Pharmaceuticals,
Journal Year:
2022,
Volume and Issue:
15(11), P. 1420 - 1420
Published: Nov. 17, 2022
The
complicated
disorder
of
hypercholesterolemia
has
several
underlying
factors,
including
genetic
and
lifestyle
factors.
Low
LDL
cholesterol
elevated
serum
total
are
its
defining
features.
A
carotenoid
with
antioxidant
quality
is
lycopene.
Examining
lycopene
activity
in
an
animal
model
induced
using
food
was
the
aim
this
investigation.
Triglycerides,
cholesterol,
HDL
plasma
were
all
measured.
Biomarkers
renal
cardiac
function
also
examined.
Apoptotic
indicators,
pro-inflammatory
markers,
oxidative
stress
assessed.
Additionally,
mRNA
expression
paraoxonase
1
(PON-1),
peroxisome
proliferator-activated
receptor
gamma
(PPAR-γ),
PPAR-γ
coactivator
alpha
(PGC-1α)
tissues
Rats
showed
lipid
levels,
dysfunction,
significant
stress,
apoptotic
markers
at
end
study.
Treatment
significantly
corrected
restored
these
changes.
markedly
increased
PGC-1α
PON-1,
decreased
expression.
It
determined
that
capacity
to
modulate
PON-1
signaling
pathway
order
preserve
cellular
energy
metabolism
heart
kidney,
which
turn
reduces
tissue
inflammatory
response
apoptosis.
According
findings,
may
be
utilized
as
a
medication
treat
hypercholesterolemia.
However,
further
studies
should
conducted
first
determine
appropriate
dose
any
adverse
effects
appear
after
usage
humans.
Molecules,
Journal Year:
2022,
Volume and Issue:
27(23), P. 8503 - 8503
Published: Dec. 3, 2022
Since
lycopene
has
antioxidant
activity,
its
combination
with
metformin
may
be
useful
to
contrast
diabetic
complications
related
oxidative
stress.
This
study
aimed
investigate
the
effects
of
combined
on
high-fat
diet
(HFD)-induced
obese
mice.
Seventy-two
C57BL-6J
mice
were
divided
into
six
groups:
C
(control
diet-fed
mice),
H
(HFD-fed
for
17
weeks),
H-V
treated
vehicle),
H-M
50
mg/kg
metformin),
H-L
45
lycopene),
and
H-ML
+
lycopene).
Treatments
administered
8
weeks.
Glucose
tolerance,
insulin
sensitivity,
fluorescent
AGEs
(advanced
glycation
end
products),
TBARS
(thiobarbituric
acid-reactive
substances),
activities
enzymes
paraoxonase-1
(PON-1;
plasma),
superoxide
dismutase,
catalase
glutathione
peroxidase
(liver
kidneys)
determined.
Metformin
plus
reduced
body
weight;
improved
sensitivity
glucose
tolerance;
decreased
in
plasma,
liver
kidneys.
Combined
therapy
significantly
increased
enzymes,
mainly
PON-1.
Lycopene
resistance
caused
further
increases
endogenous
defenses,
arising
as
a
promising
therapeutic
strategy
combating
resulting
from
glycoxidative
Heliyon,
Journal Year:
2024,
Volume and Issue:
10(16), P. e35498 - e35498
Published: Aug. 1, 2024
The
increasing
scientific
interest
in
antioxidants
and
naturally
derived
compounds
as
potential
remedies
for
obesity
non-alcoholic
fatty
liver
disease
(NAFLD)
has
led
to
extensive
research.
objective
of
this
bibliometric
analysis
is
present
an
updated
perspective
on
the
topic
antioxidants,
herbs,
phytochemicals,
natural
compounds,
control
NAFLD,
identify
new
areas
future
Publications
from
years
2012-2022
were
retrieved
using
Scopus
database.
research
trends
analyzed
Biblioshiny
VOSviewer
tools.
field
seen
a
significant
increase
activity,
indicated
by
annual
growth
rate
10
%
number
published
manuscripts.
China,
Korea,
USA
emerged
most
prominent
contributors
specific
field,
supported
their
notable
volumes
publications
citations.
density
revealed
that
frequently
occurring
authors'
keywords
related
herbal
species
are,
rank
order
Pharmaceuticals,
Journal Year:
2022,
Volume and Issue:
15(11), P. 1420 - 1420
Published: Nov. 17, 2022
The
complicated
disorder
of
hypercholesterolemia
has
several
underlying
factors,
including
genetic
and
lifestyle
factors.
Low
LDL
cholesterol
elevated
serum
total
are
its
defining
features.
A
carotenoid
with
antioxidant
quality
is
lycopene.
Examining
lycopene
activity
in
an
animal
model
induced
using
food
was
the
aim
this
investigation.
Triglycerides,
cholesterol,
HDL
plasma
were
all
measured.
Biomarkers
renal
cardiac
function
also
examined.
Apoptotic
indicators,
pro-inflammatory
markers,
oxidative
stress
assessed.
Additionally,
mRNA
expression
paraoxonase
1
(PON-1),
peroxisome
proliferator-activated
receptor
gamma
(PPAR-γ),
PPAR-γ
coactivator
alpha
(PGC-1α)
tissues
Rats
showed
lipid
levels,
dysfunction,
significant
stress,
apoptotic
markers
at
end
study.
Treatment
significantly
corrected
restored
these
changes.
markedly
increased
PGC-1α
PON-1,
decreased
expression.
It
determined
that
capacity
to
modulate
PON-1
signaling
pathway
order
preserve
cellular
energy
metabolism
heart
kidney,
which
turn
reduces
tissue
inflammatory
response
apoptosis.
According
findings,
may
be
utilized
as
a
medication
treat
hypercholesterolemia.
However,
further
studies
should
conducted
first
determine
appropriate
dose
any
adverse
effects
appear
after
usage
humans.
