrf2, and diabetes: A review

Biomedicine & Pharmacotherapy, Год журнала: 2025, Номер 186, С. 118020 - 118020

Опубликована: Апрель 2, 2025

Язык: Английский

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Mechanisms of cinnamic aldehyde against myocardial ischemia/hypoxia injury in vivo and in vitro: Involvement of regulating PI3K/AKT signaling pathway

Biomedicine & Pharmacotherapy, Год журнала: 2022, Номер 147, С. 112674 - 112674

Опубликована: Янв. 29, 2022

To investigate the protection of cinnamic aldehyde (CA) against myocardial ischemia/hypoxia (I/H) injury and its potential mechanisms in vivo vitro. Mice were pretreated with CA for 7 days, then isoproterenol (85 mg/kg) was administered 2 consecutive days to assess cardioprotection. Furthermore, an vitro I/H model established by administering CoCl2 (600 μM) H9c2 cells 24 h. 12 h protection. We observed that improved electrocardiogram histopathological changes decreased creatine kinase lactate dehydrogenase activities oxidative stress levels. The TUNEL results showed reduced degree apoptosis. could lead a down-regulation Caspase-3 Bax protein expressions, but up-regulation Bcl-2 expressions. Importantly, increased p-PI3K p-AKT indicating activation PI3K/AKT signaling pathway. Moreover, treatment cell viability rate mitochondrial membrane while markedly decreasing apoptosis levels Our suggested exerts cardioprotection on injury, which possibly occurred connection inhibition via

Язык: Английский

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Liquiritin Protects Against Cardiac Fibrosis After Myocardial Infarction by Inhibiting CCL5 Expression and the NF-κB Signaling Pathway

Drug Design Development and Therapy, Год журнала: 2022, Номер Volume 16, С. 4111 - 4125

Опубликована: Дек. 1, 2022

Purpose: Despite significant advances in interventional treatment, myocardial infarction (MI) and subsequent cardiac fibrosis remain major causes of high mortality worldwide. Liquiritin (LQ) is a flavonoid extract from licorice that possesses variety pharmacological properties. However, to our knowledge, the effects LQ on after MI have not been reported detail. The aim research was explore potential role mechanism MI-induced damage. Methods: models were established by ligating left anterior descending branch coronary artery. Next, rats orally administered once day for 14 days. Biochemical assays, histopathological observations, ELISA, Western blotting analyses then conducted. Results: improved heart appearance ECG, decreased weight index reduced levels cardiac-specific markers such as CK, CK-MB, LDH, cTnI BNP. Meanwhile, infarct size hemodynamic parameters LVEDP, LVSP ±dp/dt max . Moreover, H&E staining showed attenuated pathological damage caused MI. Masson alleviated cell disorder while reducing collagen deposition. also oxidative stress inflammation. demonstrated significantly down-regulated expressions Collagen I, III, TGF-β 1, MMP-9, α-SMA, CCL5, p-NF-κB. Conclusion: protected against following improving function, attenuating inflammatory response, which may be associated with inhibition CCL5 expression NF-κB pathway. Keywords: liquiritin, fibrosis, infarction, expression, signaling pathway A Letter Editor has published this article

Язык: Английский

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Aconitum carmichaelii Debx. Attenuates Heart Failure through Inhibiting Inflammation and Abnormal Vascular Remodeling

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(6), С. 5838 - 5838

Опубликована: Март 19, 2023

Heart failure (HF) is the most common complication following myocardial infarction, closely associated with ventricular remodeling. Aconitum carmichaelii Debx., a traditional Chinese herb, possesses therapeutic effects on HF and related cardiac diseases. However, its mechanisms HF-associated diseases are still unclear. In present study, water extraction of toasted Debx. (WETA) was verified using UPLC-Q/TOF-MS. The heart function rats assessed by echocardiography strain analysis, injury measured serum levels CK-MB, cTnT, cTnI. pathological changes tissues were evaluated 2,3,5-triphenyltetrazolium chloride (TTC) staining, hematoxylin eosin (H&E) Masson's trichrome staining. Additionally, inflammation-related genes proteins components to vascular remodeling detected RT-qPCR, Western blot, immunofluorescence. WETA significantly inhibited in echocardiographic parameters increase weight, infarction size, myonecrosis, edema, infiltration inflammatory cells, collagen deposition tissues, also mitigated elevated cTnI ISO-induced rats. suppressed expressions genes, including IL-1β, IL-6, TNF-α injury-related such as VCAM1, ICAM1, ANP, BNP, MHC rats, which further confirmed blotting summary, protective effect conferred through inhibiting responses abnormal ISO-treated

Язык: Английский

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Betulinic acid attenuates T-2 toxin-induced lung injury by activating Nrf2 signaling pathway and inhibiting MAPK/NF-κB signaling pathway

Toxicon, Год журнала: 2024, Номер unknown, С. 107652 - 107652

Опубликована: Фев. 1, 2024

Язык: Английский

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