Frontiers in Pharmacology,
Год журнала:
2023,
Номер
14
Опубликована: Март 28, 2023
Cardiac
fibrosis
plays
an
indispensable
role
in
cardiac
tissue
homeostasis
and
repair
after
myocardial
infarction
(MI).
The
fibroblast-to-myofibroblast
differentiation
extracellular
matrix
collagen
deposition
are
the
hallmarks
of
fibrosis,
which
modulated
by
multiple
signaling
pathways
various
types
cells
time-dependent
manners.
Our
understanding
development
MI
has
evolved
basic
clinical
researches,
regulation
fibrotic
remodeling
may
facilitate
novel
diagnostic
therapeutic
strategies,
finally
improve
outcomes.
Here,
we
aim
to
elaborate
pathophysiology,
examination
intervention
MI.
Phytotherapy Research,
Год журнала:
2023,
Номер
38(1), С. 174 - 186
Опубликована: Окт. 17, 2023
Abstract
Psoriasis
is
a
common
immune‐mediated
inflammatory
skin
disease,
caused
by
disturbed
interactions
between
keratinocytes
and
immune
cells.
Chinese
medicine
shows
potential
clinical
application
for
its
treatment.
Liquiritin
flavone
compound
extracted
from
licorice
antitussive,
antioxidant
antiinflammatory
effects,
therefore
may
have
as
psoriasis
therapeutic.
The
aim
of
this
work
was
to
examine
the
possible
roles
that
liquiritin
in
treating
psoriasis.
HaCaT
cells
were
stimulated
TNF‐α
with
or
without
liquiritin,
harvested
analysis
western
blots
RT‐qPCR,
cellular
supernatants
collected
analyzed
ELISA
cytokines.
In
addition,
4
groups
mice
examined:
Normal,
Vehicle,
LQ‐L
LQ‐H.
sacrificed
after
6
days
using
IHC,
ELISA,
RT‐qPCR
flow
cytometry.
results
showed
could
significantly
inhibit
progression
both
vitro
vivo.
strongly
suppressed
proliferation
but
did
not
affect
cell
viability.
Moreover,
alleviated
imiquimod‐induced
psoriasis‐like
inflammation
accumulation
Th17
DCs
TNF‐α‐induced
keratinocytes,
protein
mRNA
expression
levels
cytokines
sharply
decreased.
mice,
activation
NF‐κB
AP‐1
reduced
treatment
liquiritin.
Collectively,
our
show
might
act
pivotal
regulator
via
modulating
signal
pathways.
Frontiers in Pharmacology,
Год журнала:
2024,
Номер
15
Опубликована: Сен. 4, 2024
Despite
advancements
in
diabetes
treatment,
the
management
of
Painful
Diabetic
Neuropathy
(PDN)
remains
challenging.
Our
previous
research
indicated
a
significant
correlation
between
expression
and
distribution
Aquaporin-4
(AQP4)
spinal
glymphatic
system
PDN.
However,
potential
role
mechanism
liquiritin
PDN
treatment
remain
uncertain.
Medicine,
Год журнала:
2023,
Номер
102(46), С. e35919 - e35919
Опубликована: Ноя. 17, 2023
Ischemic
strokes
(ISs)
are
commonly
treated
by
intravenous
thrombolysis
using
a
recombinant
tissue
plasminogen
activator;
however,
successful
treatment
can
only
occur
within
3
hours
after
the
stroke.
Therefore,
it
is
crucial
to
determine
causes
and
underlying
molecular
mechanisms,
identify
biomarkers
for
early
diagnosis,
develop
precise
preventive
treatments
strokes.
We
aimed
clarify
differences
in
gene
expression,
drug
prediction
approaches
between
IS
myocardial
infarction
(MI)
comprehensive
bioinformatics
analysis.
The
pathogenesis
of
these
diseases
was
explored
provide
directions
future
clinical
research.
(GSE58294
GSE16561)
MI
(GSE60993
GSE141512)
datasets
were
downloaded
from
Gene
Expression
Omnibus
database.
transcriptome
data
analyzed
methods,
differentially
expressed
genes
(DEGs)
screened.
A
protein-protein
interaction
network
constructed
STRING
database
visualized
Cytoscape,
candidate
with
high
confidence
scores
identified
Degree,
MCC,
EPC,
DMNC
cytoHubba
plug-in.
Ontology
(GO)
Kyoto
Encyclopedia
Genes
Genomes
(KEGG)
pathway
enrichment
analyses
DEGs
performed
annotation,
visualization,
integrated
discovery
Network
Analyst
3.0
used
construct
transcription
factor
(TF)
-
microRNA
(miRNA)
regulatory
networks
genes.
DrugBank
5.0
gene-drug
interactions.
After
analysis
microarray
data,
115
44
DEGS
obtained
MI,
respectively.
Moreover,
8
hub
genes,
2
miRNAs,
TFs
13
pathology
presented
terms
GO
KEGG
pathways,
TFs,
drugs.
These
findings
possible
diagnosis
future.
