Associations Between Dietary Intake of Tomato and Lycopene with All-Cause and Cancer-Specific Mortality in US Adults with Diabetes: Results From a Cohort Study DOI
Yuqian Liu,

Heyin Liu,

Jinde Liu

и другие.

Nutrition and Cancer, Год журнала: 2024, Номер 76(10), С. 974 - 984

Опубликована: Июль 21, 2024

This study aimed to explore the association between dietary intake of tomatoes and lycopene with all-cause cancer mortality among US adults diabetes. We hypothesized that a higher tomato is related reduced risk prospective was conducted 9213 diabetes using data from National Health Nutrition Examination Survey (NHANES) 2007-2016. Data on were obtained two 24-h recalls. Multivariate Cox proportional hazard models determined associations tomato/lycopene mortality. A significantly associated lower (tomato: Q5 vs. Q1: HR = 0.68, 95% CI 0.54-0.86,

Язык: Английский

Combined Effects of Lycopene and Metformin on Decreasing Oxidative Stress by Triggering Endogenous Antioxidant Defenses in Diet-Induced Obese Mice DOI Creative Commons

Bruno Pereira Motta,

Camila Graça Pinheiro,

Ingrid Delbone Figueiredo

и другие.

Molecules, Год журнала: 2022, Номер 27(23), С. 8503 - 8503

Опубликована: Дек. 3, 2022

Since lycopene has antioxidant activity, its combination with metformin may be useful to contrast diabetic complications related oxidative stress. This study aimed investigate the effects of combined on high-fat diet (HFD)-induced obese mice. Seventy-two C57BL-6J mice were divided into six groups: C (control diet-fed mice), H (HFD-fed for 17 weeks), H-V treated vehicle), H-M 50 mg/kg metformin), H-L 45 lycopene), and H-ML + lycopene). Treatments administered 8 weeks. Glucose tolerance, insulin sensitivity, fluorescent AGEs (advanced glycation end products), TBARS (thiobarbituric acid-reactive substances), activities enzymes paraoxonase-1 (PON-1; plasma), superoxide dismutase, catalase glutathione peroxidase (liver kidneys) determined. Metformin plus reduced body weight; improved sensitivity glucose tolerance; decreased in plasma, liver kidneys. Combined therapy significantly increased enzymes, mainly PON-1. Lycopene resistance caused further increases endogenous defenses, arising as a promising therapeutic strategy combating resulting from glycoxidative

Язык: Английский

Процитировано

12

Lycopene Modulates Oxidative Stress and Inflammation in Hypercholesterolemic Rats DOI Creative Commons
Tarfa Albrahim

Pharmaceuticals, Год журнала: 2022, Номер 15(11), С. 1420 - 1420

Опубликована: Ноя. 17, 2022

The complicated disorder of hypercholesterolemia has several underlying factors, including genetic and lifestyle factors. Low LDL cholesterol elevated serum total are its defining features. A carotenoid with antioxidant quality is lycopene. Examining lycopene activity in an animal model induced using food was the aim this investigation. Triglycerides, cholesterol, HDL plasma were all measured. Biomarkers renal cardiac function also examined. Apoptotic indicators, pro-inflammatory markers, oxidative stress assessed. Additionally, mRNA expression paraoxonase 1 (PON-1), peroxisome proliferator-activated receptor gamma (PPAR-γ), PPAR-γ coactivator alpha (PGC-1α) tissues Rats showed lipid levels, dysfunction, significant stress, apoptotic markers at end study. Treatment significantly corrected restored these changes. markedly increased PGC-1α PON-1, decreased expression. It determined that capacity to modulate PON-1 signaling pathway order preserve cellular energy metabolism heart kidney, which turn reduces tissue inflammatory response apoptosis. According findings, may be utilized as a medication treat hypercholesterolemia. However, further studies should conducted first determine appropriate dose any adverse effects appear after usage humans.

Язык: Английский

Процитировано

11

Antispasmodic Effect of Alstonia boonei De Wild. and Its Constituents: Ex Vivo and In Silico Approaches DOI Creative Commons

Opeyemi Josephine Akinmurele,

Mubo Adeola Sonibare, A.A. Elujoba

и другие.

Molecules, Год журнала: 2023, Номер 28(20), С. 7069 - 7069

Опубликована: Окт. 13, 2023

, belonging to the family Apocynaceae, is one of best-known medicinal plants in Africa and Asia. Stem back preparations are traditionally used as muscle relaxants. This study investigated antispasmodic properties

Язык: Английский

Процитировано

6

Comparing lycopene's impact on mortality in adults with or without obesity DOI
Xiaorong Han, Jinxing Liu, Yingzhen Gu

и другие.

Food & Function, Год журнала: 2024, Номер 15(7), С. 3340 - 3352

Опубликована: Янв. 1, 2024

Serum lycopene exhibits distinct associations with all-cause and cardiovascular mortality in populations or without obesity.

Язык: Английский

Процитировано

2

Associations Between Dietary Intake of Tomato and Lycopene with All-Cause and Cancer-Specific Mortality in US Adults with Diabetes: Results From a Cohort Study DOI
Yuqian Liu,

Heyin Liu,

Jinde Liu

и другие.

Nutrition and Cancer, Год журнала: 2024, Номер 76(10), С. 974 - 984

Опубликована: Июль 21, 2024

This study aimed to explore the association between dietary intake of tomatoes and lycopene with all-cause cancer mortality among US adults diabetes. We hypothesized that a higher tomato is related reduced risk prospective was conducted 9213 diabetes using data from National Health Nutrition Examination Survey (NHANES) 2007-2016. Data on were obtained two 24-h recalls. Multivariate Cox proportional hazard models determined associations tomato/lycopene mortality. A significantly associated lower (tomato: Q5 vs. Q1: HR = 0.68, 95% CI 0.54-0.86,

Язык: Английский

Процитировано

2