Nutrition and Cancer,
Год журнала:
2024,
Номер
76(10), С. 974 - 984
Опубликована: Июль 21, 2024
This
study
aimed
to
explore
the
association
between
dietary
intake
of
tomatoes
and
lycopene
with
all-cause
cancer
mortality
among
US
adults
diabetes.
We
hypothesized
that
a
higher
tomato
is
related
reduced
risk
prospective
was
conducted
9213
diabetes
using
data
from
National
Health
Nutrition
Examination
Survey
(NHANES)
2007-2016.
Data
on
were
obtained
two
24-h
recalls.
Multivariate
Cox
proportional
hazard
models
determined
associations
tomato/lycopene
mortality.
A
significantly
associated
lower
(tomato:
Q5
vs.
Q1:
HR
=
0.68,
95%
CI
0.54-0.86,
Molecules,
Год журнала:
2022,
Номер
27(23), С. 8503 - 8503
Опубликована: Дек. 3, 2022
Since
lycopene
has
antioxidant
activity,
its
combination
with
metformin
may
be
useful
to
contrast
diabetic
complications
related
oxidative
stress.
This
study
aimed
investigate
the
effects
of
combined
on
high-fat
diet
(HFD)-induced
obese
mice.
Seventy-two
C57BL-6J
mice
were
divided
into
six
groups:
C
(control
diet-fed
mice),
H
(HFD-fed
for
17
weeks),
H-V
treated
vehicle),
H-M
50
mg/kg
metformin),
H-L
45
lycopene),
and
H-ML
+
lycopene).
Treatments
administered
8
weeks.
Glucose
tolerance,
insulin
sensitivity,
fluorescent
AGEs
(advanced
glycation
end
products),
TBARS
(thiobarbituric
acid-reactive
substances),
activities
enzymes
paraoxonase-1
(PON-1;
plasma),
superoxide
dismutase,
catalase
glutathione
peroxidase
(liver
kidneys)
determined.
Metformin
plus
reduced
body
weight;
improved
sensitivity
glucose
tolerance;
decreased
in
plasma,
liver
kidneys.
Combined
therapy
significantly
increased
enzymes,
mainly
PON-1.
Lycopene
resistance
caused
further
increases
endogenous
defenses,
arising
as
a
promising
therapeutic
strategy
combating
resulting
from
glycoxidative
Pharmaceuticals,
Год журнала:
2022,
Номер
15(11), С. 1420 - 1420
Опубликована: Ноя. 17, 2022
The
complicated
disorder
of
hypercholesterolemia
has
several
underlying
factors,
including
genetic
and
lifestyle
factors.
Low
LDL
cholesterol
elevated
serum
total
are
its
defining
features.
A
carotenoid
with
antioxidant
quality
is
lycopene.
Examining
lycopene
activity
in
an
animal
model
induced
using
food
was
the
aim
this
investigation.
Triglycerides,
cholesterol,
HDL
plasma
were
all
measured.
Biomarkers
renal
cardiac
function
also
examined.
Apoptotic
indicators,
pro-inflammatory
markers,
oxidative
stress
assessed.
Additionally,
mRNA
expression
paraoxonase
1
(PON-1),
peroxisome
proliferator-activated
receptor
gamma
(PPAR-γ),
PPAR-γ
coactivator
alpha
(PGC-1α)
tissues
Rats
showed
lipid
levels,
dysfunction,
significant
stress,
apoptotic
markers
at
end
study.
Treatment
significantly
corrected
restored
these
changes.
markedly
increased
PGC-1α
PON-1,
decreased
expression.
It
determined
that
capacity
to
modulate
PON-1
signaling
pathway
order
preserve
cellular
energy
metabolism
heart
kidney,
which
turn
reduces
tissue
inflammatory
response
apoptosis.
According
findings,
may
be
utilized
as
a
medication
treat
hypercholesterolemia.
However,
further
studies
should
conducted
first
determine
appropriate
dose
any
adverse
effects
appear
after
usage
humans.
Molecules,
Год журнала:
2023,
Номер
28(20), С. 7069 - 7069
Опубликована: Окт. 13, 2023
,
belonging
to
the
family
Apocynaceae,
is
one
of
best-known
medicinal
plants
in
Africa
and
Asia.
Stem
back
preparations
are
traditionally
used
as
muscle
relaxants.
This
study
investigated
antispasmodic
properties
Nutrition and Cancer,
Год журнала:
2024,
Номер
76(10), С. 974 - 984
Опубликована: Июль 21, 2024
This
study
aimed
to
explore
the
association
between
dietary
intake
of
tomatoes
and
lycopene
with
all-cause
cancer
mortality
among
US
adults
diabetes.
We
hypothesized
that
a
higher
tomato
is
related
reduced
risk
prospective
was
conducted
9213
diabetes
using
data
from
National
Health
Nutrition
Examination
Survey
(NHANES)
2007-2016.
Data
on
were
obtained
two
24-h
recalls.
Multivariate
Cox
proportional
hazard
models
determined
associations
tomato/lycopene
mortality.
A
significantly
associated
lower
(tomato:
Q5
vs.
Q1:
HR
=
0.68,
95%
CI
0.54-0.86,
